Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Joanna Łapczuk-Romańska"'
Autor:
Marek Drozdzik, Joanna Lapczuk-Romanska, Christoph Wenzel, Sylwia Szelag-Pieniek, Mariola Post, Łukasz Skalski, Mateusz Kurzawski, Stefan Oswald
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1334 (2021)
Hepatic drug metabolizing enzymes (DMEs) markedly affect drug pharmacokinetics. Because liver diseases may alter enzymatic function and in turn drug handling and clinical efficacy, we investigated DMEs expression in dependence on liver pathology and
Externí odkaz:
https://doaj.org/article/5d8fca0e121047dd9394a9be7c6ec67c
Autor:
Joanna Lapczuk-Romanska, Diana Busch, Ewa Gieruszczak, Agnieszka Drozdzik, Katarzyna Piotrowska, Robert Kowalczyk, Stefan Oswald, Marek Drozdzik
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 19, p 4825 (2019)
Salivary glands provide secretory functions, including secretion of xenobiotics and among them drugs. However, there is no published information about protein abundance of drug transporters measured using reliable protein quantification methods. Ther
Externí odkaz:
https://doaj.org/article/05471fab576c4287ad8f5ca42bf003ef
Autor:
Maryam Gholizadeh, Joanna Łapczuk-Romańska, Mariola Post, Nina Komaniecka, Seyed Reza Mazlooman, Lars Kaderali, Marek Droździk
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7207 (2023)
Given the substantial correlation between early diagnosis and prolonged patient survival in HCV patients, it is vital to identify a reliable and accessible biomarker. The purpose of this research was to identify accurate miRNA biomarkers to aid in th
Externí odkaz:
https://doaj.org/article/c2923e5eae8547dbb48715773124e9de
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2856 (2023)
The kidney functions not only as a metabolite elimination organ but also plays an important role in pharmacotherapy. The kidney tubule epithelia cells express membrane carriers and transporters, which play an important role in drug elimination, and c
Externí odkaz:
https://doaj.org/article/faf28b5258674d28a73bffb29b6c28b9
Autor:
Sarah Römer, Marleen J. Meyer, Kathrin Klein, Lennart V. Schneider, Johannes Matthaei, Ana Tzvetkova, Joanna Łapczuk-Romańska, Jochen Gaedcke, Marek Droździk, Jürgen Brockmöller, Anne T. Nies, Mladen V. Tzvetkov
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Organic cation transporter 1 (OCT1, SLC22A1) is localized in the sinusoidal membrane of human hepatocytes and mediates hepatic uptake of weakly basic or cationic drugs and endogenous compounds. Common amino acid substitutions in OCT1 were associated
Externí odkaz:
https://doaj.org/article/830b00b369d741069648215b61af6c25
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 17, p 6404 (2020)
Environmental factors contribute to autoimmune disease manifestation, and as regarded today, AhR has become an important factor in studies of immunomodulation. Besides immunological aspects, AhR also plays a role in pharmacological, toxicological and
Externí odkaz:
https://doaj.org/article/72412ab92b744b94ab529f736e1c98f7
Autor:
Marek Droździk, Sylwia Szeląg-Pieniek, Justyna Grzegółkowska, Joanna Łapczuk-Romańska, Mariola Post, Pawel Domagała, Janusz Miętkiewski, Stefan Oswald, Mateusz Kurzawski
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1606 (2020)
Membrane monocarboxylate transporter 1 (SLC16A1/MCT1) plays an important role in hepatocyte homeostasis, as well as drug handling. However, there is no available information about the impact of liver pathology on the transporter levels and function.
Externí odkaz:
https://doaj.org/article/86d54646980a4b6e81c1af1bd57ca1fb
Autor:
Stefan Oswald, Joanna Łapczuk-Romańska, Mateusz Kurzawski, Sylwia Szeląg-Pieniek, Marek Droździk, Maciej Wrzesiński
Publikováno v:
Pharmacological Reports
Background Hepatic enzymes involved in drug metabolism vary markedly in expression, abundance and activity, which affects individual susceptibility to drugs and toxicants. The present study aimed to compare mRNA expression and protein abundance of th
Autor:
Stefan Oswald, Mariola Post, Marek Droździk, Mateusz Kurzawski, Joanna Łapczuk-Romańska, Sylwia Szeląg-Pieniek
Publikováno v:
Pharmacological Reports
Background Wilson’s disease is a genetic disorder inherited in a recessive manner, caused by mutations in the copper-transporter ATP7B. Although it is a well-known disease, currently available treatments are far from satisfactory and their efficacy
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 6404, p 6404 (2020)
International Journal of Molecular Sciences, Vol 21, Iss 6404, p 6404 (2020)
Environmental factors contribute to autoimmune disease manifestation, and as regarded today, AhR has become an important factor in studies of immunomodulation. Besides immunological aspects, AhR also plays a role in pharmacological, toxicological and