Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Joanna E, Klementowicz"'
Autor:
Mahrukh A, Huseni, Lifen, Wang, Joanna E, Klementowicz, Kobe, Yuen, Beatrice, Breart, Christine, Orr, Li-Fen, Liu, Yijin, Li, Vinita, Gupta, Congfen, Li, Deepali, Rishipathak, Jing, Peng, Yasin, Şenbabaoǧlu, Zora, Modrusan, Shilpa, Keerthivasan, Shravan, Madireddi, Ying-Jiun, Chen, Eleanor J, Fraser, Ning, Leng, Habib, Hamidi, Hartmut, Koeppen, James, Ziai, Kenji, Hashimoto, Marcella, Fassò, Patrick, Williams, David F, McDermott, Jonathan E, Rosenberg, Thomas, Powles, Leisha A, Emens, Priti S, Hegde, Ira, Mellman, Shannon J, Turley, Mark S, Wilson, Sanjeev, Mariathasan, Luciana, Molinero, Mark, Merchant, Nathaniel R, West
Publikováno v:
Cell reports. Medicine.
Although immune checkpoint inhibitors (ICIs) are established as effective cancer therapies, overcoming therapeutic resistance remains a critical challenge. Here we identify interleukin 6 (IL-6) as a correlate of poor response to atezolizumab (anti-PD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bcbbc350b5cf438cceeb2d1bb3b0f44b
https://pubmed.ncbi.nlm.nih.gov/36599350
https://pubmed.ncbi.nlm.nih.gov/36599350
Autor:
Sarah E. Headland, Hart S. Dengler, Daqi Xu, Grace Teng, Christine Everett, Rojo A. Ratsimandresy, Donghong Yan, Jing Kang, Kirthana Ganeshan, Evgeniya V. Nazarova, Sarah Gierke, Christopher J. Wedeles, Riccardo Guidi, Daryle J. DePianto, Katrina B. Morshead, Alison Huynh, Jessica Mills, Sean Flanagan, Shannon Hambro, Victor Nunez, Joanna E. Klementowicz, Yongchang Shi, Jianyong Wang, Jack Bevers, Vladimir Ramirez-Carrozzi, Rajita Pappu, Alex Abbas, Jason Vander Heiden, David F. Choy, Rajbharan Yadav, Zora Modrusan, Reynold A. Panettieri, Cynthia Koziol-White, William F. Jester, Brendan J. Jenkins, Yi Cao, Christine Clarke, Cary Austin, Daniel Lafkas, Min Xu, Paul J. Wolters, Joseph R. Arron, Nathaniel R. West, Mark S. Wilson
Publikováno v:
Science translational medicine. 14(627)
Exacerbations of symptoms represent an unmet need for people with asthma. Bacterial dysbiosis and opportunistic bacterial infections have been observed in, and may contribute to, more severe asthma. However, the molecular mechanisms driving these exa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46323ac4e1c7c49de3c9a3a4fd365072
https://pubmed.ncbi.nlm.nih.gov/35110748
https://pubmed.ncbi.nlm.nih.gov/35110748
Autor:
Mahrukh A. Huseni, Lifen Wang, Joanna E. Klementowicz, Kobe Yuen, Beatrice Breart, Christine Orr, Li-fen Liu, Yijin Li, Vinita Gupta, Congfen Li, Deepali Rishipathak, Jing Peng, Yasin Şenbabaoǧlu, Zora Modrusan, Shilpa Keerthivasan, Shravan Madireddi, Ying-Jiun Chen, Eleanor J. Fraser, Ning Leng, Habib Hamidi, Hartmut Koeppen, James Ziai, Kenji Hashimoto, Marcella Fassò, Patrick Williams, David F. McDermott, Jonathan E. Rosenberg, Thomas Powles, Leisha A. Emens, Priti S. Hegde, Ira Mellman, Shannon J. Turley, Mark S. Wilson, Sanjeev Mariathasan, Luciana Molinero, Mark Merchant, Nathaniel R. West
Publikováno v:
Cell Reports Medicine. 4:100878
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0d80979e302b8951f90b2e33323465f
https://doi.org/10.1016/j.xcrm.2022.100878
https://doi.org/10.1016/j.xcrm.2022.100878
Autor:
John J Worthington, Joanna E Klementowicz, Sayema Rahman, Beata I Czajkowska, Catherine Smedley, Herman Waldmann, Tim Sparwasser, Richard K Grencis, Mark A Travis
Publikováno v:
PLoS Pathogens, Vol 9, Iss 10, p e1003675 (2013)
Chronic intestinal parasite infection is a major global health problem, but mechanisms that promote chronicity are poorly understood. Here we describe a novel cellular and molecular pathway involved in the development of chronic intestinal parasite i
Externí odkaz:
https://doaj.org/article/896c37c39a0648e6bc82b41a1f9e89d0
Autor:
Ashley Mahne, Allyson Spence, Qizhi Tang, Ansuman T. Satpathy, Vinh Son Nguyen, Kenneth M. Murphy, Joanna E. Klementowicz
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950), vol 199, iss 1
