Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Joanna I Sulkowska"'
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 6, p e1011959 (2024)
Unlike proteins, RNAs deposited in the Protein Data Bank do not contain topological knots. Recently, admittedly, the first trefoil knot and some lasso-type conformations have been found in experimental RNA structures, but these are still exceptional
Externí odkaz:
https://doaj.org/article/cb68e53914cf4cf5a231d36d5e1e50f3
Autor:
Agata P Perlinska, Adam Stasiulewicz, Mai Lan Nguyen, Karolina Swiderska, Mikolaj Zmudzinski, Alicja W Maksymiuk, Marcin Drag, Joanna I Sulkowska
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 11, p e1010667 (2022)
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused both a health and economic crisis around the world. Its papain-like protease (PLpro) is one of the protein targets utilized in designing new drugs that would aid vaccin
Externí odkaz:
https://doaj.org/article/a93dbfcd30ab48748e464f2830d40c68
Autor:
Vasilina Zayats, Agata P Perlinska, Aleksandra I Jarmolinska, Borys Jastrzebski, Stanislaw Dunin-Horkawicz, Joanna I Sulkowska
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 10, p e1009502 (2021)
While the slipknot topology in proteins has been known for over a decade, its evolutionary origin is still a mystery. We have identified a previously overlooked slipknot motif in a family of two-domain membrane transporters. Moreover, we found that t
Externí odkaz:
https://doaj.org/article/f105ce84f84c4826ad5083eca7f3d2ec
Autor:
Agata P Perlinska, Adam Stasiulewicz, Ewa K Nawrocka, Krzysztof Kazimierczuk, Piotr Setny, Joanna I Sulkowska
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 5, p e1007904 (2020)
S-adenosylmethionine (SAM) is one of the most important enzyme substrates. It is vital for the function of various proteins, including large group of methyltransferases (MTs). Intriguingly, some bacterial and eukaryotic MTs, while catalysing the same
Externí odkaz:
https://doaj.org/article/f916fc81e7da453dbc8434d42df8ea53
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 3, p e1005970 (2018)
The folding of proteins with a complex knot is still an unresolved question. Based on representative members of Ubiquitin C-terminal Hydrolases (UCHs) that contain the 52 knot in the native state, we explain how UCHs are able to unfold and refold in
Externí odkaz:
https://doaj.org/article/4ec51659141f42f0ade890c2cfb4b0c2
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176744 (2017)
Molecular dynamics simulations are used to explore the effects of chaperonin-like cages on knotted proteins with very low sequence similarity, different depths of a knot but with a similar fold, and the same type of topology. The investigated protein
Externí odkaz:
https://doaj.org/article/10e3c2f5b5684e1ba63d4730e6320a90
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0165986 (2016)
We analysed the structure of deeply knotted proteins representing three unrelated families of knotted proteins. We looked at the correlation between positions of knotted cores in these proteins and such local structural characteristics as the number
Externí odkaz:
https://doaj.org/article/32aead7c514c42668cb2df4b78e202b7
Autor:
Ellinor Haglund, Joanna I Sulkowska, Jeffrey K Noel, Heiko Lammert, José N Onuchic, Patricia A Jennings
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 6, p e1003613 (2014)
A four-helix bundle is a well-characterized motif often used as a target for designed pharmaceutical therapeutics and nutritional supplements. Recently, we discovered a new structural complexity within this motif created by a disulphide bridge in the
Externí odkaz:
https://doaj.org/article/0b1317bdbf2b483687a4e26c0b16044b
Autor:
Adam Stasiulewicz, Anna Lesniak, Magdalena Bujalska-Zadrożny, Tomasz Pawiński, Joanna I. Sulkowska
Publikováno v:
Journal of Chemical Information and Modeling. 63:1012-1027
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::401a8ecc5a0bf7ae4731dd8f910f5143
https://doi.org/10.1021/acs.jcim.2c01503
https://doi.org/10.1021/acs.jcim.2c01503
Autor:
Adam Stasiulewicz, Anna Lesniak, Piotr Setny, Magdalena Bujalska-Zadrożny, Joanna I. Sulkowska
Publikováno v:
ACS Chemical Neuroscience. 13:2991-3007
Cannabinoid receptor type 1 (CB1) is an important modulator of many key physiological functions and thus a compelling molecular target. However, safe CB1 targeting is a non-trivial task. In recent years, there has been a surge of data indicating that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35eb558d77bbd8bddcf1a59c848ac20
https://doi.org/10.1021/acschemneuro.2c00502
https://doi.org/10.1021/acschemneuro.2c00502