Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Joanna L. Kaplan"'
Autor:
Victor N. Rivas, Amanda E. Crofton, Carina E. Jauregui, Jalena R. Wouters, Betty S. Yang, Luke A. Wittenburg, Joanna L. Kaplan, Darren T. Hwee, Anne N. Murphy, Bradley P. Morgan, Fady I. Malik, Samantha P. Harris, Joshua A. Stern
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Hypertrophic cardiomyopathy (HCM) remains the most common cardiomyopathy in humans and cats with few preclinical pharmacologic interventional studies. Small-molecule sarcomere inhibitors are promising novel therapeutics for the management of
Externí odkaz:
https://doaj.org/article/1940ab1525324fb69489f617ae0a6c84
Autor:
Danika L. Bannasch, Danielle T. Oertle, Julia Vo, Kevin L. Batcher, Joshua A. Stern, Joanna L. Kaplan, Ronald H. L. Li, Indiana E. Madden, Matthias Christen, Tosso Leeb, Nikhil Joshi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Dilated cardiomyopathy (DCM) is characterized by decreased systolic function and dilation of one or both ventricles, often leading to heart failure or sudden death. Two 10-month-old sibling Nova Scotia Duck Tolling Retrievers (NSDTR) died ac
Externí odkaz:
https://doaj.org/article/ef7067c58fce4a5db32de339fd96ab57
Autor:
Joshua A. Stern, Victor N. Rivas, Joanna L. Kaplan, Yu Ueda, Maureen S. Oldach, Eric S. Ontiveros, Kristina B. Kooiker, Sabine J. van Dijk, Samantha P. Harris
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract We sought to establish a large animal model of inherited hypertrophic cardiomyopathy (HCM) with sufficient disease severity and early penetrance for identification of novel therapeutic strategies. HCM is the most common inherited cardiac dis
Externí odkaz:
https://doaj.org/article/5b4799ad46954d248634d5801bbc9c0c
Autor:
Ronald H. L. Li, Arianne Fabella, Nghi Nguyen, Joanna L. Kaplan, Eric Ontiveros, Joshua A. Stern
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 37, Iss 2, Pp 490-502 (2023)
Abstract Background Cats with hypertrophic cardiomyopathy (HCM) are at risk of cardiogenic arterial thromboembolism (CATE). Neutrophil extracellular traps (NETs) may be a potential biomarker and therapeutic target for cardiomyopathy in cats. Hypothes
Externí odkaz:
https://doaj.org/article/6699135952e842e4a9abaa77200557df
Autor:
Ashley N. Sharpe, Maureen S. Oldach, Victor N. Rivas, Joanna L. Kaplan, Ashley L. Walker, Samantha L. Kovacs, Darren T. Hwee, Peadar Cremin, Bradley P. Morgan, Fady I. Malik, Samantha P. Harris, Joshua A. Stern
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Hypertrophic cardiomyopathy (HCM) is the most prevalent inherited cardiac disease in humans and cats and lacks efficacious pharmacologic interventions in the preclinical phase of disease. LV outflow tract obstruction (LVOTO) is commonly obse
Externí odkaz:
https://doaj.org/article/3ef6018c3c88481d88035def01a77db8
Autor:
Joanna L. Kaplan, Lance C. Visser, Catherine T. Gunther‐Harrington, Eric S. Ontiveros, Luke A. Wittenburg, Carrie A. Palm, Joshua A. Stern
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 36, Iss 6, Pp 1892-1899 (2022)
Abstract Background Pimobendan might have favorable effects on renal function but this has not been well‐studied in dogs with myxomatous mitral valve disease (MMVD). Objectives Determine the effects of standard‐dose (SD_pimo) and high‐dose pimo
Externí odkaz:
https://doaj.org/article/541c5d9eb41d4549b531325e7b087ef2
Autor:
Victor N. Rivas, Joanna L. Kaplan, Susan A. Kennedy, Stuart Fitzgerald, Amanda E. Crofton, Aisling Farrell, Louise Grubb, Carina E. Jauregui, Gabriela Grigorean, Eunju Choi, Samantha P. Harris, Joshua A. Stern
Publikováno v:
Animals, Vol 13, Iss 20, p 3184 (2023)
Hypertrophic cardiomyopathy (HCM) remains the single most common cardiomyopathy in cats, with a staggering prevalence as high as 15%. To date, little to no direct therapeutical intervention for HCM exists for veterinary patients. A previous study aim
Externí odkaz:
https://doaj.org/article/403394af55fc4f298708d13b779dce13
Autor:
Joseph S. Raleigh, William T. N. Culp, Rachel Brady, Sami Al‐Nadaf, Michael S. Kent, Joanna L. Kaplan, Joshua A. Stern, Lance C. Visser, Kevin D. Niedringhaus, Tatiana G. Wolf, Eunju Choi, Verena K. Affolter
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 35, Iss 3, Pp 1536-1541 (2021)
Abstract A 10‐year‐old female spayed mixed breed dog was evaluated for diarrhea and vomiting. Diagnostic imaging demonstrated the presence of an intracardiac mass. A modified Seldinger technique was used to access the right jugular vein, and an e
Externí odkaz:
https://doaj.org/article/42f28e86163a4fa78d23ca5890268dae
Publikováno v:
BMC Veterinary Research, Vol 14, Iss 1, Pp 1-9 (2018)
Abstract Background The teratogenic effects of immunomodulatory and certain antimicrobial therapies are described in small rodents and humans. While the described teratogenic effects in small rodents have been extrapolated to make conclusions about i
Externí odkaz:
https://doaj.org/article/9f25df10e4b14e80a48c2399187f01a5
Autor:
Ashley N. Sharpe, Maureen S. Oldach, Joanna L. Kaplan, Victor Rivas, Samantha L. Kovacs, Darren T. Hwee, Bradley P. Morgan, Fady I. Malik, Samantha P. Harris, Joshua A. Stern
Publikováno v:
Journal of veterinary pharmacology and therapeuticsREFERENCES.
Hypertrophic cardiomyopathy (HCM) is the most prevalent cardiac disease in cats and lacks efficacious preclinical pharmacologic intervention, prompting investigation of novel therapies. Genetic mutations encoding sarcomeric proteins are implicated in