Disrupted development from head to tail: Pervasive effects of postnatal restricted resources on neurobiological, behavioral, and morphometric outcomes

Autor: Molly H. Kent, Joanna C. Jacob, Gabby Bowen, Janhavi Bhalerao, Stephanie Desinor, Dylan Vavra, Danielle Leserve, Kelly R. Ott, Benjamin Angeles, Michael Martis, Katherine Sciandra, Katherine Gillenwater, Clark Glory, Eli Meisel, Allison Choe, Rene Olivares-Navarrete, Jennifer L. Puetzer, Kelly Lambert

Publikováno v: Frontiers in Behavioral Neuroscience, Vol 16 (2022)

When a maternal rat nurtures her pups, she relies on adequate resources to provide optimal care for her offspring. Accordingly, limited environmental resources may result in atypical maternal care, disrupting various developmental outcomes. In the cu

Externí odkaz: https://doaj.org/article/b50cc9c41e2b48a799cb4ba8e4a38faf

Developmental Lead Exposure in Rats Causes Sex-Dependent Changes in Neurobiological and Anxiety-Like Behaviors that Are Improved by Taurine Co-treatment

Autor: George B, Cruz, Michelle A, Vasquez, Ericka, Cabañas, Jewel N, Joseph, Jourvonn C, Skeen, Kirsten P, Lynch, Isra, Ahmed, Eric B, Khairi, Jalen R, Bonitto, Evan G, Clarke, Samantha, Rubi, Nimra, Hameed, Sukhpreet, Kaur, Neena, Mathew, Teddy F, Dacius, Tokunbo J, Jose, Gabriella, Handford, Samuel, Wolfe, Alex, Feher, Kyle, Tidwell, Jon, Tobin, Enero, Ugalde, Samantha, Fee, Allison, Choe, Katherine, Gillenwater, Bilal, Hindi, Shawna, Pilout, Nick R, Natale, Nick, Domahoski, Molly H, Kent, Joanna C, Jacob, Kelly G, Lambert, Lorenz S, Neuwirth

Publikováno v: Advances in experimental medicine and biology. 1370

Lead (Pb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a18494c2d314535f52e7bcc5ea4bb043
https://pubmed.ncbi.nlm.nih.gov/35882819

The Guts of the Opioid Crisis

Autor: Karan H. Muchhala, Joanna C. Jacob, William L. Dewey, Hamid I. Akbarali, Minho Kang

Publikováno v: Physiology (Bethesda)

Bidirectional interactions of the gut epithelium with commensal bacteria are critical for maintaining homeostasis within the gut. Chronic opioid exposure perturbs gut homeostasis through a multitude of neuro-immune-epithelial mechanisms, resulting in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e48aa21c1d56f6a71aa72058ff7eafd
https://pubmed.ncbi.nlm.nih.gov/34431418

Rapid tolerance to morphine in the myenteric neurons of the small intestine is independent of β-arrestin-2 and mediated by PKC

Autor: Minho Kang, William L. Dewey, Imran Alam, A.H. Khan, Shahzeb Hasan, Joanna C. Jacob, Karan H. Muchhala, Hamid I. Akbarali

Background and PurposeG-protein biased μ-opioid agonists against β-arrestin-2 activation are being investigated to reduce adverse effects. While opioid tolerance is strongly linked to the development of dependence, there is a dissociation between t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b05074d61f5d03a17f3b581ecb6739aa
https://doi.org/10.1101/2020.07.17.209437

Ethanol Reversal of Tolerance to the Antinociceptive Effects of Oxycodone and Hydrocodone

Autor: Justin L. Poklis, William L. Dewey, Joanna C. Jacob, Graeme Henderson, Hamid I. Akbarali

Publikováno v: Jacob, J C, Poklis, J L, Akbarali, H I, Henderson, G & Dewey, W L 2017, ' Ethanol Reversal of Tolerance to the Antinociceptive Effects of Oxycodone and Hydrocodone ', Journal of Pharmacology and Experimental Therapeutics, vol. 362, no. 1, pp. 45-52 . https://doi.org/10.1124/jpet.117.241083

This study compared the development of tolerance to two orally bioavailable prescription opioids, oxycodone and hydrocodone, to that of morphine, and the reversal of this tolerance by ethanol. Oxycodone (s.c.) was significantly more potent in the mou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3d12ea671e8652398e4158c2c2aa76
https://doi.org/10.1124/jpet.117.241083