Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Joanna Denbigh"'
Autor:
Joanna Denbigh, Peter Gardner, Gianfelice Cinque, James Doherty, Alan Raoof, Magda Wolna, Michael D Brown, Ansaf Hussain
Publikováno v:
Doherty, J, Raoof, A, Hussain, A, Wolna, M, Cinque, G, Brown, M, Gardner, P & Denbigh, J 2019, ' Live single cell analysis using synchrotron FTIR microspectroscopy: Development of a simple dynamic flow system for prolonged sample viability ', Analyst, vol. 144, no. 3, pp. 997-1007 . https://doi.org/10.1039/C8AN01566J
A simple, cost-effective liquid sample holder to perform single live cell analysis under an IR microscope. Synchrotron radiation Fourier transform infrared microspectroscopy (SR-microFTIR) of live biological cells has the potential to provide far gre
Autor:
Katarzyna Majzner, Magdalena Jarosz, Nikola Mielniczek, Ewelina Bik, Malgorzata Baranska, Joanna Denbigh, Renata Budzynska
Publikováno v:
The Analyst. 144:6561-6569
This paper describes how tunicamycin (Tu), the most widely used pharmacological agent for inducing endoplasmic reticulum (ER) stress, interacts with endothelial cells. Our results show that tunicamycin enters the cells and accumulates within the ER a
Autor:
Jayne Lawrence, Peter Gardner, Cassio A. Lima, Roy Goodacre, Jayakrupakar Nallala, Howbeer Muhamadali, Joanna Denbigh, Gorkem Bakir, Kathleen M. Gough, Alice Spadea, Nicholas Stone, Oxana Klementieva, Mustafa Kanziz
Publikováno v:
Advanced Chemical Microscopy for Life Science and Translational Medicine 2021.
The recent advent of Optical Photothermal IR (O-PTIR), has enabled for the first time, submicron infrared microscopy in far-field reflection mode with the combination of Raman for simultaneous, correlative IR+Raman microscopy. These unique and exciti
Publikováno v:
Spadea, A, Denbigh, J, Lawrence, M J, Kansiz, M & Gardner, P 2021, ' Analysis of Fixed and Live Single Cells Using Optical Photothermal Infrared with Concomitant Raman Spectroscopy ', Analytical Chemistry, vol. 93, no. 8, pp. 3938-3950 . https://doi.org/10.1021/acs.analchem.0c04846
Analytical Chemistry
Analytical Chemistry
This paper reports the first use of a novel completely optically based photothermal method (O-PTIR) for obtaining infrared spectra of both fixed and living cells using a quantum cascade laser (QCL) and optical parametric oscillator (OPO) laser as exc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d008e77c57586670e2b2b662d5ffab42
https://www.research.manchester.ac.uk/portal/en/publications/analysis-of-fixed-and-live-single-cells-using-optical-photothermal-infrared-with-concomitant-raman-spectroscopy(70481257-27c3-435b-b7f1-0212a780a5c3).html
https://www.research.manchester.ac.uk/portal/en/publications/analysis-of-fixed-and-live-single-cells-using-optical-photothermal-infrared-with-concomitant-raman-spectroscopy(70481257-27c3-435b-b7f1-0212a780a5c3).html
Autor:
Emmy Hoyes, Emmanuelle Claude, Kaye J. Williams, Joanna Denbigh, Lidan Christie, Adam McMahon, Fiona Henderson, Emrys A. Jones, Richard Chapman, Federico Roncaroli
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Scientific Reports
Henderson, F, Jones, E, Denbigh, J, Christie, L, Chapman, R, Hoyes, E, Claude, E, Williams, K, Roncaroli, F & McMahon, A 2020, ' 3D DESI-MS lipid imaging in a xenograft model of glioblastoma: a proof of principle ', Scientific Reports, vol. 10, 16512 (2020) . https://doi.org/10.1038/s41598-020-73518-x
Scientific Reports
