Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Joanna L, Elson"'
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Altered mito-ribosomal fidelity is an important and insufficiently understood causative agent of mitochondrial dysfunction. Its pathogenic effects are particularly well-known in the case of mitochondrially induced deafness, due to the existence of th
Externí odkaz:
https://doaj.org/article/b007bea67dea44718b4113efbed4a61a
Autor:
Antón Vila-Sanjurjo, Natalia Mallo, Joanna L. Elson, Paul M. Smith, Emma L. Blakely, Robert W. Taylor
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
The last few years have witnessed dramatic advances in our understanding of the structure and function of the mammalian mito-ribosome. At the same time, the first attempts to elucidate the effects of mito-ribosomal fidelity (decoding accuracy) in dis
Externí odkaz:
https://doaj.org/article/0dc9064d97fe48fca01699363963a7c3
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Disease caused by mutations of mitochondrial DNA (mtDNA) are highly variable in both presentation and penetrance. Over the last 30 years, clinical recognition of this group of diseases has increased. It has been suggested that haplogroup bac
Externí odkaz:
https://doaj.org/article/157b43ef8b9b40b9af19c46b65997c28
Autor:
Amica C. Müller-Nedebock, Abigail L. Pfaff, Ilse S. Pienaar, Sulev Kõks, Francois H. van der Westhuizen, Joanna L. Elson, Soraya Bardien
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Mitochondrial DNA (mtDNA), a potential source of mitochondrial dysfunction, has been implicated in Parkinson’s disease (PD). However, many previous studies investigating associations between mtDNA population variation and PD reported inconsistent o
Externí odkaz:
https://doaj.org/article/f877b442e8d1404ab7be17ae21b008da
Publikováno v:
PLoS ONE, Vol 17, Iss 10 (2022)
Several mitochondrial DNA (mtDNA) haplogroup association studies have suggested that common mtDNA variants are associated with multifactorial diseases, including Alzheimer’s disease (AD). However, such studies have also produced conflicting results
Externí odkaz:
https://doaj.org/article/abdc5486ee694025871befa58f2ebe8a
Publikováno v:
Evolutionary Applications, Vol 12, Iss 10, Pp 1912-1930 (2019)
Abstract Mitochondrial disorders are heterogeneous, showing variable presentation and penetrance. Over the last three decades, our ability to recognize mitochondrial patients and diagnose these mutations, linking genotype to phenotype, has greatly im
Externí odkaz:
https://doaj.org/article/885324715cf44333a2d9c2897493377a
Autor:
Belinda Fouché, Stephanie Turner, Rebecca Gorham, Eloise J. Stephenson, Simon Gutbier, Joanna L. Elson, Olimpo García-Beltrán, Francois H. Van Der Westhuizen, Ilse S. Pienaar
Publikováno v:
Molecular Neurobiology. 60:749-767
Coumarins are plant-derived polyphenolic compounds belonging to the benzopyrones family, possessing wide-ranging pharmaceutical applications including cytoprotection, which may translate into therapeutic potential for multiple diseases, including Par
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231136 (2020)
Myalgic encephalomyelitis/ Chronic fatigue syndrome (ME/CFS) has been associated with abnormalities in mitochondrial function. In this study we have analysed previous bioenergetics data in peripheral blood mononuclear cells (PBMCs) using new techniqu
Externí odkaz:
https://doaj.org/article/53ed0a24b5f14ef6ae57a96553535d37
Autor:
Kristina Wendelboe Olsen, Paula L. Hedley, Christian M. Hagen, Line Rode, Sophie Placing, Karen R Wøjdemann, Anne-Cathrine Shalmi, Karin Sundberg, Anne Nørremølle, Ann Tabor, Joanna L. Elson, Michael Christiansen
ObjectiveTo determine whether mitochondrial haplogroups function as disease-modifiers or as susceptibility factors in preeclampsia using a traditional haplogroup association model.MethodsThis retrospective study haplotyped 235 control and 78 preeclam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::565ceb44c913c5372151d447e97ae61e
https://doi.org/10.1101/2023.05.22.23290334
https://doi.org/10.1101/2023.05.22.23290334
Publikováno v:
PeerJ, Vol 7, p e6500 (2019)
Abnormalities in mitochondrial function have previously been shown in chronic fatigue syndrome (CFS) patients, implying that mitochondrial dysfunction may contribute to the pathogenesis of disease. This study builds on previous work showing that mito
Externí odkaz:
https://doaj.org/article/01110780b9b6467289c18da38101709b