Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Joann Huber"'
Autor:
John W. Phillips, Xin Gu, Mihai Petcu, Molly M. Lin, Ronald E. Painter, Michel Gallant, Lynn Miesel, Kathryn Skorey, Kenneth E. Wilson, David Claveau, Liliana L. Benton-Perdomo, Kathleen Deschamps, Christopher M. Tan, Katherine Young, Andrew Galgoci, John Tam, Christian Lebeau-Jacob, Alexandre Caron, Young-Whan Park, Suzy Lee, Simon Wong, Patrick Beaulieu, Craig A. Parish, Aimie M. Ogawa, Josiane Lafleur, Alex G. Therien, Nancy J. Kevin, Sherman T. Waddell, Robert G. K. Donald, Penny Sue Leavitt, Mary Ann Powles, Joann Huber, Anna A. Michels
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:4662-4670
The resistance of methicillin-resistant Staphylococcus aureus (MRSA) to all β-lactam classes limits treatment options for serious infections involving this organism. Our goal is to discover new agents that restore the activity of β-lactams against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2bc01435a04348f73f58cdb283cf572
https://doi.org/10.1128/aac.00726-12
https://doi.org/10.1128/aac.00726-12
Autor:
Young Whan Park, Katherine Young, John W. Phillips, Karen Dorso, Lynn Miesel, James L. Occi, Ronald E. Painter, Xin Meng, Joann Huber, Stephen Skwish, Robert G. K. Donald, Terry Roemer, Tim S. Waddell, Lisa Wang Jarantow, Russell Onishi, Sang Ho Lee, Michael J. Salvatore, Michael J. Szymonifka
Publikováno v:
Chemistry & Biology. 16(8):837-848
Methicillin-resistant Staphylococcus aureus (MRSA) is a major nosocomial and community-acquired pathogen for which few existing antibiotics are efficacious. Here we describe two structurally related synthetic compounds that potentiate beta-lactam act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d843560a5ad702a011c874b3e1c217
Autor:
Hiranthi Jayasuriya, Gabe Dezeny, Mary Motyl, Francisca Vicente, Joann Huber, Angela Basilio, Deborah L. Zink, Kevin M. Byrne, Javier Collado, Sheo B. Singh, Mary Lee Goldman, Gerald F. Bills
Publikováno v:
The Journal of Antibiotics. 62:265-269
Treatment of drug-resistant bacteria is a significant unmet medical need. This challenge can be met only by the discovery and development of new antibiotics. Antisense technology is one of the newest discovery tools that provides enhanced sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4b57cbed74e6656008fc49e60ca6bd
https://doi.org/10.1038/ja.2009.26
https://doi.org/10.1038/ja.2009.26
Autor:
Javier Collado, Mary Motyl, Gonzalo Platas, Deborah L. Zink, Angela Basilio, John G. Ondeyka, Francisca Vicente, Chaowei Zhang, Gerald F. Bills, Joann Huber, Karen Dorso, Kevin M. Byrne, Sheo B. Singh
Publikováno v:
Journal of Natural Products. 71:1304-1307
Ribosomal protein S4 (RPSD), a part of the ribosomal small subunit, is one of the proteins that is a part of the ribosomal machinery and is a potential new target for the discovery of antibacterial agents. Continued screening of microbial extracts us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5660951b25c10989094ab8464986cb2d
https://doi.org/10.1021/np8001833
https://doi.org/10.1021/np8001833
Autor:
Frank P. DiNinno, Gregory P. Rouen, Jon G. Sundelof, Joanne B. Laub, Mark L. Greenlee, Joann Huber, Gail G. Hammond, Milton L. Hammond
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:3225-3230
The synthesis and biological evaluation of a series of dicationic-substituted 2-fluorenonylcarbapenems is described. This class of compounds showed enhanced water solubility while maintaining potent activity against MRS. Introduction of a 1-β-methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32811c5ac5a3f04df24eaa1c565a4afa
https://doi.org/10.1016/s0960-894x(99)00567-3
https://doi.org/10.1016/s0960-894x(99)00567-3
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2973-2976
A series of amidinium-substituted 2-dibenzofuranylcarbapenems with potent activity against MRSA has been synthesized via a Stille cross-coupling reaction. These new carbapenems show reduced serum protein binding and improved in vivo efficacy as a con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0cba274765990296a6392c59ca6997
https://doi.org/10.1016/s0960-894x(99)00526-0
https://doi.org/10.1016/s0960-894x(99)00526-0
Autor:
James V. Heck, John W. Kozarich, Lynn L. Silver, Joyce Kohler, R Thompson, Charles Gill, Frank P. DiNinno, Joann Huber, Hugh Rosen, Robert R. Wilkening, Jeffrey H. Epstein-Toney, Jon G. Sundelof, Barbara A. Pelak, Karen Dorso, Richard Hajdu, Gail G. Hammond, Kenneth J. Wildonger, Helmut Kropp, Timothy A. Blizzard, Jesse J. Jackson, Ronald W. Ratcliffe, Milton L. Hammond, George R. Lankas
Publikováno v:
Science. 283:703-706
A carbapenem antibiotic, L-786,392, was designed so that the side chain that provides high-affinity binding to the penicillin-binding proteins responsible for bacterial resistance was also the structural basis for ameliorating immunopathology. Expuls
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec914fb7884fd84749274c4d2abcccc
https://doi.org/10.1126/science.283.5402.703
https://doi.org/10.1126/science.283.5402.703
Autor:
Gonzalo Platas, Craig A. Parish, Jenny M. Baxter, Javier Collado, Joann Huber, Karen Dorso, George K. Abruzzo, Antonio Gonzalez, Francisca Vicente, Maria Teresa Diez, Kenneth E. Wilson
Publikováno v:
Journal of Natural Products. 67:1900-1902
The isolation and structure elucidation of 1 from the Basidomycete fungus Baeospora myosura is described. This new ene-triyne antibiotic was most potent against Gram-positive bacteria, while it was less active against Gram-negative bacteria and a yea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d513aac2c6cf2eb51b750fb945cb4a1
https://doi.org/10.1021/np0497853
https://doi.org/10.1021/np0497853
Autor:
Jon G. Sundelof, Earl St. Rose, Kenneth J. Wildonger, Karen Dorso, Timothy A. Blizzard, Sandra P. Szumiloski, Ronald W. Ratcliffe, Sherman T. Waddell, Joyce Kohler, Joann Huber, Robert R. Wilkening, Gail G. Hammond
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1427-1432
A series of sulfur-linked benzothiazolyl carbapenems has been prepared and evaluated against a battery of microorganisms. Many of the compounds displayed good activity against methicillin-resistant Staphylococcus aureus (MRSA). Data is presented whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3e7c77a7ce92529b58445a9083e9a7f
https://doi.org/10.1016/0960-894x(95)00235-l
https://doi.org/10.1016/0960-894x(95)00235-l
Autor:
Thomas N. Salzmann, Jean S. Kahan, Frank P. DiNinno, Joann Huber, David A. Muthard, Helmut Kropp
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:945-948
The discovery and synthesis of the arylcarbapenem 2b possessing potent activity against highly resistant strains of methicillin resistant staphylococci are dislosed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f5a88691499395fd1cb8d0b4d959eb2
https://doi.org/10.1016/0960-894x(95)00149-n
https://doi.org/10.1016/0960-894x(95)00149-n