Výsledky vyhledávání

Daratumumab (Dara), Cyclophosphamide, Thalidomide and Dexamethasone for Transplant Eligible Newly Diagnosed Multiple Myeloma (TE NDMM) Patients: Response Rate Impacts on PFS

Autor: Edvan De Queiroz Crusoe, Joanna Leal, Juliana Andrade Santos, Herbert Henrique de Melo Santos, Allan de souza Santos, Larissa Ferreira Lucas, Alessandro de M. Almeida, Marcos Chaves, Daniela Dourado Dutra, Vania T.M. Hungria, Marco Aurelio Salvino, Maria da Gloria B. Arruda

Publikováno v: Blood. 140:7699-7700

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0c67368afa132c42a81b030b371f94b
https://doi.org/10.1182/blood-2022-164866

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Progression Free Survival (PFS) Analysis of Daratumumab (Dara), Cyclophosphamide, Thalidomide and Dexamethasone: A Quadruplet Intensified Treatment for Transplant Eligible Newly Diagnosed Multiple Myeloma (TE NDMM) Patients

Autor: J. Santos, Allan de souza Santos, Vania Hungria, L. Lucas, M. R. Chaves, Herbert Henrique de Melo Santos, Alessandro de Moura Almeida, Edvan de Queiroz Crusoe, Cleverson Alves Fonseca, Sarah Queiroz Silva, M. Santos, Joanna Leal, Marco Aurelio Salvino, Maria da Gloria B. Arruda, Lucas de Oliveira Vieira, Elisangela Adorno

Publikováno v: Blood. 138:3943-3943

Background: Newly drugs access for MM treatment still a challenge in some countries. One of the most available inductions for TE NDMM patients (pts) worldwide is cyclophosphamide (C), thalidomide (T) and dexamethasone (d)-(CTd). Dara the first anti-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6014f225d431a8ee74063acb5325df2d
https://doi.org/10.1182/blood-2021-150607

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Evaluation of Hematopoietic Stem Cell Product As a New Site for Minimal Residual Disease By Next Generation Flow in Multiple Myeloma

Autor: Edvan de Queiroz Crusoe, Allan de souza Santos, Maria da Gloria B. Arruda, Herbert Henrique de Melo Santos, Marco Aurelio Salvino, Joanna Leal, M. Santos, Glaciano Ribeiro, M. R. Chaves, J. Santos, Alessandro de Moura Almeida, Vania Hungria

Publikováno v: Blood. 138:4927-4927

Introduction- Next generation flow (NGF) is one of the approaches for testing multiple myeloma (MM) minimal residual disease (MRD) over conventional response assessments. Actually, bone marrow (BM) is the preference site of evaluation because of its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2496dfbc1a49451909d45a42c3dd9153
https://doi.org/10.1182/blood-2021-154129

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P-173: Impact of Daratumumab (DARA) administration during transplant-eligible newly diagnosed Multiple Myeloma (TE NDMM) induction on stem cell (SC) mobilization count and post-transplant engraftment

Autor: M. R. Chaves, L. Lucas, J. Santos, Alex Álisson Bandeira Santos, Aglaya Oliveira Lima Cordeiro de Almeida, M. Santos, Edvan de Queiroz Crusoe, Marco Aurelio Salvino, Herbert Henrique de Melo Santos, Guimarães Vi, D. Dourado, J. Nicanor, Joanna Leal, M. da Gloria Arruda

Publikováno v: Clinical Lymphoma Myeloma and Leukemia. 21:S131

In the MAX Dara study, Dara-CTd was used sequentially close to the pre- and post-ASCT (D-30 and D + 30), in order to take advantage of the Dara as an in vivo purge. However, dara could interfer in the SC collection and bone marrow engraftment. In thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c2511c05079ca691e1eb183c113d38a
https://doi.org/10.1016/s2152-2650(21)02300-4

