Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Joanna M. Redmond"'
Autor:
Jack Ayre, Joanna M. Redmond, Giovanni Vitulli, Laura Tomlinson, Richard Weaver, Eleonora Comeo, Cynthia Bosquillon, Michael J. Stocks
Publikováno v:
Journal of Medicinal Chemistry. 65:9802-9818
A major limitation of pulmonary delivery is that drugs can exhibit suboptimal pharmacokinetic profiles resulting from rapid elimination from the pulmonary tissue. This can lead to systemic side effects and a short duration of action. A series of diba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16df6142b80ae58957462c52aa4df53c
https://doi.org/10.1021/acs.jmedchem.2c00416
https://doi.org/10.1021/acs.jmedchem.2c00416
Autor:
Simon Peace, Gianpaolo Bravi, Máire A. Convery, Hannah Davies, Graham G. A. Inglis, Joanna M. Redmond, Sandeep Pal, Heather Hobbs, Declan Summers, Ian B. Campbell
Publikováno v:
Journal of Medicinal Chemistry. 62:6972-6984
4-(Pyrimidin-4-yl)morpholines are privileged pharmacophores for PI3K and PIKKs inhibition by virtue of the morpholine oxygen, both forming the key hydrogen bonding interaction and conveying selectivity over the broader kinome. Key to the morpholine u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2748d65fb9fe5910b1e6ccf3827644ab
https://doi.org/10.1021/acs.jmedchem.9b00348
https://doi.org/10.1021/acs.jmedchem.9b00348
Autor:
Ainara Lopez Pardo, Silvia Martini, Joanna M. Redmond, Jacqueline J. T. Marshall, Peter J. Parker, Marco Vitale, Khalil Davis, Tanya N. Soliman, Joanna R. Kelly, Nicola Lockwood
Publikováno v:
Advances in Biological Regulation
Associated with their roles as targets for tumour promoters, there has been a long-standing interest in how members of the protein kinase C (PKC) family act to modulate cell growth and division. This has generated a great deal of observational data,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3b5501aa04a4f101f35c44d79a134d
https://doi.org/10.1016/j.jbior.2020.100759
https://doi.org/10.1016/j.jbior.2020.100759
Autor:
Diane M. Coe, Andrei Mihut, Michelle Anne Bartholomew, Joanna M. Redmond, John P. Evans, Rishi R. Shah, John A. Murphy, Malini Menon
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115326
PROTACs have recently emerged as a novel paradigm in drug discovery. They can hijack existing biological machinery to selectively degrade proteins of interest, in a catalytic fashion. Here we describe the design, optimisation and biological activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ddbf5bcb860bd75799cc32b7f74012
https://doi.org/10.1016/j.bmc.2020.115326
https://doi.org/10.1016/j.bmc.2020.115326
Autor:
Alan R. Kennedy, Joanna M. Redmond, Peter G. Wilson, David Orr, Jonathan M. Percy, James W. B. Fyfe, Sergej Maciuk, Helena S. Emerson, Lucie Rathouská
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 22(34)
Palladium-catalysed coupling reactions based on a novel and easy-to-synthesise difluorinated organotrifluoroborate were used to assemble precursors to 6π-electrocyclisations of three different types. Electrocyclisations took place at temperatures be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed64a7f3f16902a072884707a4f59cef
https://pubmed.ncbi.nlm.nih.gov/27415819
https://pubmed.ncbi.nlm.nih.gov/27415819
Publikováno v:
The Journal of Organic Chemistry. 77:6384-6393
A recently developed method for the near-ambient generation of difluorovinylzinc reagents has facilitated the preparation of 1-(N,N-diethylcarbamoyloxy)-2,2-difluoro-1-iodoethene and 2,2-difluoro-1-iodo-1-(2'-methoxyethoxymethoxy)ethene. The utility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c190d078afbd958cbfbc51efe0ffa7ef
https://doi.org/10.1021/jo3011705
https://doi.org/10.1021/jo3011705
Autor:
Joanna M. Redmond, Rebecca H. Pouwer, Thais Cailleau, Andrew J. P. White, Gemma Cansell, Stephen A. Hermitage, D. Christopher Braddock
Publikováno v:
Tetrahedron: Asymmetry. 21:2911-2919
The condensation of enantiopure 1,2-diamines with terephthalaldehyde, isophthalaldehyde or 2-iodo-, 2-alkyl- or 2-aryl-1,3-benzenedialdehydes in toluene followed by treatment with NBS in dichloromethane gives direct access to enantiopure 1,4-, and 1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad61afd462e02dff0c7df16956758a7f
https://doi.org/10.1016/j.tetasy.2010.12.002
https://doi.org/10.1016/j.tetasy.2010.12.002
Autor:
Ciaran P. Seath, Joanna M. Redmond, James W. B. Fyfe, Anderson Niall Andrew, Elena Valverde, Allan J. B. Watson, Alan R. Kennedy
Publikováno v:
ChemInform. 46
Boronic acid solution speciation can be controlled during the Suzuki-Miyaura cross-coupling of haloaryl N-methyliminodiacetic acid (MIDA) boronic esters to enable the formal homologation of boronic acid derivatives. The reaction is contingent upon co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31bc6b636d40bcb9f25d2b680121013e
https://doi.org/10.1002/chin.201543192
https://doi.org/10.1002/chin.201543192
Autor:
Alan R. Kennedy, Ciaran P. Seath, Elena Valverde, Joanna M. Redmond, Allan J. B. Watson, James W. B. Fyfe, Anderson Niall Andrew
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 21(24)
Boronic acid solution speciation can be controlled during the Suzuki-Miyaura cross-coupling of haloaryl N-methyliminodiacetic acid (MIDA) boronic esters to enable the formal homologation of boronic acid derivatives. The reaction is contingent upon co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c359a8dd175612c6462a9cf6df0a16
https://pubmed.ncbi.nlm.nih.gov/25959852
https://pubmed.ncbi.nlm.nih.gov/25959852
Publikováno v:
Advanced Synthesis & Catalysis. 348:911-916
A gram-scale preparation of (1S,2S)- and (1R,2R)-1,2-diamino-1,2-diphenylethanes, (1S,2S)-1 and (1R,2R)-1, is reported via (±)-iso-amarine 4. Strategically, the activation of (±)-iso-amarine 4 for hydrolysis to the required diamines and enantiomeri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8502eee8f289bf1f9c2a947aac637332
https://doi.org/10.1002/adsc.200505440
https://doi.org/10.1002/adsc.200505440