Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Joanna M. Kirkpatrick"'
Autor:
Nuria Tubío-Santamaría, Ashok Kumar Jayavelu, Tina M. Schnoeder, Theresa Eifert, Chen-Jen Hsu, Florian Perner, Qirui Zhang, Daniela V. Wenge, Fynn M. Hansen, Joanna M. Kirkpatrick, Nidhi Jyotsana, Steven W. Lane, Björn von Eyss, Aniruddha J. Deshpande, Michael W. M. Kühn, Juerg Schwaller, Clemens Cammann, Ulrike Seifert, Frédéric Ebstein, Elke Krüger, Andreas Hochhaus, Michael Heuser, Alessandro Ori, Matthias Mann, Scott A. Armstrong, Florian H. Heidel
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-21 (2023)
Abstract Pharmacologic targeting of chromatin-associated protein complexes has shown significant responses in KMT2A-rearranged (KMT2A-r) acute myeloid leukemia (AML) but resistance frequently develops to single agents. This points to a need for thera
Externí odkaz:
https://doaj.org/article/32a44bd3490c43d78d23fc64b13aaac5
Autor:
Dario Lucas Helbing, Joanna M. Kirkpatrick, Michael Reuter, Julia Bischoff, Amy Stockdale, Annemarie Carlstedt, Emilio Cirri, Reinhard Bauer, Helen Morrison
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Aging of the peripheral nervous system (PNS) is associated with structural and functional changes that lead to a reduction in regenerative capacity and the development of age-related peripheral neuropathy. Myelin is central to maintaining physiologic
Externí odkaz:
https://doaj.org/article/95ec0a759be34c7dbea740698ed0ee90
Autor:
Simone Di Sanzo, Katrin Spengler, Anja Leheis, Joanna M. Kirkpatrick, Theresa L. Rändler, Tim Baldensperger, Therese Dau, Christian Henning, Luca Parca, Christian Marx, Zhao-Qi Wang, Marcus A. Glomb, Alessandro Ori, Regine Heller
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Accumulation of advanced glycation end products such as carboxymethyllysine (CML) has been associated with aging but their molecular roles are largely unclear. Here, the authors use proteomics to identify CML sites and show that CML formation affects
Externí odkaz:
https://doaj.org/article/2a95d56d607f461daa73332371e24e27
Autor:
Nadja Gebert, Chia-Wei Cheng, Joanna M. Kirkpatrick, Domenico Di Fraia, Jina Yun, Patrick Schädel, Simona Pace, George B. Garside, Oliver Werz, K. Lenhard Rudolph, Henri Jasper, Ömer H. Yilmaz, Alessandro Ori
Publikováno v:
Cell Reports, Vol 31, Iss 4, Pp - (2020)
Summary: The small intestine is responsible for nutrient absorption and one of the most important interfaces between the environment and the body. During aging, changes of the epithelium lead to food malabsorption and reduced barrier function, thus i
Externí odkaz:
https://doaj.org/article/6ec250b7c1924a2c8eabf6e16788b454
Autor:
Ivonne Heinze, Martin Bens, Enrico Calzia, Susanne Holtze, Oleksandr Dakhovnik, Arne Sahm, Joanna M. Kirkpatrick, Karol Szafranski, Natalie Romanov, Sai Nagender Sama, Kerstin Holzer, Stephan Singer, Maria Ermolaeva, Matthias Platzer, Thomas Hildebrandt, Alessandro Ori
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-18 (2018)
Abstract Background Mammals display a wide range of variation in their lifespan. Investigating the molecular networks that distinguish long- from short-lived species has proven useful to identify determinants of longevity. Here, we compared the liver
Externí odkaz:
https://doaj.org/article/7d3091f112564f8b9a82f9ad024e5abe
Autor:
Aleksandar Bartolome, Julia C Heiby, Domenico Di Fraia, Ivonne Heinze, Hannah Knaudt, Ellen Spaeth, Omid Omrani, Alberto Minetti, Maleen Hofmann, Joanna M Kirkpatrick, Therese Dau, Alessandro Ori
Publikováno v:
eLife, Vol 13 (2024)
Proteasomes are essential molecular machines responsible for the degradation of proteins in eukaryotic cells. Altered proteasome activity has been linked to neurodegeneration, auto-immune disorders and cancer. Despite the relevance for human disease
Externí odkaz:
https://doaj.org/article/eb11939432d947b9a7853c59ac4621e3
Autor:
Harvey E. Johnston, Kranthikumar Yadav, Joanna M. Kirkpatrick, George S. Biggs, David Oxley, Holger B. Kramer, Rahul S. Samant
Publikováno v:
Analytical Chemistry. 94:10320-10328
Complete, reproducible extraction of protein material is essential for comprehensive and unbiased proteome analyses. A current gold standard is single-pot, solid-phase-enhanced sample preparation (SP3), in which organic solvent and magnetic beads are
Autor:
Rosa Cookson, Aini Vuorinen, Jonathan Pettinger, Cassandra R. Kennedy, Joanna M. Kirkpatrick, Rachel E. Peltier-Heap, Andrew Powell, Ambrosius P. Snijders, Mark Skehel, David House, Katrin Rittinger, Jacob T. Bush
SummaryChemoproteomics is a powerful method capable of detecting interactions between small molecules and the proteome, however its use as a high-throughput screening method for chemical libraries has so far been limited. To address this need, we hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ff8aafd003a34329baeafd8d02f1023
https://doi.org/10.1101/2023.02.01.526632
https://doi.org/10.1101/2023.02.01.526632
Autor:
Katharine E. Gilbert, Aini Vuorinen, Arron Aatkar, Peter Pogány, Jonathan Pettinger, Emma K. Grant, Joanna M. Kirkpatrick, Katrin Rittinger, David House, Glenn A. Burley, Jacob T. Bush
A comprehensive profiling of sulfur(VI) fluoride reactivity is reported in the context of fragment binders and optimized probes. The reactivity profile of an SVI-F panel is demonstrated using live cell chemoproteomics. The studies provide an in-depth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59458f436898af2b214b686cc11b1373
Autor:
Aleksandar Bartolome, Julia C. Heiby, Therese Dau, Domenico Di Fraia, Ivonne Heinze, Joanna M. Kirkpatrick, Alessandro Ori
SUMMARYProteasomes are essential molecular machines responsible for the degradation of proteins in eukaryotic cells. Altered proteasome activity has been linked to neurodegeneration, auto-immune disorders and cancer. Proteasomes have been exploited f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec49dcacbb2880545d5c4c77b8081232
https://doi.org/10.1101/2022.08.09.503299
https://doi.org/10.1101/2022.08.09.503299