Výsledky vyhledávání - "Joanna Hinton"

Novel nonpeptide CCK-B antagonists: design and development of quinazolinone derivatives as potent, selective, and orally active CCK-B antagonists

Autor: Janak Khimchand Padia, Bruce David Roth, N. Suman-Chauhan, Julius Pablo, Bharat Kalidas Trivedi, Lakhbir Singh, Mark J. Field, Ken Meecham, Louise Webdale, Rob D. Pinnock, Joanna Hinton

Publikováno v: Journal of medicinal chemistry. 41(7)

We have designed a novel series of CCK-B receptor antagonists by combining key pharmacophores, an arylurea moiety of 1 and a quinazolinone ring of 3, from two known series. Our earlier studies showed that compounds with methylene linkers in our "targ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33643346b163cd6cef61b61166c5960c
https://pubmed.ncbi.nlm.nih.gov/9544204

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Effect of CI-988 on cholecystokinin tetrapeptide-induced panic symptoms in healthy volunteers

Autor: Phillip A. Reece, Joanna Hinton, Diana Koszycki, Michel Paradis, Jacques Bradwejn, Allen J. Sedman

Publikováno v: Biological psychiatry. 38(11)

A randomized, placebo-controlled, double-blind, three-way crossover design was used to evaluate the effectiveness of single oral 100 mg doses of CI-988, a cholecystokinin B (CCKB) antagonist, in attenuating panic symptoms induced by intravenous injec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::873e66a5c09d9debbdaed553713d284c
https://pubmed.ncbi.nlm.nih.gov/8580227

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