Differential Toll-Like Receptor-Signalling of Burkholderia pseudomallei Lipopolysaccharide in Murine and Human Models.

Autor: Tassili A F Weehuizen, Joann L Prior, Thomas W van der Vaart, Sarah A Ngugi, Sergey A Nepogodiev, Robert A Field, Liesbeth M Kager, Cornelis van 't Veer, Alex F de Vos, W Joost Wiersinga

Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0145397 (2015)

The Gram-negative bacterium Burkholderia pseudomallei causes melioidosis and is a CDC category B bioterrorism agent. Toll-like receptor (TLR)-2 impairs host defense during pulmonary B.pseudomallei infection while TLR4 only has limited impact. We inve

Externí odkaz: https://doaj.org/article/fd71441681d2486eaba25efa5b15a2d1

Identification of a predicted trimeric autotransporter adhesin required for biofilm formation of Burkholderia pseudomallei.

Autor: Natalie R Lazar Adler, Rachel E Dean, Richard J Saint, Mark P Stevens, Joann L Prior, Timothy P Atkins, Edouard E Galyov

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e79461 (2013)

The autotransporters are a large and diverse family of bacterial secreted and outer membrane proteins, which are present in many Gram-negative bacterial pathogens and play a role in numerous environmental and virulence-associated interactions. As par

Externí odkaz: https://doaj.org/article/4b8922e861814d5e8c4f477f7bcd6a5e

Spinning sugars in antigen biosynthesis: characterization of the Coxiella burnetii and Streptomyces griseus TDP-sugar epimerases

Autor: Alice R. Cross, Sumita Roy, Mirella Vivoli Vega, Martin Rejzek, Sergey A. Nepogodiev, Matthew Cliff, Debbie Salmon, Michail N. Isupov, Robert A. Field, Joann L. Prior, Nicholas J. Harmer

Publikováno v: Cross, A R, Roy, S, Vega, M V, Rejzek, M, Nepogodiev, S A, Cliff, M, Salmon, D, Isupov, M N, Field, R A, Prior, J L & Harmer, N J 2022, ' Spinning sugars in antigen biosynthesis: characterization of the Coxiella burnetii and Streptomyces griseus TDP-sugar epimerases ', Journal of Biological Chemistry . https://doi.org/10.1016/j.jbc.2022.101903

The sugars streptose and dihydrohydroxystreptose (DHHS) are unique to the bacteria Streptomyces griseus and Coxiella burnetii, respectively. Streptose forms the central moiety of the antibiotic streptomycin, while DHHS is found in the O-antigen of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9839f4a66560bdc3da5303ad130349b2
https://doi.org/10.1016/j.jbc.2022.101903

Spinning sugars in antigen biosynthesis: a direct study of the Coxiella burnetii and Streptomyces griseus TDP-sugar epimerases

Autor: Robert A. Field, Sergey A. Nepogodiev, Michail N. Isupov, Sumita Roy, Alice Cross, Mirella Vivoli Vega, Martin Rejzek, Joann L. Prior, Nicholas J. Harmer, Matthew J. Cliff, Debbie Salmon

The sugars streptose and dihydrohydroxystreptose (DHHS) are unique to the bacteria Streptomyces griseus and Coxiella burnetii respectively. Streptose forms the central moiety of the antibiotic streptomycin, whilst DHHS is found in the O-antigen of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ecdd5aceb2bc97583c101f5479c1d3e9
https://doi.org/10.1101/2021.10.25.465559

In vitro priming of human T cells by dendritic cells provides a screening tool for candidate vaccines for Burkholderia pseudomallei

Autor: Nicholas R. English, David Bernardo, Durga Reddi, Stella C. Knight, Joann L. Prior, Philip Hendy, Graeme C. Clark, Lydia Durant, Ethel Diane Williamson, Alistair Noble

Publikováno v: Vaccines, Vol 9, Iss 929, p 929 (2021)
Vaccines; Volume 9; Issue 8; Pages: 929

Producción Científica
Murine dendritic cells, when pulsed with heat-killed Burkholderia pseudomallei and used to immunise naïve mice, have previously been shown to induce protective immunity in vivo. We have now demonstrated the in vitro prim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::122beff4ff0058ea1b60da19e1f59cee
http://hdl.handle.net/10044/1/91616