Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Joanna L, Giles"'
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
The membrane attack complex (MAC) is an immune effector that kills pathogens by forming pores in their membrane. Here the authors use cryo-electron microscopy to reveal that the full MAC is an asymmetric pore with a split-washer configuration and ide
Externí odkaz:
https://doaj.org/article/c1758f53fff24aeaa7aaf0764e26cd76
Autor:
William Spitall, Caroline H. Chilton, April K. Roberts, Ines B Moura, Duncan Ewin, Clifford C. Shone, Emma Clark, Mark H. Wilcox, Hannah C Harris, Anthony M. Buckley, Rossen Donev, Oktawia J Polak, Michael Smith, Joanna L. Giles
Publikováno v:
Frontiers in Microbiology
Frontiers in Microbiology, Vol 11 (2020)
Frontiers in Microbiology, Vol 11 (2020)
Clostridioides difficile infection (CDI) is a toxin-mediated infection in the gut and a major burden on healthcare facilities worldwide. We rationalized that it would be beneficial to design an antibody therapy that is delivered to, and is active at
Publikováno v:
Advances in protein chemistry and structural biology. 120
The rheumatological diseases are a group of chronic, painful, degenerative and debilitating conditions with an increasing prevalence across the globe. The pathogenesis of these disorders is complex, overlapping and not fully understood. As such, it i
Publikováno v:
Advances in Protein Chemistry and Structural Biology ISBN: 9780128213223
The rheumatological diseases are a group of chronic, painful, degenerative and debilitating conditions with an increasing prevalence across the globe. The pathogenesis of these disorders is complex, overlapping and not fully understood. As such, it i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de16ad4f927a17e2d83b0443dbcf1edb
https://doi.org/10.1016/bs.apcsb.2019.11.007
https://doi.org/10.1016/bs.apcsb.2019.11.007
Autor:
Oliwia Rysnik, Soraya Hölper, Paul Bowness, E. Desogus, Alessandra Vacca, K McHugh, Alessandro Mathieu, Matteo Piga, P. Garau, Miguel Angel Blanco-Gelaz, Giorgio La Nasa, Jacqueline Shaw, Christoph Renner, A. Cauli, Joanna L. Giles, Sarah Fiedler, V. Ibba, Sravan Payeli, Simon Kollnberger, Hiroko Hatano, Giovanni Porru, Carlos López-Larrea, Amanda Carette, G. Dessole
Publikováno v:
Rheumatology. 52:1952-1962
Objectives. HLA-B*27:05 is associated with AS whereas HLA-B*27:09 is not associated. We hypothesized that different interactions with KIR immune receptors could contribute to the difference in disease association between HLA-B*27:05 and HLAB*27:09. T
Autor:
Christoph Renner, Sarah Keidel, Sascha Kleber, Jacqueline Shaw, Paul Bowness, Joanna L. Giles, Isabel Wong-Baeza, Andreas Wadle, Kirsty McHugh, Markus Thiel, Sravan Payeli, Osiris Marroquin Belaunzaran, A Ridley, Kimiko Kuroki, Katsumi Maenaka, Simon Kollnberger
Publikováno v:
Arthritis & Rheumatism. 64:3139-3149
OBJECTIVE: Spondylarthritides (SpA), including ankylosing spondylitis (AS), are common inflammatory rheumatic diseases that are strongly associated with positivity for the HLA class I allotype B27. HLA-B27 normally forms complexes with β(2) -microgl
Autor:
Paul Bowness, Antony N. Antoniou, Simon Kollnberger, Katilin DiGleria, A Ridley, Isabel Wong-Baeza, Katsumi Maenaka, Christopher Piper, Kimiko Kuroki, Jackie Shaw, Demin Li, Joanna L. Giles, Izabela Lenart, K McHugh
Publikováno v:
The Journal of Immunology. 188:6184-6193
Possession of HLA-B27 (B27) strongly predisposes to the development of spondyloarthritis. B27 forms classical heterotrimeric complexes with β2-microglobulin (β2m) and peptide and (β2m free) free H chain (FHC) forms including B27 dimers (termed B27
Autor:
Jackie Shaw, Christoph Renner, Waji Hassan, Robert Landewé, Carmel B. Stober, Aruna S. Malipeddi, Karen Obrenovic, Paul Creamer, Ramesh N. Jois, Katilin DiGleria, Peter Lanyon, Y. Wang, Simon Kollnberger, Leticia Lojo-Oliveira, A. Baratelle, for Assert Go-Raise Investigators, Michele Olds, Claire Sheehy, D. van der Heijde, Michael J. Green, Lotta Utriainen, Charlotte Cavill, Frances Rees, Karen Mills, N. Kerrigan, J. S. Hill Gaston, Claudia Prevosto, M. Mack, J. Braun, Philip S. Helliwell, Sravan Payeli, P. Geusens, R. Inman, Lucy Coates, S. Xu, Sarah McDonald, Paul Bowness, S. Mudivarthy, Emilio Martín-Mola, Kaushik Sanyal, Gordon Taylor, Chandra Chattopadhyay, D. Gladman, A. Beutler, Tim Key, Philip J. Mease, Paul Emery, J. Sieper, Yasser El Miedany, Frederic Lavie, Jonathan Packham, Concepción Castillo-Gallego, B. Dijkmans, Joanna L. Giles, Rebecca Neame, Cynthia Wright, Benoit Guerette, Reyna Goodman, Alessandra De Riva, Ashok K. Bhalla, Miriam García-Arias, David G. I. Scott, M. U. Rahman, Osiris Marroquin, Roman Fischer, Helen Benham, Helen MakIver, Sarah Hailwood, Katsumi Maenaka, N. Goldstein, A Brooksby, Jon Packham, W. Xu, Christopher T. Ritchlin, Deborah Palmer, Ravinder Sandhu, A. Kavanaugh, Iain B. McInnes, Kirsty McHugh, William Tillett, Karl Gaffney, A. Deodhar, N. Vastesaeger, Michael J. Deery, J. Zrubek, Robert Busch, Jane C. Goodall, Neil McHugh, Sonja Kary, P. Mease, Philip G. Conaghan, Hartmut Kupper, G. G. Krueger, Chamaida Plasencia-Rodríguez, Eugenio de Miguel Mendieta, Gamal Ibrahim, Gill Peffers, James Francis, J. Leeder, Carolyn Bell, E. Korendowych, Benedikt M. Kessler, Louise Hamilton, Nicola Erb, Jacqueline Shaw, Margaret Somerville, Karen Walker-Bone, Simon Milling, Laura C. Coates, B. Hsu
Publikováno v:
Rheumatology. 50:iii137-iii145
Background: Sacroiliac joints (SJ) involvement is a distinctive and charasteristic feature of Spondyloarthritis (SpA) and x-ray is the test routinely used to make a diagnosis. However, x-ray reveals late structural damage but cannot detect active inf
Publikováno v:
Nature Communications
In response to complement activation, the membrane attack complex (MAC) assembles from fluid-phase proteins to form pores in lipid bilayers. MAC directly lyses pathogens by a ‘multi-hit' mechanism; however, sublytic MAC pores on host cells activate
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 195(1)
In their Comment , Messemaker et al. discuss genetic data that show that block 2 within the TRAF1-C5 locus is a risk for rheumatoid arthritis (RA), while block 3 is not associated. We acknowledge these data, which illustrate that, when taken in isola