Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Joanna F. McGouran"'
Autor:
Ellen M. Fay, Joanna F. McGouran
Publikováno v:
Results in Chemistry, Vol 5, Iss , Pp 100939- (2023)
The DNA damage repair enzyme SNM1A is a potential target for anti-cancer chemotherapy. SNM1A has a metal-containing active site that has previously been successfully targeted with nucleosides/oligonucleotides modified with metal–binding groups. Nuc
Externí odkaz:
https://doaj.org/article/2498549f748443508b5efd4b80541835
Autor:
Neil C. Taylor, Joanna F. McGouran
Publikováno v:
Frontiers in Chemistry, Vol 7 (2020)
The regulation of ubiquitination status in the cell is controlled by ubiquitin ligases acting in tandem with deubiquitinating enzymes. Ubiquitination controls many key processes in the cell from division to death making its tight regulation key to op
Externí odkaz:
https://doaj.org/article/6d62b1d918f44ba4bb07360d45c78f37
Autor:
Eva-Maria Dürr, Joanna F. McGouran
Publikováno v:
Molecules, Vol 26, Iss 2, p 320 (2021)
SNM1A is a nuclease that is implicated in DNA interstrand crosslink repair and, as such, its inhibition is of interest for overcoming resistance to chemotherapeutic crosslinking agents. However, the number and identity of the metal ion(s) in the acti
Externí odkaz:
https://doaj.org/article/5241643fdb134e38bc85fe821f66f33d
Publikováno v:
ACS Chemical Biology
Over the past two decades, activity-based probes have enabled a range of discoveries, including the characterization of new enzymes and drug targets. However, their suitability in some labeling experiments can be limited by nonspecific reactivity, po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5f147067d28c7fa333076982f2bbe9e
http://europepmc.org/articles/PMC8689647
http://europepmc.org/articles/PMC8689647
Publikováno v:
ChemMedChem. 17
Certain cancers exhibit upregulation of DNA interstrand crosslink repair pathways, which contributes to resistance to crosslinking chemotherapy drugs and poor prognoses. Inhibition of enzymes implicated in interstrand crosslink repair is therefore a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eddb640895de2ab5c570f2ee9a676906
https://doi.org/10.1002/cmdc.202100603
https://doi.org/10.1002/cmdc.202100603
Publikováno v:
Chemical Science
Deubiquitinating enzymes (DUBs) are known to have numerous important interactions with the ubiquitin cascade and their dysregulation is associated with several diseases, including cancer and neurodegeneration. They are an important class of enzyme, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da75694435d22847c9c36a0a3242a88
https://pubmed.ncbi.nlm.nih.gov/34122797
https://pubmed.ncbi.nlm.nih.gov/34122797
Autor:
Neil C Taylor, Joanna F. McGouran
Publikováno v:
Organicbiomolecular chemistry. 19(10)
Eosin Y was assessed for its ability to induce a thiol–ene dependent protein–protein reaction in a metal-free, oxygen-tolerant, visible light mediated system. Protein–protein coupling efficiency under these mild conditions was comparable to pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944d605ed406bdadf131ee8026ea532a
https://pubmed.ncbi.nlm.nih.gov/33630007
https://pubmed.ncbi.nlm.nih.gov/33630007
Autor:
Joanna F. McGouran, Eva-Maria Dürr
Publikováno v:
Molecules, Vol 26, Iss 320, p 320 (2021)
Molecules
Volume 26
Issue 2
Molecules
Volume 26
Issue 2
SNM1A is a nuclease that is implicated in DNA interstrand crosslink repair and, as such, its inhibition is of interest for overcoming resistance to chemotherapeutic crosslinking agents. However, the number and identity of the metal ion(s) in the acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1727c4ebeda68b3f7811cf02b49faee
https://www.mdpi.com/1420-3049/26/2/320
https://www.mdpi.com/1420-3049/26/2/320
Autor:
Joanna F. McGouran, Mark Berney
Publikováno v:
Nature Reviews Chemistry. 2:332-348
Methylation of cytosine at the 5-position is a common epigenetic modification in mammalian DNA and plays an important role in regulating gene expression. Oxidized derivatives of 5-methylcytosine were discovered recently, and some of these oxidized de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f52c8ef52dae73a01beed5eab24b8b72
https://doi.org/10.1038/s41570-018-0044-4
https://doi.org/10.1038/s41570-018-0044-4
Autor:
Eva-Maria Dürr, Joanna F. McGouran, William Doherty, Mark Berney, Manav T Manoj, Werner Theodor Jauslin
Publikováno v:
Bioorganic & Medicinal Chemistry
Graphical abstract
SNM1A is a zinc-dependent nuclease involved in the removal of interstrand crosslink lesions from DNA. Inhibition of interstrand crosslink repair enzymes such as SNM1A is a promising strategy for improving the efficacy of cross
SNM1A is a zinc-dependent nuclease involved in the removal of interstrand crosslink lesions from DNA. Inhibition of interstrand crosslink repair enzymes such as SNM1A is a promising strategy for improving the efficacy of cross
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3ae6c9cf80859c7c4e1e9fb75d1503
https://doi.org/10.1016/j.bmc.2021.116369
https://doi.org/10.1016/j.bmc.2021.116369