Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Joanna Kirkpatrick"'
Reducing the metabolic burden of rRNA synthesis promotes healthy longevity in Caenorhabditis elegans
Autor:
Samim Sharifi, Prerana Chaudhari, Asya Martirosyan, Alexander Otto Eberhardt, Finja Witt, André Gollowitzer, Lisa Lange, Yvonne Woitzat, Eberechukwu Maryann Okoli, Huahui Li, Norman Rahnis, Joanna Kirkpatrick, Oliver Werz, Alessandro Ori, Andreas Koeberle, Holger Bierhoff, Maria Ermolaeva
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Ribosome biogenesis is initiated by RNA polymerase I (Pol I)-mediated synthesis of pre-ribosomal RNA (pre-rRNA). Pol I activity was previously linked to longevity, but the underlying mechanisms were not studied beyond effects on nucleolar st
Externí odkaz:
https://doaj.org/article/e8c06c7d253c4ce7a8ddf6f0c29bac62
Publikováno v:
Current Plant Biology, Vol 35, Iss , Pp 100310- (2023)
Being a preparative step for germination, seed imbibition is a hydration process that involves the release of seed molecules into the environment, an essential ecological aspect of this phase. On one side this leakage leads to unlocking the seed dorm
Externí odkaz:
https://doaj.org/article/462f864f3a584d9f9f4ec92212848011
Autor:
Radhika A Varier, Theodora Sideri, Charlotte Capitanchik, Zornitsa Manova, Enrica Calvani, Alice Rossi, Raghu R Edupuganti, Imke Ensinck, Vincent WC Chan, Harshil Patel, Joanna Kirkpatrick, Peter Faull, Ambrosius P Snijders, Michiel Vermeulen, Markus Ralser, Jernej Ule, Nicholas M Luscombe, Folkert J van Werven
Publikováno v:
eLife, Vol 11 (2022)
N6- methyladenosine (m6A) RNA modification impacts mRNA fate primarily via reader proteins, which dictate processes in development, stress, and disease. Yet little is known about m6A function in Saccharomyces cerevisiae, which occurs solely during ea
Externí odkaz:
https://doaj.org/article/1fdf12dea2744b80b90c259dff7abe55
Autor:
Murat Kirtay, Josefine Sell, Christian Marx, Holger Haselmann, Mihai Ceanga, Zhong-Wei Zhou, Vahid Rahmati, Joanna Kirkpatrick, Katrin Buder, Paulius Grigaravicius, Alessandro Ori, Christian Geis, Zhao-Qi Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Ataxia Telangiectasia and Rad3-related (ATR) is a key regulator of replication stress response; yet, mutations within the ATR gene cause human ATR-Seckel Syndrome associated with microcephaly and intellectual disability. Here, the authors show neuron
Externí odkaz:
https://doaj.org/article/2dd9c267ac854fe5bdc2ba175941b03b
Autor:
Christian Marx, Marc U. Schaarschmidt, Joanna Kirkpatrick, Lisa Marx-Blümel, Melisa Halilovic, Martin Westermann, Doerte Hoelzer, Felix B. Meyer, Yibo Geng, Katrin Buder, Hauke M. Schadwinkel, Kanstantsin Siniuk, Sabine Becker, René Thierbach, James F. Beck, Jürgen Sonnemann, Zhao-Qi Wang
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-19 (2021)
Abstract Introduction Ewing's sarcoma is an aggressive childhood malignancy whose outcome has not substantially improved over the last two decades. In this study, combination treatments of the HSP90 inhibitor AUY922 with either the ATR inhibitor VE82
Externí odkaz:
https://doaj.org/article/d8fb96d8e11f4e79b641bb5a2f9a1a6f
Autor:
Alicia Tapias, David Lázaro, Bo-Kun Yin, Seyed Mohammad Mahdi Rasa, Anna Krepelova, Erika Kelmer Sacramento, Paulius Grigaravicius, Philipp Koch, Joanna Kirkpatrick, Alessandro Ori, Francesco Neri, Zhao-Qi Wang
Publikováno v:
eLife, Vol 10 (2021)
Brain homeostasis is regulated by the viability and functionality of neurons. HAT (histone acetyltransferase) and HDAC (histone deacetylase) inhibitors have been applied to treat neurological deficits in humans; yet, the epigenetic regulation in neur
Externí odkaz:
https://doaj.org/article/33e304c7257749b2a06dea0c9d2f2260
Autor:
Maximilian Fleischmann, Mike Fischer, Ulf Schnetzke, Colin Fortner, Joanna Kirkpatrick, Florian H. Heidel, Andreas Hochhaus, Sebastian Scholl
Publikováno v:
Cells, Vol 10, Iss 11, p 2992 (2021)
OBJECTIVES: Internal tandem duplications (ITDs) of the Fms-like tyrosine kinase 3 (FLT3) represent the most frequent molecular aberrations in acute myeloid leukemia (AML) and are associated with an inferior prognosis. The pattern of downstream activa
Externí odkaz:
https://doaj.org/article/f1f3d0de94324f91b33d1ea4ce8bcb3d
Autor:
Annette Böhmer, Saskia Barz, Katjana Schwab, Ulrike Kolbe, Anke Gabel, Joanna Kirkpatrick, Oliver Ohlenschläger, Matthias Görlach, Frank-D. Böhmer
Publikováno v:
Redox Biology, Vol 28, Iss , Pp - (2020)
Oxidative modification of cysteine residues has been shown to regulate the activity of several protein-tyrosine kinases. We explored the possibility that Fms-like tyrosine kinase 3 (FLT3), a hematopoietic receptor-tyrosine kinase, is subject to this
Externí odkaz:
https://doaj.org/article/733061e6529849cea6b72e1d9892b97e
Autor:
Domenica Farci, Emma Cocco, Marta Tanas, Joanna Kirkpatrick, Andrea Maxia, Elena Tamburini, Wolfgang P. Schröder, Dario Piano
Publikováno v:
Journal of Bioenergetics and Biomembranes. 54:273-281
Salinibacter ruber is an extremophilic bacterium able to grow in high-salts environments, such as saltern crystallizer ponds. This halophilic bacterium is red-pigmented due to the production of several carotenoids and their derivatives. Two of these
Autor:
Charlotte Capitanchik, Theodora Sideri, Radhika A Varier, Zornitsa Manova, Enrica Calvani, Alice Rossi, Raghu R Edupuganti, Imke Ensinck, Vincent WC Chan, Harshil Patel, Joanna Kirkpatrick, Peter Faull, Ambrosius P Snijders, Michiel Vermeulen, Markus Ralser, Jernej Ule, Nicholas M Luscombe, Folkert J van Werven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93b8f6b26f24df6a9ff9a5422168dc7f
https://doi.org/10.7554/elife.84034.sa2
https://doi.org/10.7554/elife.84034.sa2