Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Joanna Lipka"'
Autor:
Sadhna Rao, Anastasiia Sadybekov, David C. DeWitt, Joanna Lipka, Vsevolod Katritch, Bruce E. Herring
Publikováno v:
Molecular Autism, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Background Glutamatergic synapse dysfunction is believed to underlie the development of Autism Spectrum Disorder (ASD) and Intellectual Disability (ID) in many individuals. However, identification of genetic markers that contribute to synapt
Externí odkaz:
https://doaj.org/article/e04f25582550489b9b9369030d6873fe
Autor:
Marta Esteves da Silva, Max Adrian, Philipp Schätzle, Joanna Lipka, Takuya Watanabe, Sukhee Cho, Kensuke Futai, Corette J. Wierenga, Lukas C. Kapitein, Casper C. Hoogenraad
Publikováno v:
Cell Reports, Vol 13, Iss 5, Pp 933-943 (2015)
Lateral diffusion in the membrane and endosomal trafficking both contribute to the addition and removal of AMPA receptors (AMPARs) at postsynaptic sites. However, the spatial coordination between these mechanisms has remained unclear, because little
Externí odkaz:
https://doaj.org/article/21093b42932a4bf1ba9c08b93abda438
Solving the Mysteries of Dementia: FTD Mutant Tau Impairs Structural Axon Initial Segment Plasticity
Autor:
Casper C. Hoogenraad, Joanna Lipka
Publikováno v:
Neuron, 104(3), 429. Cell Press
Neuron
Neuron
Dysregulation of neuronal excitability underlies the pathogenesis of tauopathies, including frontotemporal dementia (FTD) with tau inclusions. A majority of FTD-causing tau mutations are located in the microtubule-binding domain, but how these mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5a1eea62988b9935f40dfe385bae5e
https://dspace.library.uu.nl/handle/1874/389340
https://dspace.library.uu.nl/handle/1874/389340
Autor:
Amparo Acker-Palmer, Susanne Hoyer, Stefan Weinges, Joanna Lipka, Max A. Schlager, Inmaculada Segura, Phebe S. Wulf, Jeroen Demmers, Casper C. Hoogenraad, Julia C. Geiger
Publikováno v:
Developmental Cell, 28(4), 381. Cell Press
Developmental Cell, 28(4), 381-393. Cell Press
Dev Cell
Developmental Cell, 28(4), 381-393. Cell Press
Dev Cell
SummaryRegulation of cargo transport via adaptor molecules is essential for neuronal development. However, the role of PDZ scaffolding proteins as adaptors in neuronal cargo trafficking is still poorly understood. Here, we show by genetic deletion in
Autor:
Myrrhe van Spronsen, Phebe S. Wulf, Anna Akhmanova, Max A. Schlager, Marijn Kuijpers, Nanda Keijzer, Dave J. van den Heuvel, Lukas C. Kapitein, Hans C. Gerritsen, Joanna Lipka, Dick Jaarsma, Marina Mikhaylova, Jeroen Demmers, Casper C. Hoogenraad
Publikováno v:
Neuron, 77(3), 485. Cell Press
Neuron, 77(3), 485-502. Cell Press
Neuron, 77(3), 485-502. Cell Press
SummaryIn neurons, the distinct molecular composition of axons and dendrites is established through polarized targeting mechanisms, but it is currently unclear how nonpolarized cargoes, such as mitochondria, become uniformly distributed over these sp
Autor:
Esther de Graaff, Phebe S. Wulf, Martin Harterink, Lukas C. Kapitein, Cátia P. Frias, Josta T. Kevenaar, Nanda Keijzer, Marina Mikhaylova, Casper C. Hoogenraad, Sarah Bianchi, Natacha Olieric, Anna Ahkmanova, Myrrhe van Spronsen, Joanna Lipka, Michel O. Steinmetz, Manuel Hilbert
Publikováno v:
Current Biology
Current Biology, 26(7), 849. Cell Press
Current Biology, 26(7), 849-861. Cell Press
Current Biology, 26(7), 849. Cell Press
Current Biology, 26(7), 849-861. Cell Press
Kinesin motor proteins play a fundamental role for normal neuronal development by controlling intracellular cargo transport and microtubule (MT) cytoskeleton organization. Regulating kinesin activity is important to ensure their proper functioning, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::945201c99743b0afc488ed5d146b214a
https://dspace.library.uu.nl/handle/1874/343660
https://dspace.library.uu.nl/handle/1874/343660
Publikováno v:
Biochemical Society transactions. 41(6)
Neurons are highly specialized for the processing and transmission of electrical signals and use cytoskeleton-based motor proteins to transport different vesicles and cellular materials. Abnormalities in intracellular transport are thought to be a cr
Myosin-V Opposes Microtubule-Based Cargo Transport and Drives Directional Motility on Cortical Actin
Autor:
Phebe S. Wulf, Joanna Lipka, Anna Akhmanova, Nanda Keijzer, Petra van Bergeijk, Casper C. Hoogenraad, Eugene A. Katrukha, Lukas C. Kapitein
Publikováno v:
Current Biology, 23(9), 828-834. Cell Press
Summary Intracellular transport is driven by motor proteins that either use microtubules or actin filaments as their tracks [1], but the interplay between these transport pathways is poorly understood [2–4]. Whereas many microtubule-based motors ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::296502c5905e34774627961fe0c9634a
https://pure.eur.nl/en/publications/1adb6065-b3f5-4521-b4aa-4c82258649e5
https://pure.eur.nl/en/publications/1adb6065-b3f5-4521-b4aa-4c82258649e5
Autor:
Kensuke Futai, Corette J. Wierenga, Takuya Watanabe, Philipp Schätzle, Marta Esteves da Silva, Casper C. Hoogenraad, Max Adrian, Sukhee Cho, Lukas C. Kapitein, Joanna Lipka
Publikováno v:
Cell Reports, Vol 13, Iss 5, Pp 933-943 (2015)
Cell Reports [E], 13(5), 933. Elsevier Saunders
Cell Reports, 13(5), 933-943. Cell Press
Cell Reports [E], 13(5), 933. Elsevier Saunders
Cell Reports, 13(5), 933-943. Cell Press
SummaryLateral diffusion in the membrane and endosomal trafficking both contribute to the addition and removal of AMPA receptors (AMPARs) at postsynaptic sites. However, the spatial coordination between these mechanisms has remained unclear, because