In NOD mice, CD11c+ cells increase greatly with islet inflammation and contribute to autoimmune destruction of pancreatic β cells. In this study, we investigated their origin and mechanism of recruitment. CD11c+ cells in inflamed islets resembled cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1ed9ed82b66cccff6a8885b788bf40
https://escholarship.org/uc/item/6230v2hq
https://escholarship.org/uc/item/6230v2hq
Autor:
Catherine Smedley, Richard K. Grencis, Joanna E. Klementowicz, Beata I. Czajkowska, Tim Sparwasser, Sayema Rahman, Mark A. Travis, John J. Worthington, Herman Waldmann
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 9, Iss 10, p e1003675 (2013)
Worthington, J J, Klementowicz, J E, Rahman, S, Czajkowska, B I, Smedley, C, Waldmann, H, Sparwasser, T, Grencis, R K & Travis, M A 2013, ' Loss of the TGFβ-Activating Integrin αvβ8 on Dendritic Cells Protects Mice from Chronic Intestinal Parasitic Infection via Control of Type 2 Immunity ', PL o S Pathogens, vol. 9, no. 10, e1003675 . https://doi.org/10.1371/journal.ppat.1003675, https://doi.org/10.1371/journal.ppat.1003675
PLoS Pathogens, Vol 9, Iss 10, p e1003675 (2013)
Worthington, J J, Klementowicz, J E, Rahman, S, Czajkowska, B I, Smedley, C, Waldmann, H, Sparwasser, T, Grencis, R K & Travis, M A 2013, ' Loss of the TGFβ-Activating Integrin αvβ8 on Dendritic Cells Protects Mice from Chronic Intestinal Parasitic Infection via Control of Type 2 Immunity ', PL o S Pathogens, vol. 9, no. 10, e1003675 . https://doi.org/10.1371/journal.ppat.1003675, https://doi.org/10.1371/journal.ppat.1003675
Chronic intestinal parasite infection is a major global health problem, but mechanisms that promote chronicity are poorly understood. Here we describe a novel cellular and molecular pathway involved in the development of chronic intestinal parasite i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc43acf4a3725e70ba0fe7986a723167
https://ora.ox.ac.uk/objects/uuid:e2cf8332-9f5a-45a4-9087-d4e7b5f390a4
https://ora.ox.ac.uk/objects/uuid:e2cf8332-9f5a-45a4-9087-d4e7b5f390a4
Autor:
Joanna E, Klementowicz, Ashley E, Mahne, Allyson, Spence, Vinh, Nguyen, Ansuman T, Satpathy, Kenneth M, Murphy, Qizhi, Tang
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 199(1)
CD11c+ cells increase greatly with islet inflammation in non-obese diabetic mice and contribute to autoimmune destruction of pancreatic beta cells. In this study, we investigated their origin and mechanism of recruitment. CD11c+ cells in inflamed isl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ebe6c5feba2c01225d05762127516716
https://pubmed.ncbi.nlm.nih.gov/28550204
https://pubmed.ncbi.nlm.nih.gov/28550204
Publikováno v:
Trends in Biochemical Sciences. 36:47-54
Transforming growth factor beta (TGFβ) controls numerous cellular responses, including proliferation, differentiation, apoptosis and migration. This cytokine is produced by many different cell types and has been implicated in the pathogenesis of man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8339014a6322f54346f5b7b22d3a6dcc
https://doi.org/10.1016/j.tibs.2010.08.002
https://doi.org/10.1016/j.tibs.2010.08.002
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950), vol 194, iss 7
Therapeutic regulatory T cells (Tregs) can reverse pre-established autoimmune pathology. In this study, using a mouse model of autoimmune diabetes, we aimed to determine the means by which therapeutic Tregs control islet inflammation. Islet Ag-specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbdaf3261b61b4f1301d82b8b1e9ebab
https://escholarship.org/uc/item/6403487z
https://escholarship.org/uc/item/6403487z
Publikováno v:
Seminars in Immunopathology
Infection with soil-transmitted gastrointestinal parasites, such as Trichuris trichiura, affects more than a billion people worldwide, causing significant morbidity and health problems especially in poverty-stricken developing countries. Despite exte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2486d08df46fbec4d2623cec0c811e29