A patient-derived amyotrophic lateral sclerosis blood-brain barrier model for focused ultrasound-mediated anti-TDP-43 antibody delivery

Autor: Joanna M. Wasielewska, Juliana C. S. Chaves, Mauricio Castro Cabral-da-Silva, Martina Pecoraro, Stephani J. Viljoen, Tam Hong Nguyen, Vincenzo La Bella, Lotta E. Oikari, Lezanne Ooi, Anthony R. White

Publikováno v: Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-20 (2024)

Abstract Background Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disorder with minimally effective treatment options. An important hurdle in ALS drug development is the non-invasive therapeutic access to the motor co

Externí odkaz: https://doaj.org/article/8207c90e135c40859406d7de78f6d21d

Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone–Pyridylhydrazone Copper(II) Complex

Autor: Xin Yi Choo, Lachlan E. McInnes, Alexandra Grubman, Joanna M. Wasielewska, Irina Belaya, Emma Burrows, Hazel Quek, Jorge Cañas Martín, Sanna Loppi, Annika Sorvari, Dzhessi Rait, Andrew Powell, Clare Duncan, Jeffrey R. Liddell, Heikki Tanila, Jose M. Polo, Tarja Malm, Katja M. Kanninen, Paul S. Donnelly, Anthony R. White

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 18, p 10722 (2022)

Neuroinflammation has a major role in several brain disorders including Alzheimer’s disease (AD), yet at present there are no effective anti-neuroinflammatory therapeutics available. Copper(II) complexes of bis(thiosemicarbazones) (CuII(gtsm) and C

Externí odkaz: https://doaj.org/article/3073c8cf0ef742229d8546a5099c39d0

Alzheimer’s disease brain endothelial-like cells reveal differential drug transporter expression and modulation by potentially therapeutic focused ultrasound

Autor: Juliana C.S. Chaves, Joanna M. Wasielewska, Carla Cuni-Lopez, Laura M. Rantanen, Serine Lee, Jari Koistinaho, Anthony R. White, Lotta E. Oikari

Background The blood-brain barrier (BBB) has a major role in maintaining homeostasis of the brain. The primary function of the BBB is regulating the entry of molecules from the blood to the brain while protecting the brain from potentially harmful en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8fae78b4cd8591bc5076980c4100450e
https://doi.org/10.21203/rs.3.rs-2605800/v1

A sporadic Alzheimer's blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies

Autor: Joanna M. Wasielewska, Juliana C. S. Chaves, Rebecca L. Johnston, Laura A. Milton, Damián Hernández, Liyu Chen, Jae Song, Wendy Lee, Gerhard Leinenga, Rebecca M. Nisbet, Alice Pébay, Jürgen Götz, Anthony R. White, Lotta E. Oikari

Publikováno v: Theranostics. 12:6826-6847

RationaleThe blood-brain barrier (BBB) is a major impediment to therapeutic intracranial drug delivery for the treatment of neurodegenerative diseases, including Alzheimer’s disease (AD). Focused ultrasound applied together with microbubbles (FUS+M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee37936f52da7b15d2a42c8f061558b
https://doi.org/10.7150/thno.72685

Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life

Autor: Gonzalo Arias-Gil, Gerd Kempermann, Benedetta Artegiani, Joanna M. Wasielewska, Gabriel Berdugo-Vega, Chi-Chieh Lee, Federico Calegari, Kentaroh Takagaki, Michael T. Lippert, Adrian López-Fernández

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications, 11(1):135
Nature Communications 11(1), 135 (2020). doi:10.1038/s41467-019-14026-z

Functional plasticity of the brain decreases during ageing causing marked deficits in contextual learning, allocentric navigation and episodic memory. Adult neurogenesis is a prime example of hippocampal plasticity promoting the contextualisation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f8c45704bcf362ba69e3a7a7ea41de
https://doaj.org/article/053faa42850e4fdca82723e9f3346693