Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Joanna Łapczuk-Romańska"'
Autor:
Marek Drozdzik, Joanna Lapczuk-Romanska, Christoph Wenzel, Sylwia Szelag-Pieniek, Mariola Post, Łukasz Skalski, Mateusz Kurzawski, Stefan Oswald
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1334 (2021)
Hepatic drug metabolizing enzymes (DMEs) markedly affect drug pharmacokinetics. Because liver diseases may alter enzymatic function and in turn drug handling and clinical efficacy, we investigated DMEs expression in dependence on liver pathology and
Externí odkaz:
https://doaj.org/article/5d8fca0e121047dd9394a9be7c6ec67c
Autor:
Sarah Römer, Marleen J. Meyer, Kathrin Klein, Lennart V. Schneider, Johannes Matthaei, Ana Tzvetkova, Joanna Łapczuk-Romańska, Jochen Gaedcke, Marek Droździk, Jürgen Brockmöller, Anne T. Nies, Mladen V. Tzvetkov
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Organic cation transporter 1 (OCT1, SLC22A1) is localized in the sinusoidal membrane of human hepatocytes and mediates hepatic uptake of weakly basic or cationic drugs and endogenous compounds. Common amino acid substitutions in OCT1 were associated
Externí odkaz:
https://doaj.org/article/830b00b369d741069648215b61af6c25
Autor:
Maryam Gholizadeh, Joanna Łapczuk-Romańska, Mariola Post, Nina Komaniecka, Seyed Reza Mazlooman, Lars Kaderali, Marek Droździk
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 8; Pages: 7207
Given the substantial correlation between early diagnosis and prolonged patient survival in HCV patients, it is vital to identify a reliable and accessible biomarker. The purpose of this research was to identify accurate miRNA biomarkers to aid in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855837810b316168a452d87278e2a5d2
Publikováno v:
International Journal of Molecular Sciences. 24:2856
The kidney functions not only as a metabolite elimination organ but also plays an important role in pharmacotherapy. The kidney tubule epithelia cells express membrane carriers and transporters, which play an important role in drug elimination, and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::236d9a3a6fdfdb1a35db7beadd9e5f6a
https://doi.org/10.3390/ijms24032856
https://doi.org/10.3390/ijms24032856
Autor:
Stefan Oswald, Joanna Łapczuk-Romańska, Mateusz Kurzawski, Sylwia Szeląg-Pieniek, Marek Droździk, Maciej Wrzesiński
Publikováno v:
Pharmacological Reports
Background Hepatic enzymes involved in drug metabolism vary markedly in expression, abundance and activity, which affects individual susceptibility to drugs and toxicants. The present study aimed to compare mRNA expression and protein abundance of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95aedf573ad2c506e70b3126f531d38a
https://pubmed.ncbi.nlm.nih.gov/34741761
https://pubmed.ncbi.nlm.nih.gov/34741761
Autor:
Stefan Oswald, Mariola Post, Marek Droździk, Mateusz Kurzawski, Joanna Łapczuk-Romańska, Sylwia Szeląg-Pieniek
Publikováno v:
Pharmacological Reports
Background Wilson’s disease is a genetic disorder inherited in a recessive manner, caused by mutations in the copper-transporter ATP7B. Although it is a well-known disease, currently available treatments are far from satisfactory and their efficacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a8442bf9cc712f9b60a609b6d5e10fc
https://pubmed.ncbi.nlm.nih.gov/34117631
https://pubmed.ncbi.nlm.nih.gov/34117631
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 6404, p 6404 (2020)
International Journal of Molecular Sciences, Vol 21, Iss 6404, p 6404 (2020)
Environmental factors contribute to autoimmune disease manifestation, and as regarded today, AhR has become an important factor in studies of immunomodulation. Besides immunological aspects, AhR also plays a role in pharmacological, toxicological and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e39dd14368e872bd4966f9fb0149d9bc
http://europepmc.org/articles/PMC7504141
http://europepmc.org/articles/PMC7504141
Autor:
Pawel Domagala, Mariola Post, Marek Droździk, Joanna Łapczuk-Romańska, Stefan Oswald, Sylwia Szeląg-Pieniek, Janusz Miętkiewski, Mateusz Kurzawski, Justyna Grzegółkowska
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 5
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1606 (2020)
Volume 21
Issue 5
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1606 (2020)
Membrane monocarboxylate transporter 1 (SLC16A1/MCT1) plays an important role in hepatocyte homeostasis, as well as drug handling. However, there is no available information about the impact of liver pathology on the transporter levels and function.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb0ab06c109ebab996f758b5ca52892
Autor:
Stefan Oswald, Marek Droździk, Maciej Wrzesiński, Mateusz Kurzawski, Sylwia Szeląg-Pieniek, Jerzy Sieńko, Joanna Łapczuk-Romańska
Publikováno v:
Pharmacological reports : PR. 71(4)
Background Analysis of results and conclusions in studies dedicated to pathology of the liver are usually based on comparison of pathological liver specimens and control/reference (considered as healthy) tissues. There are two main sources of the con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0228dc077cab75cacf3927613a0f12c
https://pubmed.ncbi.nlm.nih.gov/31207436
https://pubmed.ncbi.nlm.nih.gov/31207436
Autor:
Anna Wajda, Mateusz Kurzawski, Andrzej Niedzielski, Bogusław Machaliński, Joanna Łapczuk-Romańska, Marek Droździk, Ewa Pius-Sadowska
Publikováno v:
Pharmacological reports : PR. 70(5)
Background Vascular endothelial cells (EC) are constantly exposed to endo- and exogenous compounds, which may disturb EC function. One of the protecting mechanisms against chemicals consists of drug metabolizing enzymes and transporter proteins regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff013651e9a2bbfef4722d07f88ea4b
https://pubmed.ncbi.nlm.nih.gov/30092417
https://pubmed.ncbi.nlm.nih.gov/30092417