Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Joanna I, Sulkowska"'
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 6, p e1011959 (2024)
Unlike proteins, RNAs deposited in the Protein Data Bank do not contain topological knots. Recently, admittedly, the first trefoil knot and some lasso-type conformations have been found in experimental RNA structures, but these are still exceptional
Externí odkaz:
https://doaj.org/article/cb68e53914cf4cf5a231d36d5e1e50f3
Autor:
Agata P. Perlinska, Mai Lan Nguyen, Smita P. Pilla, Emilia Staszor, Iwona Lewandowska, Agata Bernat, Elżbieta Purta, Rafal Augustyniak, Janusz M. Bujnicki, Joanna I. Sulkowska
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2024)
We have been aware of the existence of knotted proteins for over 30 years—but it is hard to predict what is the most complicated knot that can be formed in proteins. Here, we show new and the most complex knotted topologies recorded to date—doubl
Externí odkaz:
https://doaj.org/article/00796d098d6c4af09d78c454d2c03937
Autor:
Mateusz Jedrzejewski, Barbara Belza, Iwona Lewandowska, Marta Sadlej, Agata P. Perlinska, Rafal Augustyniak, Thomas Christian, Ya-Ming Hou, Marcin Kalek, Joanna I. Sulkowska
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 3999-4008 (2023)
The Nep1 protein is essential for the formation of eukaryotic and archaeal small ribosomal subunits, and it catalyzes the site-directed SAM-dependent methylation of pseudouridine (Ψ) during pre-rRNA processing. It possesses a non–trivial topology,
Externí odkaz:
https://doaj.org/article/fce9cd31689d48fc924328112827005f
Autor:
Agata P Perlinska, Adam Stasiulewicz, Mai Lan Nguyen, Karolina Swiderska, Mikolaj Zmudzinski, Alicja W Maksymiuk, Marcin Drag, Joanna I Sulkowska
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 11, p e1010667 (2022)
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused both a health and economic crisis around the world. Its papain-like protease (PLpro) is one of the protein targets utilized in designing new drugs that would aid vaccin
Externí odkaz:
https://doaj.org/article/a93dbfcd30ab48748e464f2830d40c68
Autor:
Vasilina Zayats, Agata P Perlinska, Aleksandra I Jarmolinska, Borys Jastrzebski, Stanislaw Dunin-Horkawicz, Joanna I Sulkowska
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 10, p e1009502 (2021)
While the slipknot topology in proteins has been known for over a decade, its evolutionary origin is still a mystery. We have identified a previously overlooked slipknot motif in a family of two-domain membrane transporters. Moreover, we found that t
Externí odkaz:
https://doaj.org/article/f105ce84f84c4826ad5083eca7f3d2ec
Autor:
Adam Stasiulewicz, Anna Lesniak, Magdalena Bujalska-Zadrożny, Tomasz Pawiński, Joanna I. Sulkowska
Publikováno v:
Journal of Chemical Information and Modeling. 63:1012-1027
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::401a8ecc5a0bf7ae4731dd8f910f5143
https://doi.org/10.1021/acs.jcim.2c01503
https://doi.org/10.1021/acs.jcim.2c01503
Autor:
Agata P Perlinska, Adam Stasiulewicz, Ewa K Nawrocka, Krzysztof Kazimierczuk, Piotr Setny, Joanna I Sulkowska
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 5, p e1007904 (2020)
S-adenosylmethionine (SAM) is one of the most important enzyme substrates. It is vital for the function of various proteins, including large group of methyltransferases (MTs). Intriguingly, some bacterial and eukaryotic MTs, while catalysing the same
Externí odkaz:
https://doaj.org/article/f916fc81e7da453dbc8434d42df8ea53
Autor:
Adam Stasiulewicz, Anna Lesniak, Piotr Setny, Magdalena Bujalska-Zadrożny, Joanna I. Sulkowska
Publikováno v:
ACS Chemical Neuroscience. 13:2991-3007
Cannabinoid receptor type 1 (CB1) is an important modulator of many key physiological functions and thus a compelling molecular target. However, safe CB1 targeting is a non-trivial task. In recent years, there has been a surge of data indicating that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35eb558d77bbd8bddcf1a59c848ac20
https://doi.org/10.1021/acschemneuro.2c00502
https://doi.org/10.1021/acschemneuro.2c00502
Autor:
Agata P. Perlinska, Wanda H. Niemyska, Bartosz A. Gren, Marek Bukowicki, Szymon Nowakowski, Pawel Rubach, Joanna I. Sulkowska
Publikováno v:
Protein Science. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15f4a3d275587c112eaa6b8807c76c23
https://doi.org/10.1002/pro.4631
https://doi.org/10.1002/pro.4631
Autor:
Mateusz Jedrzejewski, Barbara Bełza, Iwona Lewandowska, Marta Sadlej, Agata P. Perlinska, Rafal Augustyniak, Thomas Christian, Ya–Ming Hou, Marcin Kalek, Joanna I. Sulkowska
Nep1 is a protein essential for the formation of the eukaryotic and archaeal small ribosomal subunit. It is an enzyme responsible for the site–specific SAM–dependent methylation of pseudouridine (Ψ) during the pre–rRNA processing. It possesses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cb073b8947141a7919c8efbb36f3765
https://doi.org/10.1101/2023.03.21.532383
https://doi.org/10.1101/2023.03.21.532383
