Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Joanna Fedorowicz"'
Autor:
Joanna Fedorowicz, Jarosław Sączewski
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4649 (2024)
This review provides a comprehensive overview of recent advancements in the design and synthesis of biologically active quaternary ammonium compounds (QACs). The covered scope extends beyond commonly reviewed antimicrobial derivatives to include synt
Externí odkaz:
https://doaj.org/article/f84b1426401e4df786503076ea44327a
Autor:
Joanna Fedorowicz, Dagmara Bazar, Wioletta Brankiewicz, Hanna Kapica, Krzesimir Ciura, Beata Zalewska-Piątek, Rafał Piątek, Krzysztof Cal, Krystyna Mojsiewicz-Pieńkowska, Jarosław Sączewski
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Low-molecular synthetic fluorophores are convenient tools in bioimaging applications. Several derivatives of Safirinium dyes as well as their reactive N-hydroxysuccinimide (NHS) esters bearing diverse substituents were synthesized and evalua
Externí odkaz:
https://doaj.org/article/88b3e4bc78774a79b3501871801084a6
Autor:
Anita Kornicka, Karol Gzella, Katarzyna Garbacz, Małgorzata Jarosiewicz, Maria Gdaniec, Joanna Fedorowicz, Łukasz Balewski, Jakub Kokoszka, Anna Ordyszewska
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 918 (2023)
A series of 2-(1H-indol-2-yl)-3-acrylonitrile derivatives, 2a–x, 3, 4a–b, 5a–d, 6a–b, and 7, were synthesized as potential antitumor and antimicrobial agents. The structures of the prepared compounds were evaluated based on elemental analysis
Externí odkaz:
https://doaj.org/article/4da83220e36b4c48b94d5a89eed361e6
Autor:
Łukasz Balewski, Jakub Kokoszka, Joanna Fedorowicz, Polina Ilina, Päivi Tammela, Maria Gdaniec, Anita Kornicka
Publikováno v:
Medical Sciences Forum, Vol 14, Iss 1, p 58 (2022)
As a continuation of our previous investigations aimed at the synthesis of novel nitrogen-containing heterocycles and their metal complexes, we have now prepared two series of compounds incorporating a phthalazine ring at the position C2 of 4,5-dihyd
Externí odkaz:
https://doaj.org/article/698c4e8867234e74b88d876398a9f3af
Publikováno v:
Molbank, Vol 2019, Iss 4, p M1093 (2019)
The title compound, 2,2’-[(1,4-dimethoxy-1,4-dioxobutane-2,3-diylidene)bis(azanylylidene)]bis(quinoline-3-carboxylic acid) was synthesized from isoxazolo[3,4-b]quinolin-3(1H)-one and dimethyl acetylenedicarboxylate (DMAD) via a double aza-Michael a
Externí odkaz:
https://doaj.org/article/5bbe549b232640038c1af72e862c2290
Publikováno v:
Applied Sciences, Vol 11, Iss 12, p 5498 (2021)
Isoxazolo[3,4-b]pyridin-3(1H)-ones are ‘spring-loaded’ compounds that quantitatively react with iminium salts derived from formaldehyde and secondary amines to yield fluorescent Safirinium dyes. The mechanism and energetics of the above tandem Ma
Externí odkaz:
https://doaj.org/article/51398cbc02fd4493896d7e74bcc3f818
Autor:
Joanna Fedorowicz, Magdalena Wierzbicka, Marek Cebrat, Paulina Wiśniewska, Rafał Piątek, Beata Zalewska-Piątek, Zbigniew Szewczuk, Jarosław Sączewski
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 24, p 9643 (2020)
Mass spectrometry methods are commonly used in the identification of peptides and biomarkers. Due to a relatively low abundance of proteins in biological samples, there is a need for the development of novel derivatization methods that would improve
Externí odkaz:
https://doaj.org/article/72d9147a6eb443d88dc589a83814b7a8
Autor:
Krzesimir Ciura, Joanna Fedorowicz, Petar Žuvela, Mario Lovrić, Hanna Kapica, Paweł Baranowski, Wiesław Sawicki, Ming Wah Wong, Jarosław Sączewski
Publikováno v:
Molecules, Vol 25, Iss 20, p 4835 (2020)
Currently, rapid evaluation of the physicochemical parameters of drug candidates, such as lipophilicity, is in high demand owing to it enabling the approximation of the processes of absorption, distribution, metabolism, and elimination. Although the
Externí odkaz:
https://doaj.org/article/fe9601ce57504dbb9e82b9008fde9bc9
Autor:
Krzesimir Ciura, Joanna Fedorowicz, Filip Andrić, Katarzyna Ewa Greber, Alina Gurgielewicz, Wiesław Sawicki, Jarosław Sączewski
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 21, p 5288 (2019)
Lipophilicity is a vital physicochemical parameter of a molecule, which affects several biological processes such as absorption, tissue distribution, and pharmacokinetic properties. In this study, evaluation of lipophilicities of a series of novel fl
Externí odkaz:
https://doaj.org/article/e3bbd9debff94ac8afdc48ab1acbfad6
Autor:
Ordyszewska, Anita Kornicka, Karol Gzella, Katarzyna Garbacz, Małgorzata Jarosiewicz, Maria Gdaniec, Joanna Fedorowicz, Łukasz Balewski, Jakub Kokoszka, Anna
Publikováno v:
Pharmaceuticals; Volume 16; Issue 7; Pages: 918
A series of 2-(1H-indol-2-yl)-3-acrylonitrile derivatives, 2a–x, 3, 4a–b, 5a–d, 6a–b, and 7, were synthesized as potential antitumor and antimicrobial agents. The structures of the prepared compounds were evaluated based on elemental analysis