Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Joanna Klapacz"'
Autor:
Ivan Rusyn, Rebecca C Fry, Thomas J Begley, Joanna Klapacz, J Peter Svensson, Mark Ambrose, Leona D Samson
Publikováno v:
PLoS ONE, Vol 2, Iss 11, p e1252 (2007)
Upon exposure to DNA damaging agents, Saccharomyces cerevisiae respond by activating a massive transcriptional program that reflects the fact that "DNA damaging" agents also damage other cellular macromolecules. To identify the transcriptional respon
Externí odkaz:
https://doaj.org/article/adaf51ec3c1d41e3abc8730e572142ce
Autor:
Jordan S. Kozal, Heather N. Lynch, Joanna Klapacz, Rita S. Schoeny, Paul A. Jean, Andrew Maier
Publikováno v:
Chemico-Biological Interactions. :110382
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cee581970b55cbc73c99ce9dd41faa35
https://doi.org/10.1016/j.cbi.2023.110382
https://doi.org/10.1016/j.cbi.2023.110382
Autor:
B. Bhaskar Gollapudi, Joanna Klapacz
Publikováno v:
Environmental and Molecular Mutagenesis. 61:84-93
Assessment of a chemical's potential to cause permanent changes in the genetic code has been a common practice in the industry and regulatory settings for decades. Furthermore, the genetic toxicity battery of tests has typically been employed during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a6c4703fbfc27e4e804e79d74adec9
https://doi.org/10.1002/em.22318
https://doi.org/10.1002/em.22318
Autor:
Joanna Klapacz, Richard C. Pleus, Matthew J. LeBaron, Lisa M. Corey, Robert A. Budinsky, James Crissman, Rachel M. Golden, Mark Lafranconi
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 119
Studies demonstrate that with sufficient dose and duration, 1,4-dioxane (1,4-DX) induces liver tumors in laboratory rodent models. The available evidence aligns with a threshold-dependent, tumor promotion mode of action (MOA). The MOA and key events
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745bf5f74f7bf096d00ffc0fc5be03b8
https://pubmed.ncbi.nlm.nih.gov/33189748
https://pubmed.ncbi.nlm.nih.gov/33189748
Publikováno v:
Regulatory Toxicology and Pharmacology. 87:S1-S20
Diethylene glycol (DEG) is an organic chemical that is used mostly as a chemical intermediate and has minor uses as a solvent or antifreeze in consumer products; these minor uses could result in potential human exposure. Potential short and long-term
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79511e81902ae913393539efd0fc742c
https://doi.org/10.1016/j.yrtph.2017.03.027
https://doi.org/10.1016/j.yrtph.2017.03.027
Autor:
Christopher D. Heinen, Yeyejide Adeleye, Lynn H. Pottenger, Melvin E. Andersen, Paul L. Carmichael, Bevin P. Engelward, Joanna Klapacz, Rebecca A. Clewell, George E. Johnson
Publikováno v:
Mutation Research/Reviews in Mutation Research. 767:77-91
From a risk assessment perspective, DNA-reactive agents are conventionally assumed to have genotoxic risks at all exposure levels, thus applying a linear extrapolation for low-dose responses. New approaches discussed here, including more diverse and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb3b4f6e0e362de25395d359006b206
https://doi.org/10.1016/j.mrrev.2015.11.001
https://doi.org/10.1016/j.mrrev.2015.11.001
Publikováno v:
Journal of pharmacological and toxicological methods. 94(Pt 2)
While the HPLC/UV (high performance liquid chromatography coupled with ultra-violet spectrometry)-based DPRA (Direct Peptide Reactivity Assay) identifies dermal sensitizers with approximately 80% accuracy, the low selectivity and sensitivity of the H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af2eb068427a6422d14c9328b583d0e
https://pubmed.ncbi.nlm.nih.gov/30099091
https://pubmed.ncbi.nlm.nih.gov/30099091
Publikováno v:
Toxicology letters. 278
This review summarizes the hazards, exposure and risk that are associated with ethylene glycols (EGs) in their intended applications. Ethylene glycol (EG; CAS RN 107-21-1) and its related oligomers include mono-, di-, tri-, tetra-, and penta-EG. All
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01638110a27b90f64ce3aec15ec3c116
https://pubmed.ncbi.nlm.nih.gov/28689762
https://pubmed.ncbi.nlm.nih.gov/28689762
Autor:
Gordon Y. T. Liu, W. Frank Richey, Joanne E. Betso, Brian Hughes, Joanna Klapacz, Joerg Lindner
Publikováno v:
Ullmann's Encyclopedia of Industrial Chemistry. :1-25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9b30afeadc65f06068960d556d683c5
https://doi.org/10.1002/14356007.a06_565.pub2
https://doi.org/10.1002/14356007.a06_565.pub2
Autor:
Lisiane B. Meira, Leona D. Samson, Roderick T. Bronson, Joanna Klapacz, Jennifer A. Calvo, David Luchetti, Winfried Edelmann
Publikováno v:
Proceedings of the National Academy of Sciences. 106:576-581
Alkylation-induced O 6 -methylguanine ( O 6 MeG) DNA lesions can be mutagenic or cytotoxic if unrepaired by the O 6 MeG-DNA methyltransferase (Mgmt) protein. O 6 MeG pairs with T during DNA replication, and if the O 6 MeG:T mismatch persists, a G:C t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a17689ca7faea0d72cdc79b55fa1c141
https://doi.org/10.1073/pnas.0811991106
https://doi.org/10.1073/pnas.0811991106