Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Joanna F. Flatt"'
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The bone marrow produces billions of reticulocytes daily. These reticulocytes mature into red blood cells by reducing their plasma membrane by 20% and ejecting or degrading residual internal organelles, membranes and proteins not required by the matu
Externí odkaz:
https://doaj.org/article/31c5f2486af54a7ebce2dccbe16039cf
Autor:
Joanna F. Flatt, Christian J. Stevens-Hernandez, Nicola M. Cogan, Daniel J. Eggleston, Nicole M. Haines, Kate J. Heesom, Veronique Picard, Caroline Thomas, Lesley J. Bruce
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Southeast Asian Ovalocytosis results from a heterozygous deletion of 9 amino acids in the erythrocyte anion exchange protein AE1 (band 3). The report of the first successful birth of an individual homozygous for this mutation showed an association wi
Externí odkaz:
https://doaj.org/article/61e5e7b7869d4078a752b2031b4c052b
The Molecular Basis for Altered Cation Permeability in Hereditary Stomatocytic Human Red Blood Cells
Autor:
Joanna F. Flatt, Lesley J. Bruce
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Normal human RBCs have a very low basal permeability (leak) to cations, which is continuously corrected by the Na,K-ATPase. The leak is temperature-dependent, and this temperature dependence has been evaluated in the presence of inhibitors to exclude
Externí odkaz:
https://doaj.org/article/dc3c6e7c564a465b872ea7c91f541619
Autor:
Emile van den Akker, Timothy J. Satchwell, Stephanie Pellegrin, Joanna F. Flatt, Michel Maigre, Geoff Daniels, Jean Delaunay, Lesley J. Bruce, Ashley M. Toye
Publikováno v:
Haematologica, Vol 95, Iss 8 (2010)
Background Protein 4.2 deficiency caused by mutations in the EPB42 gene results in hereditary spherocytosis with characteristic alterations of CD47, CD44 and RhAG. We decided to investigate at which stage of erythropoiesis these hallmarks of protein
Externí odkaz:
https://doaj.org/article/e6cb6d91cc184560878bfad16c55d634
Autor:
Joanna F. Flatt, Lesley J. Bruce
Publikováno v:
Haematologica, Vol 94, Iss 8 (2009)
Externí odkaz:
https://doaj.org/article/087dd46ac6854544b3ac60a437775e58
Autor:
Lesley J. Bruce, Margaret McAndrew, Helen V New, Amy Frary, William J. Astle, Rekha Anand, Joanna F. Flatt, Christian J Stevens-Hernandez, Rebecca Cardigan, Athinoula Meli, Luca Stefanucci, Karola Rehnström, Alexandra Griffiths
Publikováno v:
Transfusion. 61:2439-2449
BACKGROUND Familial pseudohyperkalemia (FP) is characterized by an increased rate of potassium leakage in refrigerated red cells and is associated with the minor allele of the single nucleotide polymorphism rs148211042 (R723Q) in the ABCB6 gene. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097388698db6c0f5baaee7f47c33b7d2
https://doi.org/10.1111/trf.16440
https://doi.org/10.1111/trf.16440
Autor:
Jonathan P. Wallis, Joanna F. Flatt, Helen V New, Catherine E. Chapman, Augusto Rendon, Waleed M. Bawazir, Michael Wiltshire, Lizanne Page, Gordon W. Stewart, Rebecca Cardigan, Lesley J. Bruce
Publikováno v:
Transfusion. 54:3043-3050
Background Familial pseudohyperkalemia (FP) is a dominantly inherited condition in which red blood cells (RBCs) have an increased cold-induced permeability to monovalent cations. Potassium leaks into the supernatant of all stored blood with time, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f026cc4cc7c0c7debbdfea8b2d3fa64
https://doi.org/10.1111/trf.12757
https://doi.org/10.1111/trf.12757
Autor:
Leo, Kager, Lesley J, Bruce, Petra, Zeitlhofer, Joanna F, Flatt, Tabita M, Maia, M Leticia, Ribeiro, Bernhard, Fahrner, Gerhard, Fritsch, Kaan, Boztug, Oskar A, Haas
Publikováno v:
Pediatric bloodcancer. 64(3)
We describe the second patient with anionic exchanger 1/band 3 null phenotype (band 3 null
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a1130c3351ed2ee108359cf090431d55
https://pubmed.ncbi.nlm.nih.gov/27718309
https://pubmed.ncbi.nlm.nih.gov/27718309
Autor:
Joanna F. Flatt, Mehul T. Dattani, Caroline Oren, Benjamin Jacobs, Gordon W. Stewart, Stephanie Grunewald, Evelien Gevers, Waleed M. Bawazir, Ai Leen Ang, Lesley J. Bruce
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 97:E987-E993
GLUT1 (glucose transporter 1) deficiency syndrome is a well-known presentation in pediatric practice. Very rare mutations not only disable carbohydrate transport but also cause the red cell membrane to be constitutively permeant to monovalent cations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2c121d1a176b83fd525ef5713fb4b0
https://doi.org/10.1210/jc.2012-1399
https://doi.org/10.1210/jc.2012-1399
Autor:
David J. Anstee, Afifah Hassan, Nicole Thornton, Rosalind Mathlouthi, Joanna F. Flatt, L Bruce, Rozi Hanisa Musa, Nurul M. Yahya, Norhanim Asidin, Yasmin Ayob
Publikováno v:
British Journal of Haematology. 158:262-273
Red cells with the D-- phenotype do not express the RHCE protein because of mutations in both alleles of the RHCE gene. At present, little is known of the effect this has on the normal function of erythrocytes. In this study a group of five families
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb699805849b2c6c6d95880f3a6ea352
https://doi.org/10.1111/j.1365-2141.2012.09149.x
https://doi.org/10.1111/j.1365-2141.2012.09149.x