Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Joanna Brzostek"'
Autor:
Xiang Zhao, Liang-Zhe Wu, Esther K. Y. Ng, Kerisa W. S. Leow, Qianru Wei, Nicholas R. J. Gascoigne, Joanna Brzostek
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Under physiological conditions, CD8+ T cells need to recognize low numbers of antigenic pMHC class I complexes in the presence of a surplus of non-stimulatory, self pMHC class I on the surface of the APC. Non-stimulatory pMHC have been shown to enhan
Externí odkaz:
https://doaj.org/article/77356d9f19ec4a2eb49a0714187b27e7
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Externí odkaz:
https://doaj.org/article/357889be277c4301a32d08979a76aad7
Expansion of an Unusual Virtual Memory CD8+ Subpopulation Bearing Vα3.2 TCR in Themis-Deficient Mice
Autor:
Mukul Prasad, Lukasz Wojciech, Joanna Brzostek, Jianfang Hu, Yen Leong Chua, Desmond Wai Hon Tung, Jiawei Yap, Vasily Rybakin, Nicholas R. J. Gascoigne
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Deletion of the gene for Themis affects T cell selection in the thymus, which would be expected to affect the TCR repertoire. We found an increased proportion of cells expressing Vα3.2 (TRAV9N-3) in the peripheral CD8+ T cell population in mice with
Externí odkaz:
https://doaj.org/article/61b4b97101114a488a41db6a2a5ea543
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract Activation of the T cell receptor (TCR) leads to the generation of a network of signaling events critical to the developmental decision making and activation of T cells. Various experimental approaches continue to identify new signaling mole
Externí odkaz:
https://doaj.org/article/dec67ebcd38c40508545f17c505764fa
Autor:
Xiang Zhao, Shvetha Sankaran, Jiawei Yap, Chien Tei Too, Zi Zong Ho, Garry Dolton, Mateusz Legut, Ee Chee Ren, Andrew K. Sewell, Antonio Bertoletti, Paul A. MacAry, Joanna Brzostek, Nicholas R. J. Gascoigne
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Coagonism, the ability of nonstimulatory antigens to promote T-cell activation, has been reported in mice. Here the authors show that coagonism also occurs in human CD8 T cells, in which a nonstimulatory HIV GAG peptide enhances a specific T-cell res
Externí odkaz:
https://doaj.org/article/e1513454279048d48870135ba8d4a18d
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
T cell activation is mediated by signaling pathways originating from the T cell receptor (TCR). Propagation of signals downstream of the TCR involves a cascade of numerous kinases, some of which have yet to be identified. Through a screening strategy
Externí odkaz:
https://doaj.org/article/6832e293130d4155a448c0301cf6bb9d
Autor:
Joanna Brzostek, Amierah Fatin, Wen Hui Chua, Hui Yi Tan, Thomas Dick, Nicholas R. J. Gascoigne
Publikováno v:
Antibiotics, Vol 9, Iss 10, p 711 (2020)
Mycobacterium abscessus is an emerging health risk to immunocompromised individuals and to people with pre-existing pulmonary conditions. As M. abscessus possesses multiple mechanisms of drug resistance, treatments of M. abscessus are of poor efficac
Externí odkaz:
https://doaj.org/article/c66e6409d24d435f8fcec855ae7fd42e
Autor:
Joanna Brzostek, Barbara Kowrygo
Publikováno v:
Polityki Europejskie, Finanse i Marketing, Iss 10(59) (2013)
Celem pracy była analiza i ocena rynku czekolady w Polsce w latach 2005-2011 ze szczególnym uwzględnieniem zachowań nabywczych i konsumpcyjnych starszych konsumentów. W pracy posłużono się wtórnymi i pierwotnymi danymi. Źródłem pierwszych
Externí odkaz:
https://doaj.org/article/1d57510c35d047eab329c67d02d58451
Autor:
Karsten Köhler, Shiqiu Xiong, Joanna Brzostek, Maryam Mehrabi, Philipp Eissmann, Alice Harrison, Shaun-Paul Cordoba, Stephane Oddos, Vladimir Miloserdov, Keith Gould, Nigel J Burroughs, Philip Anton van der Merwe, Daniel M Davis
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e15374 (2010)
It has been suggested that receptor-ligand complexes segregate or co-localise within immune synapses according to their size, and this is important for receptor signaling. Here, we set out to test the importance of receptor-ligand complex dimensions
Externí odkaz:
https://doaj.org/article/0c502ef37862417d9c7e4472e859d27d
Publikováno v:
EMBO reports. 24
T cell activation and effector functions are determined by the affinity of the interaction between T cell receptor (TCR) and its antigenic peptide MHC (pMHC) ligand. A better understanding of the quantitative aspects of TCR-pMHC affinity-dependent T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af0c1ef7617a07e48bef4a85239752a
https://doi.org/10.15252/embr.202254969
https://doi.org/10.15252/embr.202254969