Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Joanna E Brewer"'
Autor:
Alan D. Bennett, Barbara Tavano, Sara Brett, Manoj Saini, Adriano Quattrini, David J. Figueroa, Katherine L Crossland, Terri V Cornforth, Cedrik M. Britten, Joanna E. Brewer, Caitriona O'Connor, Jonathan D. Silk, Dylan Steiner, Alistair G Rust, Andrew B. Gerry, Ryan Wong, Katherine Adams, Joseph P. Sanderson, Annette Pachnio, Carlos E Peredo, Preetha Viswanathan, Junping Jing, Rachel J. M. Abbott, Guy E. Wiedermann, Laura L. Quinn, Lea Patasic, Bent K. Jakobsen
Publikováno v:
The Journal of Immunology. 208:169-180
Adoptive T cell therapy with T cells expressing affinity-enhanced TCRs has shown promising results in phase 1/2 clinical trials for solid and hematological tumors. However, depth and durability of responses to adoptive T cell therapy can suffer from
Autor:
Emma Gostick, David Price, Rebecca Ashfield, Joanna E. Brewer, Marco A. Purbhoo, Brendan J. Classon, Bruno Laugel, Bent K. Jakobsen, Brian Cameron, Deborah H. Sutton, Anita Milicic, Yi Li, Andrew K. Sewell, Ruth Moysey, Emma Baston, Nathaniel Liddy, Giovanna Bossi, Alan D. Bennett
Publikováno v:
Molecular Cancer Therapeutics. 6:2081-2091
Tumor-associated human telomerase reverse transcriptase (hTERT) is expressed in >85% of human tumors but not in most normal cells. As a result, this antigen has received considerable attention from those interested in cancer immunotherapy. Specifical
Autor:
Laszlo Radvanyi, Achim A. Jungbluth, Stanley R Frankel, Adrian Bot, Zelig Eshhar, Yoav Peretz, Kai W. Wucherpfennig, Paul F Robbins, Emma Hickman, Carlos A. Ramos, Richard A. Morgan, Joanna E Brewer
Publikováno v:
Journal for Immunotherapy of Cancer
Investigators from academia and industry gathered on August 14, 2014, in Boston at the Inaugural ImVacS conference entitled “Target Discovery for T Cell Therapy: Next Step to Advance Immunotherapies”. Novel targets, discovery strategies and enabl
Autor:
Carl H. June, Edward A. Stadtmauer, Sunita Philip, Nicholas J. Pumphrey, Saul Yanovich, Tom Holdich, Bent K. Jakobsen, Lilliam Ribeiro, Alan D. Bennett, Helen K. Tayton-Martin, Joanna E. Brewer, Andrew B. Gerry, Dan T. Vogl, Irina Kulikovskaya, Luca Melchiori, Minnal Gupta, Gwendolyn Binder-Scholl, Alfred L. Garfall, Olga Goloubeva, Naseem Kerr, Michael Kalos, Sanjoy K. Sinha, Sandra Westphal, Ashraf Badros, Aaron P. Rapoport, Shari Kronsberg, Simon F. Lacey, Brendan M. Weiss, Jean A. Yared, Jeffrey Finklestein, Bruce L. Levine, Daniel Williams, Nancy M. Hardy, Don L. Siegel, Sarah Bond
Publikováno v:
Nature medicine
Despite recent therapeutic advances, multiple myeloma (MM) remains largely incurable. Herein we report results of a phase I/II trial to evaluate the safety and activity of autologous T-cells engineered to express an affinity-enhanced T-cell receptor
Autor:
Alan D. Bennett, Joanna E. Brewer, Namir J. Hassan, Gerald P. Linette, Leslie A. Litzky, Gwendolyn Binder-Scholl, Helen K. Tayton-Martin, Michael Kalos, Patrick J. Cimino, Nick Pumphrey, Edward A. Stadtmauer, Adam Bagg, Aaron P. Rapoport, Bruce L. Levine, Marcela V. Maus, Joseph Dukes, Dominic P. Smethurst, Carl H. June, Bent K. Jakobsen, Jane Harper, Lyndsey Emery, Beatriz M. Carreno, Andrew B. Gerry
An obstacle to cancer immunotherapy has been that the affinity of T-cell receptors (TCRs) for antigens expressed in tumors is generally low. We initiated clinical testing of engineered T cells expressing an affinity-enhanced TCR against HLA-A*01–re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db4b1b764b63316916d1897b42a8b11
