Zobrazeno 1 - 10
of 261
pro vyhledávání: '"Joanna Floros"'
Autor:
David S. Phelps, Vernon M. Chinchilli, Lili Yang, Debra Shearer, Judith Weisz, Xuesheng Zhang, Joanna Floros
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Using the Toponome Imaging System (TIS), a serial immunostainer, we studied the patterns of expression of multiple markers in alveolar macrophages (AM) from female mice lacking surfactant protein A (SP-A knockouts; KO) after “rescue” wit
Externí odkaz:
https://doaj.org/article/8ac9b45f5778426ca016c14cc88de810
Autor:
Shaili Amatya, Meixia Ye, Lili Yang, Chintan K. Gandhi, Rongling Wu, Beth Nagourney, Joanna Floros
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/1a3232cde8394c349d9794bab67036b7
Autor:
Nithyananda Thorenoor, Joanna Floros
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Human surfactant protein (SP)-A1 and SP-A2 exhibit differential qualitative and quantitative effects on the alveolar macrophage (AM), including a differential impact on the AM miRNome. Moreover, SP-A rescue (treatment) of SP-A-knockout (KO) infected
Externí odkaz:
https://doaj.org/article/766e94688a7b46babdfdc6805519e2c0
Autor:
Lynnlee C. Depicolzuane, Catherine M. Roberts, Neal J. Thomas, Keenan Anderson-Fears, Dajiang Liu, João Paulo Pereira Barbosa, Felipe Rodrigues Souza, André Silva Pimentel, Joanna Floros, Chintan K. Gandhi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection-related hospitalization in the first year of life. Surfactant dysfunction is central to pathophysiologic mechanisms of various pulmonary diseases including RS
Externí odkaz:
https://doaj.org/article/e75f1a13abeb4118a92f025e81145995
Autor:
Ata Abbasi, Chixiang Chen, Chintan K. Gandhi, Rongling Wu, Annie Pardo, Moises Selman, Joanna Floros
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Surfactant proteins (SPs) are important for normal lung function and innate immunity of the lungs and their genes have been identified with significant genetic variability. Changes in quantity or quality of SPs due to genetic mutations or natural gen
Externí odkaz:
https://doaj.org/article/9dcf358bef7f4d86a479f974c4dff9e4
Autor:
David S. Phelps, Vernon M. Chinchilli, Xuesheng Zhang, Debra Shearer, Judith Weisz, Joanna Floros
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundSurfactant protein-A (SP-A) plays a critical role in lung innate immunity by regulating alveolar macrophages (AM), expression of inflammatory mediators, and other host defense proteins. The toponome imaging system (TIS), a serial immunostai
Externí odkaz:
https://doaj.org/article/68134793cb7844ec8a9cc14fc6545e1d
Autor:
Chintan K. Gandhi, Neal J. Thomas, Ye Meixia, Debbie Spear, Chenqi Fu, Shouhao Zhou, Rongling Wu, Garrett Keim, Nadir Yehya, Joanna Floros
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
We studied associations of persistent respiratory morbidity (PRM) at 6 and 12 months after acute respiratory failure (ARF) in previously healthy children with single-nucleotide polymorphisms (SNPs) of surfactant protein (SP) genes. Of the 250 enrolle
Externí odkaz:
https://doaj.org/article/7d8a3a6955584acab6a4f9de4e9c15d9
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2022)
Pulmonary surfactant proteins have many roles in surfactant- related functions and innate immunity. One of these proteins is the surfactant protein A (SP-A) that plays a role in both surfactant-related processes and host defense and is the focus in t
Externí odkaz:
https://doaj.org/article/dfa19340ac7f4be4905cc8e4ebc7664a
Autor:
David S. Phelps, Vernon M. Chinchilli, Judith Weisz, Debra Shearer, Xuesheng Zhang, Joanna Floros
Publikováno v:
Biomarker Research, Vol 8, Iss 1, Pp 1-20 (2020)
Abstract Background We used the Toponome Imaging System (TIS) to identify “patterns of marker expression”, referred to here as combinatorial molecular phenotypes (CMPs) in alveolar macrophages (AM) in response to the innate immune molecule, SP-A1
Externí odkaz:
https://doaj.org/article/5fce687e82db4d42a2273d37203fae46
Autor:
Joanna Floros, Nikolaos Tsotakos
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The human SFTPA1 and SFTPA2 genes encode the surfactant protein A1 (SP-A1) and SP-A2, respectively, and they have been identified with significant genetic and epigenetic variability including sequence, deletion/insertions, and splice variants. The su
Externí odkaz:
https://doaj.org/article/e499d5a68cca4cb0a150658f6eafc286