Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Joanna A. Korecka"'
1
Akademický článek
Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice
Autor: Joanna A. Korecka, Ria Thomas, Anthony J. Hinrich, Alyssa M. Moskites, Zach K. Macbain, Penelope J. Hallett, Ole Isacson, Michelle L. Hastings
Publikováno v: Molecular Therapy: Nucleic Acids, Vol 21, Iss , Pp 623-635 (2020)
Parkinson’s disease (PD) is a progressive neurological disorder estimated to affect 7–10 million people worldwide. There is no treatment available that cures or slows the progression of PD. Elevated leucine-rich repeat kinase 2 (LRRK2) activity h
Externí odkaz: https://doaj.org/article/c35d1d9940544cb3b606f79c91e2929b
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2
Akademický článek
Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity
Autor: Oeystein R. Brekk, Joanna A. Korecka, Cecile C. Crapart, Mylene Huebecker, Zachary K. MacBain, Sara Ann Rosenthal, Miguel Sena-Esteves, David A. Priestman, Frances M. Platt, Ole Isacson, Penelope J. Hallett
Publikováno v: Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-14 (2020)
Abstract Sandhoff disease (SD) is a lysosomal storage disease, caused by loss of β-hexosaminidase (HEX) activity resulting in the accumulation of ganglioside GM2. There are shared features between SD and Parkinson’s disease (PD). α-synuclein (aSY
Externí odkaz: https://doaj.org/article/a6679db376524eaf95dfb742563c7bce
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3
Akademický článek
Neurite Collapse and Altered ER Ca2+ Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation
Autor: Joanna A. Korecka, Sebastien Talbot, Teresia M. Osborn, Sherida M. de Leeuw, Simon A. Levy, Eliza J. Ferrari, Alyssa Moskites, Elise Atkinson, Francine M. Jodelka, Anthony J. Hinrich, Michelle L. Hastings, Clifford J. Woolf, Penelope J. Hallett, Ole Isacson
Publikováno v: Stem Cell Reports, Vol 12, Iss 1, Pp 29-41 (2019)
Summary: The Parkinson disease (PD) genetic LRRK2 gain-of-function mutations may relate to the ER pathological changes seen in PD patients at postmortem. Human induced pluripotent stem cell (iPSC)-derived neurons with the PD pathogenic LRRK2 G2019S m
Externí odkaz: https://doaj.org/article/872a0bc4898b44ba96fb040e2470c7bb
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5
Contributors
Autor: Samira Abdulai-Saiku, Stanley H. Appel, Arthur P. Arnold, Lisa M. Arnold, Robert M. Arnold, Alexa Bacha, Miroslav 'Misha' Backonja, Zinzi D. Bailey, Lucinda Bateman, David R. Beers, Anna Berti, Mamta Bhatnagar, Devin K. Binder, Marina Boido, Maura Boldrini, David Borsook, Xandra O. Breakefield, Robert H. Brown, Rami Burstein, Eduardo R. Butelman, Louis R. Caplan, S. Chen, Marie-Françoise Chesselet, Stefan Clemens, Paula R. Clemens, Joseph T. Coyle, John C. DeWitt, Dena B. Dubal, Veljko Dubljević, Eva L. Feldman, Beth A. Fischer, M.C. Flux, J.S. Fortin, Angelisa Frasca, Francesca Garbarini, Thomas Gasser, Charles F. Gillespie, Michael S. Gold, Stefan M. Gold, Randi Hagerman, Regan Hamel, Craig Haney, James C. Harris, Sara Hassani, Norman J. Haughey, Vibol Heng, J. Horn, Rosana-Bristena Ionescu, Raffaele Iorio, David J. Irwin, Henry J. Kaminski, Dalia Khammash, Vikram Khurana, Charlotte Kilstrup-Nielsen, Bhumsoo Kim, Boram Kim, Marieke Klein, Nastassja Koen, Glenn T. Konopaske, Joanna A. Korecka, Birgitte Rahbek Kornum, Mary Jeanne Kreek, Krister Kristensson, Grzegorz Krzak, Linda L. Kusner, Nicoletta Landsberger, Edward B. Lee, Tong Li, Paweł P. Liberski, Christine Lochner, Christopher A. Lowry, J. John Mann, Clara Marincowitz, E.A. Mayer, E.D. Mayer, Iris Coates McCall, Louise D. McCullough, Michael J. Meaney, Claudio Melo de Gusmao, Abhishek L. Menesgere, Emmanuel Mignot, William C. Mobley, Mayra Montalvo, Alisha R. Moreland-Capuia, Marco Neppi-Modona, Alexandra M. Nicaise, Rae Nishi, Orna O'Toole, Cassia Overk, Laurie Ozelius, Matthew P. Parsons, H.B. Penticoff, Luca Peruzzotti-Jametti, Owen M. Peters, Allison Peterson, Jessica M. Phan, Sean J. Pittock, Stefano Pluchino, Thad A. Polk, Araya Puwanant, Shreya K. Rajagopal, Vijayalakshmi Ravindranath, Lynn A. Raymond, Brian Reed, Kerry J. Ressler, Diane L. Ritchie, Leah H. Rubin, Stacey A. Sakowski, Mario A. Saporta, Alena V. Savonenko, Helen E. Scharfman, Bruce K. Shapiro, Nutan Sharma, Cayce K. Shaw, Michael E. Shy, Beata Sikorska, Ethan J. Silverman, Roger P. Simon, Kristina Simonyan, Catrina Sims-Robinson, Richard Jay Smeyne, Clay Smith, Colin Smith, Sharan R. Srinivasan, Dan J. Stein, Christopher D. Stephen, Indu Subramanian, Edina Szabo, Alissa A. Thomas, Luis B. Tovar-y-Romo, Arshya Vahabzadeh, Alessandro Vercelli, Ashley Viera-Ortiz, Mitchell T. Wallin, Donna M. Werling, Thomas Wichmann, Clayton A. Wiley, David R. Williams, Cory Willis, Philip C. Wong, Vadim Yuferov, Weihua Zhao, Michael J. Zigmond, Saša A. Živković
