Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate

Autor: Joanna J. Kaylor, Tongzhou Xu, Norianne T. Ingram, Avian Tsan, Hayk Hakobyan, Gordon L. Fain, Gabriel H. Travis

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)

It is currently thought that visual pigments in vertebrate photoreceptors are regenerated exclusively through enzymatic cycles. Here the authors show that mammalian photoreceptors also regenerate opsin pigments in light through photoisomerization of

Externí odkaz: https://doaj.org/article/1627c4ab61794e10891586d484023cf9

Non-photopic and photopic visual cycles differentially regulate immediate, early and late-phases of cone photoreceptor-mediated vision

Autor: Susan E. Brockerhoff, Gabriel H. Travis, Joanna J. Kaylor, Eoghan M. McGarrigle, Diego Cobice, Dionissia A. Pepe, Breandán N. Kennedy, James B. Hurley, Rebecca Ward

Cone photoreceptors in the retina enable vision over a wide range of light intensities. However, the processes enabling cone vision in bright light (i.e. photopic vision) are not adequately understood. Chromophore regeneration of cone photopigments m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4790b98fc8ab067a4411bd208d97a57e
https://doi.org/10.1101/2020.02.15.950915

Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate

Autor: Hayk Hakobyan, Avian Tsan, Gabriel H. Travis, Norianne T. Ingram, Joanna J. Kaylor, Gordon L. Fain, Tongzhou Xu

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature communications, vol 8, iss 1
Nature Communications

The light absorbing chromophore in opsin visual pigments is the protonated Schiff base of 11-cis-retinaldehyde (11cRAL). Absorption of a photon isomerizes 11cRAL to all-trans-retinaldehyde (atRAL), briefly activating the pigment before it dissociates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d42624bc9c9d3eb5cb4a8520fd0d5ac
https://doi.org/10.1038/s41467-017-00018-4

Identification of DES1 as a Vitamin A Isomerase in Müller Glial Cells of the Retina

Autor: Joanna J. Kaylor, Shanta Sarfare, C Nathaniel Roybal, Paul Kim, Tongzhou Xu, Samer Habib, Gabriel H. Travis, Steven Nusinowitz, Jeremy D. Cook, Anita Kim, Anh Miu, Quan Yuan, Jacob Makshanoff

Publikováno v: Nature chemical biology
Nature chemical biology, vol 9, iss 1

Absorption of a light particle by an opsin-pigment causes photoisomerization of its retinaldehyde chromophore. Restoration of light sensitivity to the resulting apo-opsin requires chemical re-isomerization of the photobleached chromophore. This is ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa782a01339f755f730b12ac2f3086e6
http://europepmc.org/articles/PMC3522777

Diacylglycerol O-Acyltransferase Type-1 Synthesizes Retinyl Esters in the Retina and Retinal Pigment Epithelium

Autor: Roxana A. Radu, Jane Hu, Shannan Eddington, Marcia Lloyd, Nicholas Bischoff, Jacob Makshanoff, Gabriel H. Travis, Joanna J. Kaylor, Dean Bok, Tran Bianconi

Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 5, p e0125921 (2015)
PloS one, vol 10, iss 5
Kaylor, JJ; Radu, RA; Bischoff, N; Makshanoff, J; Hu, J; Lloyd, M; et al.(2015). Diacylglycerol O-acyltransferase type-1 synthesizes retinyl esters in the retina and retinal pigment epithelium. PLoS ONE, 10(5). doi: 10.1371/journal.pone.0125921. UCLA: Retrieved from: http://www.escholarship.org/uc/item/5zb9k8b5

© 2015 Kaylor et al. Retinyl esters represent an insoluble storage form of vitamin A and are substrates for the retinoid isomerase (Rpe65) in cells of the retinal pigment epithelium (RPE). The major retinyl-ester synthase in RPE cells is lecithin:re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956f1306b53f08c9780d85538d8b9f07
http://europepmc.org/articles/PMC4431840