Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Joanna Gemel"'
Publikováno v:
Journal of Clinical and Translational Science, Vol 6, Pp 84-85 (2022)
OBJECTIVES/GOALS: We have shown that small extracellular vesicles (exosomes) isolated from patients with a history of ACS disrupt the endothelium in vitro. Sequencing of miRNA contents of these vesicles suggested that miR let-7c was differentially ex
Externí odkaz:
https://doaj.org/article/75fce130708d469987076fab2a707a18
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Endothelial damage is central to the pathogenesis of many of the complications of sickle cell disease. Circulating extracellular vesicles (EVs) have been implicated in modulating endothelial behavior in a variety of different, diseases with vascular
Externí odkaz:
https://doaj.org/article/0568afc5e87745379e073aaad6e75d26
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 8884 (2020)
Intercellular junctions maintain the integrity of the endothelium. We previously found that the adherens and tight junctions between endothelial cells are disrupted by plasma extracellular vesicles from patients with sickle cell disease (especially t
Externí odkaz:
https://doaj.org/article/ba37f70a253f471d9487cf19fd85b2e2
Publikováno v:
Blood. 140:8243-8244
Autor:
Margaret Harrington, Yifan Mao, Gabrielle Lapping-Carr, Joanna Gemel, Radhika Peddinti, Eric C. Beyer, Gianna Sparks
Publikováno v:
Pediatric research
Background Small cell-derived extracellular vesicles (EVs) can affect endothelial function. We previously found that patients with sickle cell disease (SCD) have greater numbers of circulating EVs than subjects without the disease, and the EVs differ
Publikováno v:
Journal of Clinical Medicine; Volume 11; Issue 3; Pages: 816
Journal of Clinical Medicine, Vol 11, Iss 816, p 816 (2022)
Journal of Clinical Medicine, Vol 11, Iss 816, p 816 (2022)
We previously found that the plasma of patients with sickle cell disease (SCD) contains large numbers of small extracellular vesicles (EVs) and that the EVs disrupt the integrity of endothelial cell monolayers (especially if obtained during episodes
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 8884, p 8884 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 23
International Journal of Molecular Sciences
Volume 21
Issue 23
Intercellular junctions maintain the integrity of the endothelium. We previously found that the adherens and tight junctions between endothelial cells are disrupted by plasma extracellular vesicles from patients with sickle cell disease (especially t
Autor:
Rangarajan D. Nadadur, Jiajie Yan, Brigitte Laforest, Christopher R. Weber, Wenli Dai, Eric C. Beyer, Kaitlyn M Shen, Xun Ai, Ye Li, Margaret Gadek, Michael Broman, Heather L. Smith, Edward G. Lakata, Jaclyn A. Brennan, Ivan P. Moskowitz, Igor R. Efimov, Bruce D. Ziman, Mingyi Wang, Narayanan Kasthuri, Le Shen, Joanna Gemel, Jing Zhang
Publikováno v:
Circ Res
Rationale: ZO-1 (Zona occludens 1), encoded by the tight junction protein 1 ( TJP1 ) gene, is a regulator of paracellular permeability in epithelia and endothelia. ZO-1 interacts with the actin cytoskeleton, gap, and adherens junction proteins and lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3d31e3f9267db11533496cca7731a2
https://europepmc.org/articles/PMC7334106/
https://europepmc.org/articles/PMC7334106/
Publikováno v:
Cancers
Volume 11
Issue 4
Cancers, Vol 11, Iss 4, p 476 (2019)
Volume 11
Issue 4
Cancers, Vol 11, Iss 4, p 476 (2019)
Intercellular communication is accomplished by passage of ions and small molecules through gap junction channels in directly contacting cells or by secretion and response to transmitters, hormones and extracellular vesicles in cells that are distant
Autor:
Yifan Mao, Joanna Gemel, Radhika Peddinti, Eric C. Beyer, Gianna Sparks, Margaret Harrington, Gabrielle Lapping-Carr
Publikováno v:
Pediatr Res