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::243fdcc9a4e15e7cb9744b08ed648667
https://doi.org/10.1016/b978-0-323-85654-6.01002-9
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6
Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice
Autor: Michelle L. Hastings, Zach K. Macbain, Joanna A. Korecka, Ole Isacson, Anthony J. Hinrich, Ria Thomas, Penelope J. Hallett, Alyssa Moskites
Publikováno v: Molecular Therapy: Nucleic Acids, Vol 21, Iss, Pp 623-635 (2020)
Molecular Therapy. Nucleic Acids
Parkinson’s disease (PD) is a progressive neurological disorder estimated to affect 7–10 million people worldwide. There is no treatment available that cures or slows the progression of PD. Elevated leucine-rich repeat kinase 2 (LRRK2) activity h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c39e45bdba202c50ea65c69da2ade7
https://doi.org/10.1016/j.omtn.2020.06.027
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7
Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity
Autor: Penelope J. Hallett, Frances M. Platt, Oeystein Roed Brekk, Cecile C. Crapart, Miguel Sena-Esteves, Sara Ann Rosenthal, Ole Isacson, Zachary K. Macbain, David Priestman, Joanna A. Korecka, Mylene Huebecker
Publikováno v: Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-14 (2020)
Acta Neuropathologica Communications
Sandhoff disease (SD) is a lysosomal storage disease, caused by loss of β-hexosaminidase (HEX) activity resulting in the accumulation of ganglioside GM2. There are shared features between SD and Parkinson’s disease (PD). α-synuclein (aSYN) inclus
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::296bff70ea73227607970e64a9b64e70
http://link.springer.com/article/10.1186/s40478-020-01004-6
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8
Neurite Collapse and Altered ER Ca2+ Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation
Autor: Ole Isacson, Anthony J. Hinrich, Simon A. Levy, Elise Atkinson, Sherida M. de Leeuw, Eliza J. Ferrari, Alyssa Moskites, Sébastien Talbot, Clifford J. Woolf, Penelope J. Hallett, Teresia Osborn, Joanna A. Korecka, Francine M. Jodelka, Michelle L. Hastings
Publikováno v: Stem Cell Reports, Vol 12, Iss 1, Pp 29-41 (2019)
Summary: The Parkinson disease (PD) genetic LRRK2 gain-of-function mutations may relate to the ER pathological changes seen in PD patients at postmortem. Human induced pluripotent stem cell (iPSC)-derived neurons with the PD pathogenic LRRK2 G2019S m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f993e77d09a81f7c9f359c3ea4c53bf5
http://www.sciencedirect.com/science/article/pii/S2213671118304909
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9
Akademický článek
Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling.
Autor: Joanna A Korecka, Ronald E van Kesteren, Eva Blaas, Sonia O Spitzer, Jorke H Kamstra, August B Smit, Dick F Swaab, Joost Verhaagen, Koen Bossers
Publikováno v: PLoS ONE, Vol 8, Iss 5, p e63862 (2013)
Multiple genetic and environmental factors play a role in the development and progression of Parkinson's disease (PD). The main neuropathological hallmark of PD is the degeneration of dopaminergic (DAergic) neurons in the substantia nigra pars compac
Externí odkaz: https://doaj.org/article/b9d57f6d28de438980edd24634c769d1
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10
Repulsive Guidance Molecule a (RGMa) Induces Neuropathological and Behavioral Changes That Closely Resemble Parkinson's Disease
Autor: Ronald E. van Kesteren, Dick F. Swaab, Nienke Ras-Verloop, Sanny Scheffer, R. Jeroen Pasterkamp, Koen Bossers, Elizabeth B. Moloney, August B. Smit, Ruben Eggers, Barbara Hobo, Joanna A. Korecka, Joost Verhaagen
Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience, 37, 9361-9379. Society for Neuroscience
Journal of Neuroscience, 37(39), 9361. Society for Neuroscience
The Journal of Neuroscience, 37(39), 9361-9379. Society for Neuroscience
Korecka, J A, Moloney, E B, Eggers, R, Hobo, B, Scheffer, S, Ras-Verloop, N, Pasterkamp, R J, Swaab, D F, Smit, A B, van Kesteren, R E, Bossers, K & Verhaagen, J 2017, ' Repulsive Guidance Molecule a (RGMa) Induces Neuropathological and Behavioral Changes That Closely Resemble Parkinson's Disease ', The Journal of Neuroscience, vol. 37, no. 39, pp. 9361-9379 . https://doi.org/10.1523/JNEUROSCI.0084-17.2017
Repulsive guidance molecule member a (RGMa) is a membrane-associated or released guidance molecule that is involved in axon guidance, cell patterning, and cell survival. In our previous work, we showed that RGMa is significantly upregulated in the su
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f166c0ec207e06c424341ed27a0792
https://doi.org/10.1523/JNEUROSCI.0084-17.2017
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