Supplementary Materials and Methods from Constitutive Activation of Myosin-Dependent Contractility Sensitizes Glioma Tumor-Initiating Cells to Mechanical Inputs and Reduces Tissue Invasion

Autor: Sanjay Kumar, Brent A. Reynolds, Musa A. Jundi, Regina T. Martuscello, Jung-Ming G. Lin, Joanna L. MacKay, Loic P. Deleyrolle, Theresa A. Ulrich, Sophie Y. Wong

Supplementary Materials and Methods. Description of additional methods and procedures used in the study.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb225f926e71a68c4f4a566fdb173d5
https://doi.org/10.1158/0008-5472.22408154

Supplementary Figure S2 from Constitutive Activation of Myosin-Dependent Contractility Sensitizes Glioma Tumor-Initiating Cells to Mechanical Inputs and Reduces Tissue Invasion

Autor: Sanjay Kumar, Brent A. Reynolds, Musa A. Jundi, Regina T. Martuscello, Jung-Ming G. Lin, Joanna L. MacKay, Loic P. Deleyrolle, Theresa A. Ulrich, Sophie Y. Wong

Supplementary Figure S2. BMP4-induced differentiation alters tumor-initiating cell spread area, but not motility.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16138a2cb4f69bc2551219ce7ebf958f
https://doi.org/10.1158/0008-5472.22408157

Data from Constitutive Activation of Myosin-Dependent Contractility Sensitizes Glioma Tumor-Initiating Cells to Mechanical Inputs and Reduces Tissue Invasion

Autor: Sanjay Kumar, Brent A. Reynolds, Musa A. Jundi, Regina T. Martuscello, Jung-Ming G. Lin, Joanna L. MacKay, Loic P. Deleyrolle, Theresa A. Ulrich, Sophie Y. Wong

Tumor-initiating cells (TIC) perpetuate tumor growth, enable therapeutic resistance, and drive initiation of successive tumors. Virtually nothing is known about the role of mechanotransductive signaling in controlling TIC tumorigenesis, despite the r

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https://doi.org/10.1158/0008-5472.c.6507473.v1

Constitutive Activation of Myosin-Dependent Contractility Sensitizes Glioma Tumor-Initiating Cells to Mechanical Inputs and Reduces Tissue Invasion

Autor: Musa A. Jundi, Joanna L. MacKay, Loic P. Deleyrolle, Brent A. Reynolds, Jung-Ming G. Lin, Theresa A. Ulrich, Sophie Y. Wong, Regina T. Martuscello, Sanjay Kumar

Publikováno v: Wong, SY; Ulrich, TA; Deleyrolle, LP; MacKay, JL; Lin, JMG; Martuscello, RT; et al.(2015). Constitutive activation of myosin-dependent contractility sensitizes glioma tumor-initiating cells to mechanical inputs and reduces tissue invasion. Cancer Research, 75(6), 1113-1122. doi: 10.1158/0008-5472.CAN-13-3426. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/3bc992cb
Cancer research, vol 75, iss 6

Tumor-initiating cells (TIC) perpetuate tumor growth, enable therapeutic resistance, and drive initiation of successive tumors. Virtually nothing is known about the role of mechanotransductive signaling in controlling TIC tumorigenesis, despite the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6a1bc29cba9bcdaac4a54c33246198
https://doi.org/10.1158/0008-5472.can-13-3426

Simultaneous and independent tuning of RhoA and Rac1 activity with orthogonally inducible promoters

Autor: Sanjay Kumar, Joanna L. MacKay

Publikováno v: Integrative Biology. 6:885-894

The GTPases RhoA and Rac1 are key regulators of cell spreading, adhesion, and migration, and they exert distinct effects on the actin cytoskeleton. While RhoA classically stimulates stress fiber assembly and contraction, Rac1 promotes branched actin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edc567d5ef2a4030e4761936dff09bb0
https://doi.org/10.1039/c4ib00099d