Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Joanna M Long"'
Autor:
Golec Julian M C, Peter A. Charlton, Jean-Damien Charrier, Joanna M Long, Matthew R. Griffiths, Somhairle Maccormick, Philip Michael Reaper, John Pollard
Publikováno v:
Nature chemical biology. 7(7)
Here we report a comprehensive biological characterization of a potent and selective small-molecule inhibitor of the DNA damage response (DDR) kinase ATR. We show a profound synthetic lethal interaction between ATR and the ATM-p53 tumor suppressor pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd45edc683c9cc9064334f3aae74b6c
https://pubmed.ncbi.nlm.nih.gov/21490603
https://pubmed.ncbi.nlm.nih.gov/21490603
Publikováno v:
Journal of molecular biology. 354(5)
Transforming growth factor-beta (TGF-beta)-activated kinase 1 (TAK1) is a member of the MAPKKK family of protein kinases, and is involved in intracellular signalling pathways stimulated by transforming growth factor beta, interleukin-1 and tumour nec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d86af83d6a1b8070c0a90c7b781679
https://pubmed.ncbi.nlm.nih.gov/16289117
https://pubmed.ncbi.nlm.nih.gov/16289117
Autor:
J. Dan Frantz, Nicholas J. Dunster, Joanna M. Long, Mark A. Fleming, Graham Cheetham, Sarah Vial, Adam Tanner, Neesha Dedi, Kieron Brown, Suzanne Renwick
Publikováno v:
The Journal of biological chemistry. 279(18)
Interleukin-2 tyrosine kinase, Itk, is an important member of the Tec family of non-receptor tyrosine kinases that play a central role in signaling through antigen receptors such as the T-cell receptor, B-cell receptor, and Fcepsilon. Selective inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0afae6f065418a884c4fb948101fe41a
https://pubmed.ncbi.nlm.nih.gov/14766749
https://pubmed.ncbi.nlm.nih.gov/14766749