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P-172: Daratumumab (Dara), Cyclophosphamide, Thalidomide and Dexamethasone: a quadruplet intensified treatment for transplant eligible newly diagnosed Multiple Myeloma (TE NDMM) patients final results

Autor: M. da Gloria Arruda, L. Lucas, Luis Eduardo Antunes Vieira, J. Santos, Joanna Leal, Marco Aurélio Salvino, Elisângela Vitória Adorno, Cleverson Alves Fonseca, Herbert Henrique de Melo Santos, M. Santos, Edvan de Queiroz Crusoe, Sarah Queiroz, Vania Hungria, Aglaya Oliveira Lima Cordeiro de Almeida, Alex Álisson Bandeira Santos

Publikováno v: Clinical Lymphoma Myeloma and Leukemia. 21:S130

Background Newly drugs access for MM treatment still a challenge. One of the available inductions for TE NDMM patients (pts) worldwide is cyclophosphamide (C), thalidomide (T) and dexamethasone (d)- (CTd). We hypothesized that the Daratumumab and CTd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2de3673355efd275de5933072dc6d82e
https://doi.org/10.1016/s2152-2650(21)02299-0

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P-066: Effect of Daratumumab (DARA), Cyclophosphamide (C), T Halidomide (T) and Dexamethasone (D) combination of Lymphocyte populations of transplant eligible newly diagnosed Multiple Myeloma patients

Autor: Allan Souza dos Santos, Juliana Maria Oliveira dos Santos, L. Lucas, Herbert Henrique de Melo Santos, Edvan de Queiroz Crusoe, Joanna Leal, M. Santos, Maria da Gloria B. Arruda, Alex José Leite Torres, Sarah Queiroz, Marco Aurelio Salvino, Alessandro de Moura Almeida

Publikováno v: Clinical Lymphoma Myeloma and Leukemia. 21:S75

Background The CTD combination have both an immunomodulatory and immunosuppressive activity on multiple myeloma (MM) patients (pts) treatment. Dara, an antiCD38-antibody, effect on the immune system was already described, but few studies analyzed spe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c014c233d01973eb85d786b927773b4
https://doi.org/10.1016/s2152-2650(21)02200-x

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Preliminary Results of Daratumumab, Cyclophosphamide, Thalidomide and Dexamethasone: A Quadruplet Intensified Treatment for Newly Diagnosed Multiple Myeloma (NDMM) Transplant Eligible (TE) Patients

Autor: Edvan De Queiroz Crusoe, Marco Aurelio Salvino, Sarah Queiroz Silva, Herbert Henrique de Melo Santos, Allan de souza Santos, Alessandro de M. Almeida, Lucas de Oliveira Vieira, Cleverson Alves Fonseca, Larissa Ferreira Lucas, Joanna Leal, Mariane Melo Santos, Juliana Andrade Santos, Elisangela Adorno, Vania T. M. Hungria, Maria da Gloria B. Arruda

Publikováno v: Blood. 136:17-18

Background: The inclusion of the CD38-targeting antibody daratumumab (Dara) increases the depth and duration of the response, as demonstrated by Dara-VTd and Dara-VRd protocols to treat NDMM - TE patients (pts). However, the access to new drugs is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9cdef482a1c3ff8e913e18ef84ab05f8
https://doi.org/10.1182/blood-2020-138873

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Genotoxic and mutagenic effects of guarana (Paullinia cupana) in prokaryotic organisms

Autor: Alvaro C. Leitão, Sônia Soares Costa, C. A. S. Da Fonseca, Joanna Leal

Publikováno v: Mutation Research/Genetic Toxicology. 321:165-173

Aqueous extracts of Paullinia cupana (guarana), a species that belongs to the Sapindaceae family, were analyzed for the presence of genotoxic activities in bacterial cells. The extracts of guarana were genotoxic as assessed by lysogenic induction in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6a2f395f1b4365060fb0af88b7a627
https://doi.org/10.1016/0165-1218(94)90041-8

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