Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Joanna C. Bakowska"'
Autor:
Timothy Truong, Zachary A Karlinski, Christopher O'Hara, Maleen Cabe, Hongkyun Kim, Joanna C Bakowska
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130455 (2015)
Troyer syndrome is caused by a mutation in the SPG20 gene, which results in complete loss of expression of the protein spartin. We generated a genetic model of Troyer syndrome in worms to explore the locomotor consequences of a null mutation of the C
Externí odkaz:
https://doaj.org/article/0f27f496e106486d85f1a9f7fd1753e8
Publikováno v:
Biochemical and Biophysical Research Communications. 503:2306-2311
ALIS are large, transient, cytosolic aggregates that serve as storage compartments for ubiquitin-tagged defective ribosomal products. We determined the importance of the protein p62 in the formation of ALIS and demonstrated that two domains of p62—
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f2fb4ee4b8f6541d3066b39a9e1876
https://doi.org/10.1016/j.bbrc.2018.06.153
https://doi.org/10.1016/j.bbrc.2018.06.153
Autor:
Dinesh C Joshi, Joanna C Bakowska
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19290 (2011)
Hereditary spastic paraplegias (HSPs) are a group of neurological disorders characterized clinically by spasticity of lower limbs and pathologically by degeneration of the corticospinal tract. Troyer syndrome is an autosomal recessive HSP caused by a
Externí odkaz:
https://doaj.org/article/f63c3e40ec1a48d8adda5db12d3dccb7
Autor:
Hiroaki Fujii, Molly W. Shaw, Joanna C. Bakowska, Juan de Dios Barajas-López, Teun Munnik, Jes S Pascual, Arjun Tiwari, Xavier Zarza, Matleena Punkkinen
Publikováno v:
Plant and Cell Physiology, 62(1). Oxford University Press
Plants adjust to unfavorable conditions by altering physiological activities such as gene expression. Although previous studies have identified multiple stress-induced genes, the function of many genes during the stress responses remains unclear. Exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::819c25c8d5ed0b730b738db0a819ba80
https://pubmed.ncbi.nlm.nih.gov/33165601
https://pubmed.ncbi.nlm.nih.gov/33165601
Publikováno v:
Journal of visualized experiments : JoVE. (145)
Fluorescence recovery after photobleaching (FRAP) is a microscopy technique that can be used to quantify protein mobility in live cells. In a typical FRAP experiment, steady-state fluorescence is observed by repeated imaging with low-intensity laser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e267588c5b5602f053d6a6cfcd3ac8b2
https://pubmed.ncbi.nlm.nih.gov/30985747
https://pubmed.ncbi.nlm.nih.gov/30985747
Autor:
Alexander Shekhtman, Valentina Dimitrova, Christopher Hooper, Amelia B. Karlsson, Joanna C. Bakowska, Jacqueline Washington
Publikováno v:
Molecular Biology of the Cell
Spartin contributes to the formation of dendritic aggresome-like induced structures (DALIS) through a unique ubiquitin-binding region (UBR). Using NMR and in vitro binding, the authors characterize spartin's UBR and show that DALIS formation depends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0731524d573c144ad92f5d9fa570336
https://doi.org/10.1091/mbc.e13-11-0705
https://doi.org/10.1091/mbc.e13-11-0705
Publikováno v:
Human Molecular Genetics. 21:3604-3618
Hereditary spastic paraplegias (HSPs; SPG1-48) are inherited neurological disorders characterized by lower extremity spasticity and weakness. Loss-of-function mutations in the SPG20 gene encoding spartin cause autosomal recessive Troyer syndrome (SPG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4071982cb4bcd44156789de864bd14c9
https://doi.org/10.1093/hmg/dds191
https://doi.org/10.1093/hmg/dds191
Autor:
Velusamy Rangasamy, James S. Malter, Kun Ping Lu, Joanna C. Bakowska, Subhasis Das, Guri Tzivion, Rajakishore Mishra, Anumantha G. Kanthasamy, Tae Ho Lee, Gautam Sondarva, Ajay Rana, Basabi Rana
Publikováno v:
Proceedings of the National Academy of Sciences. 109:8149-8154
Nuclear protein peptidyl-prolyl isomerase Pin1-mediated prolyl isomerization is an essential and novel regulatory mechanism for protein phosphorylation. Therefore, tight regulation of Pin1 localization and catalytic activity is crucial for its normal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9117e439813a4a8beea00ab14c2c3d62
https://doi.org/10.1073/pnas.1200804109
https://doi.org/10.1073/pnas.1200804109
Publikováno v:
Gene Therapy. 14:1092-1101
One of the challenges of gene targeting is to achieve regulated transgene expression in specific target cells. The hypogonadal (hpg) mice are genetically deficient in hypothalamic gonadotropin-releasing hormone (GnRH) production due to a deletion in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d48a27d67a675c57c4b01903580e1f
https://doi.org/10.1038/sj.gt.3302957
https://doi.org/10.1038/sj.gt.3302957
Publikováno v:
Molecular Biology of the Cell. 18:1683-1692
Troyer syndrome is an autosomal recessive hereditary spastic paraplegia caused by mutation in the spartin (SPG20) gene, which encodes a widely expressed protein of unknown function. This mutation results in premature protein truncation and thus might
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0db410307bf6c7efe412d0004439b21
https://doi.org/10.1091/mbc.e06-09-0833
https://doi.org/10.1091/mbc.e06-09-0833