Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Joanna L James"'
Autor:
Anna Leabourn Boss, Tanvi Damani, Tayla J Wickman, Larry W Chamley, Joanna L James, Anna ES Brooks
Publikováno v:
eLife, Vol 11 (2022)
Single-cell technologies (RNA-sequencing, flow cytometry) are critical tools to reveal how cell heterogeneity impacts developmental pathways. The placenta is a fetal exchange organ, containing a heterogeneous mix of mesenchymal cells (fibroblasts, my
Externí odkaz:
https://doaj.org/article/a914d2c5624f45fdabd27a7ff2f97876
Autor:
Beth Holder, John D. Aplin, Nardhy Gomez-Lopez, Alexander E. P. Heazell, Joanna L. James, Carolyn J. P. Jones, Helen Jones, Rohan M. Lewis, Gil Mor, Claire T. Roberts, Sarah A. Robertson, Ana C. Zenclussen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-5 (2021)
Externí odkaz:
https://doaj.org/article/d028fc2854be4df5839f2a789d23e013
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Abstract Fetal growth restriction (FGR) affects 5–10% of pregnancies, leading to clinically significant fetal morbidity and mortality. FGR placentae frequently exhibit poor vascular branching, but the mechanisms driving this are poorly understood.
Externí odkaz:
https://doaj.org/article/7a25616f991b4c4896ea62f5f50b0dca
Autor:
Teena K. J. B. Gamage, William Schierding, Daniel Hurley, Peter Tsai, Jackie L. Ludgate, Chandrakanth Bhoothpur, Lawrence W. Chamley, Robert J. Weeks, Erin C. Macaulay, Joanna L. James
Publikováno v:
Epigenetics, Vol 13, Iss 12, Pp 1154-1173 (2018)
The placenta is a vital fetal exchange organ connecting mother and baby. Specialised placental epithelial cells, called trophoblasts, are essential for adequate placental function. Trophoblasts transform the maternal vasculature to allow efficient bl
Externí odkaz:
https://doaj.org/article/128c01ec68fe4a9784aedbd76ec11c86
Publikováno v:
International Journal of Therapeutic Massage & Bodywork: Research, Education, & Practice. 16:30-43
Miscarriage is a relatively common occurrence, impacting 8–15% of clinically recognised pregnancies, and up to 30% of all conceptions. The public perception of the risk factors associated with miscarriage does not match the evidence. Evidence indic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a90c27eb81b048bbc47f858f8fbb0d15
https://doi.org/10.3822/ijtmb.v16i1.771
https://doi.org/10.3822/ijtmb.v16i1.771
Publikováno v:
Annals of Biomedical Engineering. 51:1256-1269
The placenta is a critical fetal exchange organ, with a complex branching tree-like structure. Its surface is covered by a single multinucleated cell, the syncytiotrophoblast, which bathes in maternal blood for most of pregnancy. Mechanosensing prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d5a93b68c4087b36b87ab298673efb
https://doi.org/10.1007/s10439-022-03129-2
https://doi.org/10.1007/s10439-022-03129-2
Autor:
Mancy Tong, Shi-bin Cheng, Qi Chen, Joana DeSousa, Peter R. Stone, Joanna L. James, Lawrence W. Chamley, Surendra Sharma
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract In preeclampsia, the serum levels of transthyretin, a carrier protein for thyroxine, are elevated. Transthyretin isolated from preeclamptic serum is also aggregated and can induce preeclampsia-like symptoms in pregnant IL10−/− mice. Usin
Externí odkaz:
https://doaj.org/article/d86da9a98d17490480dbca830c152fcc
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 323:H72-H88
`The entire maternal circulation adapts to pregnancy, and this adaption is particularly extensive in the uterine circulation where the major vessels double in size to facilitate an approximately 15-fold increase in blood supply to this organ over the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9a33b6a23090411201871f03a06f497
https://doi.org/10.1152/ajpheart.00693.2021
https://doi.org/10.1152/ajpheart.00693.2021
Autor:
Joanna L. James, Joshua J. Fisher
Publikováno v:
Placenta. 125:78-83
Career trajectories in science are often unpredictable, with many early and mid-career researchers working multiple successive fixed-term contracts, and physically relocating to take up employment opportunities. Whilst this can provide exciting oppor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6384830b939b0bc54c7542a74b63e8
https://doi.org/10.1016/j.placenta.2021.10.013
https://doi.org/10.1016/j.placenta.2021.10.013
Publikováno v:
Placenta. 125:68-77
Early placental development lays the foundation of a healthy pregnancy, and numerous tightly regulated processes must occur for the placenta to meet the increasing nutrient and oxygen exchange requirements of the growing fetus later in gestation. Ina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c5dae2df90df4f5d89c3a8464ea7594
https://doi.org/10.1016/j.placenta.2021.11.004
https://doi.org/10.1016/j.placenta.2021.11.004