Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Joanna Lapczuk-Romanska"'
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 17, p 6404 (2020)
Environmental factors contribute to autoimmune disease manifestation, and as regarded today, AhR has become an important factor in studies of immunomodulation. Besides immunological aspects, AhR also plays a role in pharmacological, toxicological and
Externí odkaz:
https://doaj.org/article/72412ab92b744b94ab529f736e1c98f7
Autor:
Marek Droździk, Sylwia Szeląg-Pieniek, Justyna Grzegółkowska, Joanna Łapczuk-Romańska, Mariola Post, Pawel Domagała, Janusz Miętkiewski, Stefan Oswald, Mateusz Kurzawski
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1606 (2020)
Membrane monocarboxylate transporter 1 (SLC16A1/MCT1) plays an important role in hepatocyte homeostasis, as well as drug handling. However, there is no available information about the impact of liver pathology on the transporter levels and function.
Externí odkaz:
https://doaj.org/article/86d54646980a4b6e81c1af1bd57ca1fb
Autor:
Marek Drozdzik, Joanna Lapczuk-Romanska, Christoph Wenzel, Lukasz Skalski, Sylwia Szeląg-Pieniek, Mariola Post, Arkadiusz Parus, Marta Syczewska, Mateusz Kurzawski, Stefan Oswald
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4543 (2023)
Hepatic drug metabolizing enzymes (DMEs), whose activity may be affected by liver diseases, are major determinants of drug pharmacokinetics. Hepatitis C liver samples in different functional states, i.e., the Child–Pugh class A (n = 30), B (n = 21)
Externí odkaz:
https://doaj.org/article/7afe6b9a50bc4df0bc1e924080b91291
Autor:
Marek Droździk, Joanna Lapczuk-Romanska, Christoph Wenzel, Łukasz Skalski, Sylwia Szeląg-Pieniek, Mariola Post, Marta Syczewska, Mateusz Kurzawski, Stefan Oswald
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7947 (2022)
Transmembrane drug transport in hepatocytes is one of the major determinants of drug pharmacokinetics. In the present study, ABC transporters (P-gp, MRP1, MRP2, MRP3, MRP4, BCRP, and BSEP) and SLC transporters (MCT1, NTCP, OAT2, OATP1B1, OATP1B3, OAT
Externí odkaz:
https://doaj.org/article/fa8c5606dbee4c3abc2d7ebfa2367d31
Autor:
Marek Drozdzik, Joanna Lapczuk-Romanska, Christoph Wenzel, Sylwia Szelag-Pieniek, Mariola Post, Łukasz Skalski, Mateusz Kurzawski, Stefan Oswald
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1334 (2021)
Hepatic drug metabolizing enzymes (DMEs) markedly affect drug pharmacokinetics. Because liver diseases may alter enzymatic function and in turn drug handling and clinical efficacy, we investigated DMEs expression in dependence on liver pathology and
Externí odkaz:
https://doaj.org/article/5d8fca0e121047dd9394a9be7c6ec67c
Autor:
Joanna Lapczuk-Romanska, Diana Busch, Ewa Gieruszczak, Agnieszka Drozdzik, Katarzyna Piotrowska, Robert Kowalczyk, Stefan Oswald, Marek Drozdzik
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 19, p 4825 (2019)
Salivary glands provide secretory functions, including secretion of xenobiotics and among them drugs. However, there is no published information about protein abundance of drug transporters measured using reliable protein quantification methods. Ther
Externí odkaz:
https://doaj.org/article/05471fab576c4287ad8f5ca42bf003ef
Autor:
Mateusz Kurzawski, Christoph Wenzel, Mariola Post, Joanna Lapczuk-Romanska, Stefan Oswald, Marek Drozdzik, Sylwia Szelag-Pieniek, Łukasz Skalski
Publikováno v:
Pharmaceutics
Volume 13
Issue 9
Pharmaceutics, Vol 13, Iss 1334, p 1334 (2021)
Volume 13
Issue 9
Pharmaceutics, Vol 13, Iss 1334, p 1334 (2021)
Hepatic drug metabolizing enzymes (DMEs) markedly affect drug pharmacokinetics. Because liver diseases may alter enzymatic function and in turn drug handling and clinical efficacy, we investigated DMEs expression in dependence on liver pathology and
Autor:
Robert Kowalczyk, Ewa Gieruszczak, Stefan Oswald, Marek Drozdzik, Joanna Lapczuk-Romanska, Diana Busch, Katarzyna Piotrowska, Agnieszka Drozdzik
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 19, p 4825 (2019)
Volume 20
Issue 19
International Journal of Molecular Sciences, Vol 20, Iss 19, p 4825 (2019)
Volume 20
Issue 19
Salivary glands provide secretory functions, including secretion of xenobiotics and among them drugs. However, there is no published information about protein abundance of drug transporters measured using reliable protein quantification methods. Ther
Autor:
Maryam Gholizadeh, Joanna Łapczuk-Romańska, Mariola Post, Nina Komaniecka, Seyed Reza Mazlooman, Lars Kaderali, Marek Droździk
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7207 (2023)
Given the substantial correlation between early diagnosis and prolonged patient survival in HCV patients, it is vital to identify a reliable and accessible biomarker. The purpose of this research was to identify accurate miRNA biomarkers to aid in th
Externí odkaz:
https://doaj.org/article/c2923e5eae8547dbb48715773124e9de
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2856 (2023)
The kidney functions not only as a metabolite elimination organ but also plays an important role in pharmacotherapy. The kidney tubule epithelia cells express membrane carriers and transporters, which play an important role in drug elimination, and c
Externí odkaz:
https://doaj.org/article/faf28b5258674d28a73bffb29b6c28b9