Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Joanna D, Holbrook"'
Autor:
Nicolas J. Walker, Mamunur Rashid, Shirong Yu, Helen Bignell, Casper K. Lumby, Carmen M. Livi, Kate Howell, David J. Morley, Sandro Morganella, Daniel Barrell, Shabhonam Caim, Walraj Gosal, Jens Füllgrabe, Thomas J. Charlesworth, Louella Vasquez, Miika Ahdesmäki, Jordan Eizenga, Parul Prabhat, Vitali Proutski, Marie Laurie Murat-Onana, Catherine J. Greenwood, Lisa Kirkwood, Meeta Maisuria-Armer, Mengjie Li, Emma Coats, Victoria Winfield, Lachlan MacBean, Toby Stock, Alice Tomé-Fernandez, Yat Chan, Nasir Sheikh, Paula Golder, Michael Steward, Tobias W. B. Ost, Douglas Stewart, Albert Vilella, Mojtaba Noursalehi, Benedict Paten, Debora Lucarelli, Joanne Mason, Gareth Ridge, Jason Mellad, Suman Shirodkar, Shankar Balasubaramanian, Joanna D. Holbrook
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Early detection of cancer will improve survival rates. The blood biomarker 5-hydroxymethylcytosine has been shown to discriminate cancer. In a large covariate-controlled study of over two thousand individual blood samples, we created, tested
Externí odkaz:
https://doaj.org/article/d0f8987336da4809bf0d43cd15a3ea02
Autor:
Philip Titcombe, Robert Murray, Matthew Hewitt, Elie Antoun, Cyrus Cooper, Hazel M Inskip, Joanna D Holbrook, Keith M Godfrey, Karen Lillycrop, Mark Hanson, Sheila J Barton
Publikováno v:
Epigenetics, Vol 17, Iss 6, Pp 653-664 (2022)
DNA methylation (DNAm) in mammals is mostly examined within the context of CpG dinucleotides. Non-CpG DNAm is also widespread across the human genome, but the functional relevance, tissue-specific disposition, and inter-individual variability has not
Externí odkaz:
https://doaj.org/article/08c0ed1ceebd437e87b7e6a94af68e3e
Autor:
Elie Antoun, Emma S. Garratt, Andrea Taddei, Mark A. Burton, Sheila J. Barton, Phil Titcombe, Leo D. Westbury, Alicia Baczynska, Eugenia Migliavacca, Jerome N. Feige, Holly E. Sydall, Elaine Dennison, Richard Dodds, Helen C. Roberts, Peter Richardson, Avan A. Sayer, Sarah Shaw, Cyrus Cooper, Joanna D. Holbrook, Harnish P. Patel, Keith M. Godfrey, Karen A. Lillycrop, the EpiGen Global Research Consortium
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 1, Pp 240-253 (2022)
Abstract Background Sarcopenia is the age‐related loss of muscle mass, strength, and function. Epigenetic processes such as DNA methylation, which integrate both genetic and environmental exposures, have been suggested to contribute to the developm
Externí odkaz:
https://doaj.org/article/cb246371e61f4db3b368469abfa5c136
Autor:
Elie Antoun, Negusse T Kitaba, Philip Titcombe, Kathryn V Dalrymple, Emma S Garratt, Sheila J Barton, Robert Murray, Paul T Seed, Joanna D Holbrook, Michael S Kobor, David Ts Lin, Julia L MacIsaac, Graham C Burdge, Sara L White, Lucilla Poston, Keith M Godfrey, Karen A Lillycrop, UPBEAT Consortium
Publikováno v:
PLoS Medicine, Vol 17, Iss 11, p e1003229 (2020)
BackgroundHigher maternal plasma glucose (PG) concentrations, even below gestational diabetes mellitus (GDM) thresholds, are associated with adverse offspring outcomes, with DNA methylation proposed as a mediating mechanism. Here, we examined the rel
Externí odkaz:
https://doaj.org/article/b2fe24c15dd443af8b059bf9123fd7ff
Autor:
Xinyi Lin, Ai Ling Teh, Li Chen, Ives Yubin Lim, Pei Fang Tan, Julia L. MacIsaac, Alexander M. Morin, Fabian Yap, Kok Hian Tan, Seang Mei Saw, Yung Seng Lee, Joanna D. Holbrook, Keith M. Godfrey, Michael J. Meaney, Michael S. Kobor, Yap Seng Chong, Peter D. Gluckman, Neerja Karnani
