Výsledky vyhledávání - "Joann B Sweasy"

Akademický článek

The hematopoietic compartment is sufficient for lupus development resulting from the POLB-Y265C mutation.

Autor: Tania Rahim, Madison A Levinson, Kelly E W Carufe, Matthew Burak, Rithy Meas, Stephen Maher, Alfred L M Bothwell, Naomi Gades, Joann B Sweasy

Publikováno v: PLoS ONE, Vol 17, Iss 4, p e0267913 (2022)

Systemic lupus erythematosus is a chronic disease characterized by autoantibodies, renal and cutaneous disease, and immune complex formation. Emerging evidence suggests that aberrant DNA repair is an underlying mechanism of lupus development. We prev

Externí odkaz: https://doaj.org/article/89a3a8278fd4466b8bc82a4e6f4224b0

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Akademický článek

The Tumor-Associated Variant RAD51 G151D Induces a Hyper-Recombination Phenotype.

Autor: Carolyn G Marsden, Ryan B Jensen, Jennifer Zagelbaum, Eli Rothenberg, Scott W Morrical, Susan S Wallace, Joann B Sweasy

Publikováno v: PLoS Genetics, Vol 12, Iss 8, p e1006208 (2016)

The RAD51 protein plays a key role in the homology-directed repair of DNA double-strand breaks and is important for maintaining genome stability. Here we report on a novel human RAD51 variant found in an aggressive and therapy-refractive breast carci

Externí odkaz: https://doaj.org/article/862a410adb6e4d8390160c03ec59b5dd

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Akademický článek

Temporal coordination of the transcription factor response to H2O2 stress

Autor: Elizabeth Jose, Woody March-Steinman, Bryce A. Wilson, Lisa Shanks, Chance Parkinson, Isabel Alvarado-Cruz, Joann B. Sweasy, Andrew L. Paek

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Oxidative stress from excess H2O2 activates transcription factors that restore redox balance and repair oxidative damage. Although many transcription factors are activated by H2O2, it is unclear whether they are activated at the same H2O2 co

Externí odkaz: https://doaj.org/article/a98eff01ebe8481e85f36c4b70106900

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Akademický článek

A germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformation.

Autor: Ashley Sjolund, Antonia A Nemec, Nicolas Paquet, Aishwarya Prakash, Patrick Sung, Sylvie Doublié, Joann B Sweasy

Publikováno v: PLoS Genetics, Vol 10, Iss 11, p e1004753 (2014)

Thymine DNA glycosylase (TDG) functions in base excision repair, a DNA repair pathway that acts in a lesion-specific manner to correct individual damaged or altered bases. TDG preferentially catalyzes the removal of thymine and uracil paired with gua

Externí odkaz: https://doaj.org/article/93139c9ef2e74d0eb55e6d9ef8a8044f

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Akademický článek

Kinesin 5B (KIF5B) is required for progression through female meiosis and proper chromosomal segregation in mitotic cells.

Autor: Dawit Kidane, Denny Sakkas, Timothy Nottoli, James McGrath, Joann B Sweasy

Publikováno v: PLoS ONE, Vol 8, Iss 4, p e58585 (2013)

The fidelity of chromosomal segregation during cell division is important to maintain chromosomal stability in order to prevent cancer and birth defects. Although several spindle-associated molecular motors have been shown to be essential for cell di

Externí odkaz: https://doaj.org/article/c1e724821c8345d29ccddfd364cb595c

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Akademický článek

A germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformation.

Autor: Jennifer Yamtich, Antonia A Nemec, Agnes Keh, Joann B Sweasy

Publikováno v: PLoS Genetics, Vol 8, Iss 11, p e1003052 (2012)

Several germline single nucleotide polymorphisms (SNPs) have been identified in the POLB gene, but little is known about their cellular and biochemical impact. DNA Polymerase β (Pol β), encoded by the POLB gene, is the main gap-filling polymerase i

Externí odkaz: https://doaj.org/article/12236605d3c5468a9f7cd37693c4cec9

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