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Aryl hydrocarbon Receptor Activation in DCs Regulates thymic Function and Immune Tolerance Induction
Publikováno v:
The Journal of Immunology. 200:46.21-46.21
The thymus is a primary immune organ that mediates central tolerance through proper education of developing thymocytes and contributes to peripheral tolerance via the production of thymic regulatory T cells (tTregs). Differentiation of thymocytes inv
Publikováno v:
The Journal of Immunology. 200:107.14-107.14
Modulation of antibody responses is often a summation of effects on B cells, helper T cells, and dendritic cells (DCs). All three of these immune cells express AhR, a ligand-activated transcription factor with endogenous and exogenous ligands known t
Publikováno v:
The Journal of Immunology. 192:112.1-112.1
Antigen recognition by CD4+ T cells leads to large-scale spatial and temporal molecular redistributions, forming the immunological synapse. We have previously shown that upon dissociation from APC, T cells capture large membrane fragments from the an