Publikováno v:
BMC Medicine, Vol 15, Iss 1, Pp 1-13 (2017)
Abstract Background Epigenomes are tissue specific and thus the choice of surrogate tissue can play a critical role in interpreting neonatal epigenome-wide association studies (EWAS) and in their extrapolation to target tissue. To develop a better un
Externí odkaz:
https://doaj.org/article/37cb220187a940d19132b0a92f42c521
Autor:
Karen Lillycrop, Robert Murray, Clara Cheong, Ai Ling Teh, Rebecca Clarke-Harris, Sheila Barton, Paula Costello, Emma Garratt, Eloise Cook, Philip Titcombe, Bhuvaneshwari Shunmuganathan, Samantha J. Liew, Yong-Cai Chua, Xinyi Lin, Yonghui Wu, Graham C. Burdge, Cyrus Cooper, Hazel M. Inskip, Neerja Karnani, James C. Hopkins, Caroline E. Childs, Carolina Paras Chavez, Philip C. Calder, Fabian Yap, Yung Seng Lee, Yap Seng Chong, Philip E. Melton, Lawrie Beilin, Rae-Chi Huang, Peter D. Gluckman, Nick Harvey, Mark A. Hanson, Joanna D. Holbrook, Keith M. Godfrey
Publikováno v:
EBioMedicine, Vol 19, Iss C, Pp 60-72 (2017)
Experimental studies show a substantial contribution of early life environment to obesity risk through epigenetic processes. We examined inter-individual DNA methylation differences in human birth tissues associated with child's adiposity. We identif
Externí odkaz:
https://doaj.org/article/b50df7b8db9e47929bab8c7d7eb822c2
Autor:
Sheila J. Barton, Phillip E. Melton, Philip Titcombe, Robert Murray, Sebastian Rauschert, Karen A. Lillycrop, Rae-Chi Huang, Joanna D. Holbrook, Keith M. Godfrey
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Background: Association studies of epigenome-wide DNA methylation and disease can inform biological mechanisms. DNA methylation is often measured in peripheral blood, with heterogeneous cell types with different methylation profiles. Influences such
Externí odkaz:
https://doaj.org/article/2d06ad43744e41b5964d2905ccc7a8e1
Autor:
Sebastian Rauschert, Phillip E. Melton, Graham Burdge, Jeffrey M. Craig, Keith M. Godfrey, Joanna D. Holbrook, Karen Lillycrop, Trevor A. Mori, Lawrence J. Beilin, Wendy H. Oddy, Craig Pennell, Rae-Chi Huang
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Background: Several studies have shown effects of current and maternal smoking during pregnancy on DNA methylation of CpG sites in newborns and later in life. Here, we hypothesized that there are long-term and persistent epigenetic effects following
Externí odkaz:
https://doaj.org/article/b4df1cf0169b44bf83ca1da37370c51a
Autor:
Joanna D. Holbrook, James R. Brown, Michal Magid-Slav, Ganesh M. Sathe, Stephanie F. Van Horn, Wendy S. Halsey, Kurt R. Auger, Michael J. Italia, Yan Zhang
Supplementary Table 2 from Molecular Evolutionary Analysis of Cancer Cell Lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f802d7aebd6f6ab82dbfe08554a3e96
https://doi.org/10.1158/1535-7163.22484649.v1
https://doi.org/10.1158/1535-7163.22484649.v1
Autor:
Joanna D. Holbrook, James R. Brown, Michal Magid-Slav, Ganesh M. Sathe, Stephanie F. Van Horn, Wendy S. Halsey, Kurt R. Auger, Michael J. Italia, Yan Zhang
Supplementary Tables 3-6 from Molecular Evolutionary Analysis of Cancer Cell Lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2102ea6febba429e2b38f1e47439e704
https://doi.org/10.1158/1535-7163.22484646
https://doi.org/10.1158/1535-7163.22484646