Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Joanna L. Fox"'
Autor:
Joanna L. Fox, Michelle A. Hughes, Xin Meng, Nikola A. Sarnowska, Ian R. Powley, Rebekah Jukes-Jones, David Dinsdale, Timothy J. Ragan, Louise Fairall, John W. R. Schwabe, Nobuhiro Morone, Kelvin Cain, Marion MacFarlane
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The core FADD:Caspase-8 complex and its regulatory partners, such as the cell death inhibitor c-FLIP, coordinate cell fate. Here authors present the structure of full-length procaspase-8 in a complex with FADD and reveal how recruitment of c-FLIPS in
Externí odkaz:
https://doaj.org/article/cbf43a167d5c47dbbf9efdc46a691fd7
Publikováno v:
Cancers, Vol 14, Iss 11, p 2745 (2022)
When a cell is damaged, it must decide how to respond. As a consequence of a variety of stresses, cells can induce well-regulated programmes such as senescence, a persistent proliferative arrest that limits their replication. Alternatively, regulated
Externí odkaz:
https://doaj.org/article/b1cfc5167c724eb59effc0d4c5bdc70d
Autor:
Alan Storey, Joanna L. Fox
Supplementary Figure S1. Controls for co-immunoprecipitation of BAK-BMX complex. Supplementary Figure S2. Immunoprecipitation of BMX protein from HT1080 cells did not detect BAX associated with BMX. Input for immunoprecipitation reaction is 10% start
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305c98eeb0fc34bd50f089ad2e59a97b
https://doi.org/10.1158/0008-5472.22408775.v1
https://doi.org/10.1158/0008-5472.22408775.v1
Autor:
Alan Storey, Joanna L. Fox
The ability of chemotherapeutic agents to induce apoptosis, predominantly via the mitochondrial (intrinsic) apoptotic pathway, is thought to be a major determinant of the sensitivity of a given cancer to treatment. Intrinsic apoptosis, regulated by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ddf34e4f36c7d1518255801c6f68288
https://doi.org/10.1158/0008-5472.c.6507617
https://doi.org/10.1158/0008-5472.c.6507617
Autor:
Marion MacFarlane, Joanna L. Fox
Publikováno v:
British Journal of Cancer
Targeting apoptosis for the treatment of cancer has become an increasingly attractive strategy, with agents in development to trigger extrinsic apoptosis via TRAIL signalling, or to prevent the anti-apoptotic activity of BCL-2 proteins or inhibitor o
Autor:
Alan Storey, Joanna L. Fox
Publikováno v:
Cancer Research. 75:1345-1355
The ability of chemotherapeutic agents to induce apoptosis, predominantly via the mitochondrial (intrinsic) apoptotic pathway, is thought to be a major determinant of the sensitivity of a given cancer to treatment. Intrinsic apoptosis, regulated by t
Publikováno v:
International Journal of Cancer. 136:2831-2843
UV exposure is the main etiological agent in the development of non-melanoma skin cancer (NMSC), but mounting evidence suggests a co-factorial role for β-genus HPV types early in tumor initiation or progression. UV damage initiates an apoptotic resp
Autor:
Joanna L Fox
Publikováno v:
Journal of Cell Signaling.
Autor:
Joanna L. Fox
Publikováno v:
Oncoscience
Blocking or evading apoptosis is one of the hallmarks of cancer [1]. Recent advances in genomic sequencing have identified many mutations in cancer cells, prompting an increased effort to identify driver mutations in critical pathways that impact upo
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49601 (2012)
PLoS ONE
PLoS ONE
The BCL-2 family protein BAK is a key regulator of mitochondrial apoptosis. BAK activation first involves N-terminal conformational changes that lead to the transient exposure of the BAK BH3 domain that then inserts into a hydrophobic groove on anoth