Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Joann B. Napolitano"'
Autor:
Xinchun Tong, Melanie Latham, Ying Chen, Denise P. Milot, Milton L. Hammond, Amjad Ali, Eugene Tan, Sheryl A. Hyland, Carl P. Sparrow, Qiu Guo, Joann B. Napolitano, Laurence B. Peterson, Samuel D. Wright, Suoyu S. Xu, Qiaolin Deng, Yi-Heng Chen, Gayle E. Taylor, Zhijian Lu, Peter J. Sinclair, Suzanne S. Eveland, Matt S. Anderson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:199-203
SAR studies of the substitution effect on the central phenyl ring of the biphenyl scaffold were carried out using anacetrapib (9a) as the benchmark. The results revealed that the new analogs with substitutions to replace trifluoromethyl (9a) had a si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d23a0727a318e5869d943562cf0bf0
https://doi.org/10.1016/j.bmcl.2011.11.039
https://doi.org/10.1016/j.bmcl.2011.11.039
Autor:
Milton L. Hammond, Anne-Marie Cumiskey, Sheryl A. Hyland, Ray Rosa, Christopher F. Thompson, Amjad Ali, Ying Chen, Suoyu S. Xu, James V. Pivnichny, Xinchun Tong, Qiu Guo, Hong Li, Carl P. Sparrow, Peter J. Sinclair, Joann B. Napolitano, Melanie Latham, Zhijian Lu, Samuel D. Wright, Laurence B. Peterson, Matt S. Anderson, Suzanne S. Eveland, Cameron J. Smith, Gayle E. Taylor, Denise P. Milot
Publikováno v:
Journal of Medicinal Chemistry. 54:4880-4895
The development of the structure-activity studies leading to the discovery of anacetrapib is described. These studies focused on varying the substitution of the oxazolidinone ring of the 5-aryloxazolidinone system. Specifically, it was found that sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9687b925796a3dc579010acb69a718d
https://doi.org/10.1021/jm200484c
https://doi.org/10.1021/jm200484c
Autor:
Suzanne S. Eveland, Laurence B. Peterson, Carl P. Sparrow, Zhijian Lu, Denise P. Milot, Amjad Ali, Joann B. Napolitano, Qiu Guo, Sheryl A. Hyland, Eugene Tan, Suoyu S. Xu, Samuel D. Wright, Ying Chen, Milton L. Hammond, Melanie Latham, Peter J. Sinclair, Ashleigh B. Theberge, Matt S. Anderson, Xinchun Tong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7469-7472
A new class of CETP inhibitors was designed and prepared. These compounds are potent both in vitro and in vivo. The most active compound (12d) has shown an ability to raise HDL significantly in transgenic mouse PD model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24fd2ff15715d0d6f5760db6460b5c89
https://doi.org/10.1016/j.bmcl.2010.10.019
https://doi.org/10.1016/j.bmcl.2010.10.019