Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Joann P. Palma"'
Autor:
Edward B. Reilly, Andrew M. Scott, Hui K. Gan, Thomas John, Puey-Ling Chia, Diana Cao, Joann P. Palma, Wenqing Gao, Erwin R. Boghaert, Kedar S. Vaidya, Anatol Oleksijew, Michael J. Mitten, Hugh D. Falls, Mark G. Anderson
In vivo Efficacy of ABBV-321 tumor targeting.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::677c6299c1714e54b6ad5827987299cc
https://doi.org/10.1158/1535-7163.22518654
https://doi.org/10.1158/1535-7163.22518654
Autor:
Edward B. Reilly, Andrew M. Scott, Hui K. Gan, Thomas John, Puey-Ling Chia, Diana Cao, Joann P. Palma, Wenqing Gao, Erwin R. Boghaert, Kedar S. Vaidya, Anatol Oleksijew, Michael J. Mitten, Hugh D. Falls, Mark G. Anderson
ABBV-321 (serclutamab talirine), a next-generation EGFR-targeted antibody–drug conjugate (ADC) incorporates a potent pyrrolobenzodiazepine (PBD) dimer toxin conjugated to the EGFR-targeting ABT-806 affinity-matured AM1 antibody. ABBV-321 follows th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d6b8106485307d7fd6d8f1fb1b654d
https://doi.org/10.1158/1535-7163.c.6542049
https://doi.org/10.1158/1535-7163.c.6542049
Autor:
Debra T. Chao, Eric D. Hsi, Susan E. Morgan-Lappe, Kurt Gish, Diane Hollenbaugh, Sasmita Mishra, Joann P. Palma, Dong Zhang, Josue Samayoa, Subashri Kumar, Thomas McGonigal, Kelly Foster, Rick Powers, Tamar Uziel, Lisa Durkin, Mien Sho, Melvin Fox, Jonathan Hickson, Sonia G. Tanlimco, James W. Purcell
Cross species binding and tolerability of ABBV-085.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::982f60403077744d5cfc6fa3a2c003e3
https://doi.org/10.1158/0008-5472.22419597.v1
https://doi.org/10.1158/0008-5472.22419597.v1
Autor:
Debra T. Chao, Eric D. Hsi, Susan E. Morgan-Lappe, Kurt Gish, Diane Hollenbaugh, Sasmita Mishra, Joann P. Palma, Dong Zhang, Josue Samayoa, Subashri Kumar, Thomas McGonigal, Kelly Foster, Rick Powers, Tamar Uziel, Lisa Durkin, Mien Sho, Melvin Fox, Jonathan Hickson, Sonia G. Tanlimco, James W. Purcell
Figures S1-S7 show LRRC15 RNA and protein expression in cancer, and demonstrate the anti-tumor efficacy of the LRRC15-targeted ADC ABBV-085 in vitro and in vivo as a monotherapy and in combination with standard-of-care therapies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce87f6ad600e2154e056d843f01435f
https://doi.org/10.1158/0008-5472.22419600.v1
https://doi.org/10.1158/0008-5472.22419600.v1
Autor:
Debra T. Chao, Eric D. Hsi, Susan E. Morgan-Lappe, Kurt Gish, Diane Hollenbaugh, Sasmita Mishra, Joann P. Palma, Dong Zhang, Josue Samayoa, Subashri Kumar, Thomas McGonigal, Kelly Foster, Rick Powers, Tamar Uziel, Lisa Durkin, Mien Sho, Melvin Fox, Jonathan Hickson, Sonia G. Tanlimco, James W. Purcell
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f7114cc02667b3ee4fbd00640ed730
https://doi.org/10.1158/0008-5472.22419603.v1
https://doi.org/10.1158/0008-5472.22419603.v1
Autor:
Debra T. Chao, Eric D. Hsi, Susan E. Morgan-Lappe, Kurt Gish, Diane Hollenbaugh, Sasmita Mishra, Joann P. Palma, Dong Zhang, Josue Samayoa, Subashri Kumar, Thomas McGonigal, Kelly Foster, Rick Powers, Tamar Uziel, Lisa Durkin, Mien Sho, Melvin Fox, Jonathan Hickson, Sonia G. Tanlimco, James W. Purcell
Progress in understanding tumor stromal biology has been constrained in part because cancer-associated fibroblasts (CAF) are a heterogeneous population with limited cell-type–specific protein markers. Using RNA expression profiling, we identified t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::168fcc869a754f376a07852c3cd840d9
https://doi.org/10.1158/0008-5472.c.6510423.v1
https://doi.org/10.1158/0008-5472.c.6510423.v1
Autor:
Edward B. Reilly, Louie Naumovski, Joann P. Palma, Edward K. Han, Qian Zhang, Lora Tucker, Erwin R. Boghaert, Kedar S. Vaidya, Anatol Oleksijew, Mark G. Anderson, Jieyi Wang
Purpose: Despite the importance of the MET oncogene in many malignancies, clinical strategies targeting c-Met have benefitted only small subsets of patients with tumors driven by signaling through the c-Met pathway, thereby necessitating selection of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7da2bd78ea69eb0cc09b70d81041cc0c
https://doi.org/10.1158/1078-0432.c.6526458
https://doi.org/10.1158/1078-0432.c.6526458
Autor:
Edward B. Reilly, Louie Naumovski, Joann P. Palma, Edward K. Han, Qian Zhang, Lora Tucker, Erwin R. Boghaert, Kedar S. Vaidya, Anatol Oleksijew, Mark G. Anderson, Jieyi Wang
ABBV-399, a c-Met Antibody Drug Conjugate that Targets Both MET Amplified and c-Met Overexpressing Tumors, Irrespective of MET Pathway Dependence. Figure S1 shows ABBV-399 is internalized upon binding to tumor cells. Figure S2 shows the down-regulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d3a01cbd3c45e92267639c0dd014a8
https://doi.org/10.1158/1078-0432.22466868
https://doi.org/10.1158/1078-0432.22466868
Autor:
Cherrie K. Donawho, David J. Frost, Saul H. Rosenberg, Vincent L. Giranda, Thomas D. Penning, Gui-Dong Zhu, Loren Lasko, Yan Shi, Xuesong Liu, Amanda Niquette, Gail Bukofzer, Paul A. Ellis, Debra Montgomery, Luis E. Rodriguez, Yi-Chun Wang, Joann P. Palma
Supplementary Data from ABT-888 Confers Broad In vivo Activity in Combination with Temozolomide in Diverse Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::333c77c5988d9bdf51e7b3f44368218e
https://doi.org/10.1158/1078-0432.22439922.v1
https://doi.org/10.1158/1078-0432.22439922.v1
Autor:
Cherrie K. Donawho, David J. Frost, Saul H. Rosenberg, Vincent L. Giranda, Thomas D. Penning, Gui-Dong Zhu, Loren Lasko, Yan Shi, Xuesong Liu, Amanda Niquette, Gail Bukofzer, Paul A. Ellis, Debra Montgomery, Luis E. Rodriguez, Yi-Chun Wang, Joann P. Palma
Purpose: ABT-888, currently in phase 2 trials, is a potent oral poly(ADP-ribose) polymerase inhibitor that enhances the activity of multiple DNA-damaging agents, including temozolomide (TMZ). We investigated ABT-888+TMZ combination therapy in multipl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67613654a79b86ec8f269de75f396056
https://doi.org/10.1158/1078-0432.c.6517308.v1
https://doi.org/10.1158/1078-0432.c.6517308.v1