Henderson, F, Jones, E, Denbigh, J, Christie, L, Chapman, R, Hoyes, E, Claude, E, Williams, K, Roncaroli, F & McMahon, A 2020, ' 3D DESI-MS lipid imaging in a xenograft model of glioblastoma: a proof of principle ', Scientific Reports, vol. 10, 16512 (2020) . https://doi.org/10.1038/s41598-020-73518-x
Desorption electrospray ionisation mass spectrometry (DESI-MS) can image hundreds of molecules in a 2D tissue section, making it an ideal tool for mapping tumour heterogeneity. Tumour lipid metabolism has gained increasing attention over the past dec
Autor:
Andrew Ridley, Peter Gardner, Bryan A Haines, Richard D. Snook, Mick D. Brown, Nga-Tsing Tang, Joanna Denbigh
Publikováno v:
Molecules, Vol 25, Iss 1652, p 1652 (2020)
Tang, N-T, Snook, R D, Brown, M, Haines, B A, Ridley, A, Gardner, P & Denbigh, J L 2020, ' Fatty-Acid Uptake in Prostate Cancer Cells Using Dynamic Microfluidic Raman Technology ', Molecules, vol. 25 . https://doi.org/10.3390/molecules25071652
Molecules
Volume 25
Issue 7
Tang, N-T, Snook, R D, Brown, M, Haines, B A, Ridley, A, Gardner, P & Denbigh, J L 2020, ' Fatty-Acid Uptake in Prostate Cancer Cells Using Dynamic Microfluidic Raman Technology ', Molecules, vol. 25 . https://doi.org/10.3390/molecules25071652
Molecules
Volume 25
Issue 7
It is known that intake of dietary fatty acid (FA) is strongly correlated with prostate cancer progression but is highly dependent on the type of FAs. High levels of palmitic acid (PA) or arachidonic acid (AA) can stimulate the progression of cancer.
Publikováno v:
Doherty, J, Zhang, Z, Wehbe, K, Cinque, G, Gardner, P & Denbigh, J 2018, ' Increased optical pathlength through aqueous media for the infrared microanalysis of live cells ', Analytical and bioanalytical chemistry . https://doi.org/10.1007/s00216-018-1188-2
Analytical and Bioanalytical Chemistry
Analytical and Bioanalytical Chemistry
The study of live cells using Fourier transform infrared spectroscopy (FTIR) and FTIR microspectroscopy (FT-IRMS) intrinsically yields more information about cell metabolism than comparable experiments using dried or chemically fixed samples. There a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343690d7b0dd03094d5b94d056680c0f
https://www.research.manchester.ac.uk/portal/en/publications/increased-optical-pathlength-through-aqueous-media-for-the-infrared-microanalysis-of-live-cells(a75bd9d1-0493-4215-878b-fadd8c7558c5).html
https://www.research.manchester.ac.uk/portal/en/publications/increased-optical-pathlength-through-aqueous-media-for-the-infrared-microanalysis-of-live-cells(a75bd9d1-0493-4215-878b-fadd8c7558c5).html
Autor:
Joanna Denbigh, Nicholas P. Lockyer
Publikováno v:
Materials Science and Technology. 31:137-147
Time of flight-secondary ion mass spectrometry (ToF-SIMS) is an ideal technique for probing lipids in situ in cells and other biological material. Sophisticated advances in instrumentation and methodology mean that higher sensitivity can be achieved
Autor:
Adam McMahon, Steven Derek Pringle, Fiona Henderson, Emrys A. Jones, Kaye J. Williams, David Coope, Joanna Denbigh
Publikováno v:
Cancer Research. 77:203-203
For the purpose of investigating the potential of automation and high throughput mass spectrometry imaging, we have combined a desorption electrospray ionisation (DESI) MS system with a robotic slide loader. The analysis of tissue sections on multipl
Autor:
Doherty, James1,2,3, Zhang, Zhe1,2, Wehbe, Katia3, Cinque, Gianfelice3, Gardner, Peter1,2 peter.gardner@manchester.ac.uk, Denbigh, Joanna4 j.l.denbigh@salford.ac.uk
Publikováno v:
Analytical & Bioanalytical Chemistry. Sep2018, Vol. 410 Issue 23, p5779-5789. 11p.