Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Joanna Leonard"'
Autor:
Richard J. K. Taylor, John Clifford Head, James Thomas Reuberson, Brian Hutchinson, P. Turner, E.C. Boyd, M.A.W. Eaton, B. Hughes, G. Higgs, John Robert Porter, Alex Zomaya, Neil Gozzard, R.A. Allen, Rikki Peter Alexander, Andrew T. Millican, M. Wales, R. Morphy, Joanna Leonard, A. Cannell, Julien Alistair Brown, Martin J. Perry, Byron A. Boyce, Barbara Mason, D. Barnes, Graham John Warrellow
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1451-1456
The discovery, synthesis and biological activity of a series of triarylethane phosphodiesterase 4 inhibitors is described. Structure-activity relationship studies are presented for CDP840 (29), a potent, chiral, selective inhibitor of PDE 4 (IC(50) 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d1a5dd3d9373fea6d98706204952b2
https://doi.org/10.1016/s0960-894x(02)00202-0
https://doi.org/10.1016/s0960-894x(02)00202-0
Autor:
James O'Connell, Byron A. Boyce, Pari Antoniw, John Robert Porter, Andrew Mountain, Surinder K. Chander, Kenneth Millar, Richard Morphy, Barbara Mason, Neville Willmott, Nigel Robert Arnold Beeley, Joanna Leonard, Thomas Crabbe, Andrew T. Millican, Andrew J. P. Docherty
Publikováno v:
Journal of Pharmaceutical Sciences. 84:404-409
Gelatinase A, a matrix metalloproteinase, is frequently associated with human solid tumors, and its secretion and activation in the tumor milieu is considered important in the process of angiogenesis, invasion, and metastasis. Consequently, metallopr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2b9d49b17daa1ab88c55ae679150c8a
https://doi.org/10.1002/jps.2600840405
https://doi.org/10.1002/jps.2600840405
Autor:
Byron A. Boyce, Nigel Robert Arnold Beeley, J. Richard Morphy, Andrew T. Millican, Joanna Leonard, Barbara Mason, Kenneth Millar, John Robert Porter, O'connell James Philip
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2747-2752
A series of zinc binding groups was introduced into a pseudopeptide sequence containing aromatic groups in the P1′ position in order to obtain selective inhibitors of gelatinase-A. Carboxylic acid and phosphonic acid groups provided the most potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cb5c9f340d96dd6d0ec92d0ab252ea4
https://doi.org/10.1016/s0960-894x(01)80588-6
https://doi.org/10.1016/s0960-894x(01)80588-6
Autor:
Kenneth Millar, Joanna Leonard, O'connell James Philip, Andrew T. Millican, Byron A. Boyce, J. Richard Morphy, Barbara Mason, John Robert Porter, Nigel Robert Arnold Beeley
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2741-2746
A series of hydroxamic acid derivatives were prepared. By introducing aromatic substituents at the P1′ and P3′ positions highly potent gelatinase-A inhibitors, which possess a high degree of selectivity over collagenase and stromelysin, were obta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38749fe0dc2358bdc8bfcbcf20b91e62
https://doi.org/10.1016/s0960-894x(01)80587-4
https://doi.org/10.1016/s0960-894x(01)80587-4
Publikováno v:
The Australian journal of advanced nursing : a quarterly publication of the Royal Australian Nursing Federation. 24(4)
Health systems throughout much of the world have been subject to 'reform' in recent years as countries have attempted to contain the rapidly rising costs of health care. Changes to hospital structures (restructuring) have been an important part of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::41977daddfa96896081b58774ab014f5
https://pubmed.ncbi.nlm.nih.gov/17682413
https://pubmed.ncbi.nlm.nih.gov/17682413