https://europepmc.org/articles/PMC3743463/
https://europepmc.org/articles/PMC3743463/
Autor:
Giovanna Bossi, Minnal Gupta, Brian Cameron, Alison Legg, Namir J. Hassan, Daniel Williams, Vivekanandan Kannan, Francis Grand, Edward A. Stadtmauer, Frayne Bianchi, Nicholas J. Pumphrey, Gwendolyn Binder-Scholl, Jane Harper, Bent K. Jakobsen, Alan D. Bennett, Michael Kalos, James L. Riley, Angel Varela-Rohena, Joanna E. Brewer, Alex Powlesland, Andrew B. Gerry, Gabriela Plesa, Joseph Dukes, Carl H. June, Bruce L. Levine, Annelise Vuidepot, Irina Kulikovskaya, Gerald P. Linette, Aaron P. Rapoport, Katherine Adams
Publikováno v:
Science Translational Medicine. 5
MAGE A3, which belongs to the family of cancer-testis antigens, is an attractive target for adoptive therapy given its reactivation in various tumors and limited expression in normal tissues. We developed an affinity-enhanced T cell receptor (TCR) di
Autor:
Miguel Maroto, Karen Howe, Joanna E. Brewer, Tiago Ferronha, Bent K. Jakobsen, Zoltan Ferjentsik, Gwendolyn Binder-Scholl, Bruno Laugel, Alexandra Sevko
Publikováno v:
Cancer Research. 76:2281-2281
The DNA methyl transferase inhibitors 5-aza-2’-deoxycytidine (decitabine or DECI) and 5-azacytidine (azacitidine or AZA) have recently been approved for the treatment of a variety of hematologic malignancies. These cytidine analogues remove repress
Autor:
Jessie Gavarret, Rebecca Dennis, Steven M. Dunn, Ruth Moysey, Penio Todorov, Bent K. Jakobsen, Nicholas J. Pumphrey, Andy D. Johnson, Yi Li, Katherine Adams, Deborah H. Sutton, Samantha Paston, Emma Baston, Annelise Vuidepot, Rebecca Ashfield, Joanna E. Brewer, Nikolai Lissin, Brian Cameron, Malkit Sami, Fang Yuan
Publikováno v:
Proteincell. 1(12)
Using directed mutagenesis and phage display on a soluble fragment of the human immunoglobulin super-family receptor ILT2 (synonyms: LIR1, MIR7, CD85j), we have selected a range of mutants with binding affinities enhanced by up to 168,000-fold toward
Autor:
Ashraf Badros, Alan D. Bennett, Eduardo Davila, Tom Holdich, Sandra Wesphal, Nancy M. Hardy, Marylène Fortin, Bent K. Jakobsen, Aaron P. Rapoport, Nick Pumphrey, Brendan M. Weiss, Helen K. Tayton-Martin, Carl H. June, Gwendolyn Binder-Scholl, Ryan Wong, Jeffrey Finkelstein, Bruce L. Levine, Naseem Kerr, Edward A. Stadtmauer, Sunita Philip, Sarah Bond, Andrew B. Gerry, Michael Kalos, Yoav Peretz, Saul Yanovich, Luca Melchiori, Lilliam Ribeiro, Joanna E. Brewer, Dan T. Vogl, Simon F. Lacey, Jean A. Yared
Publikováno v:
Cancer Research. 75:4701-4701
Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA Adoptive immunotherapy for cancer has been limited by a lack of antigen specificity, low levels of target expression, and failure to break self-tolerance. We hypothesize
Autor:
Elke Jäger, Bent K. Jakobsen, Tara Mahon, Brian Cameron, Julia Karbach, Deborah H. Sutton, Maxine E. Hill, Vincenzo Cerundolo, Nikolai Lissin, Rebecca E. Mullings, Paresh Vyas, Ji-Li Chen, Marco A. Purbhoo, Joanna E. Brewer
Publikováno v:
Scopus-Elsevier
Presentation of intracellular tumor-associated Ags (TAAs) in the context of HLA class I molecules offers unique cancer-specific cell surface markers for the identification and targeting of tumor cells. For most peptide Ags, the levels of and variatio