Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Joann, Strnad"'
Autor:
Yulia Nefedova, James J. Burke, Dan T. Vogl, Luca Bernabei, Joann Strnad, Hui Deng, Cindy Lin, Marina Li
Figure S1 shows that pharmacological inhibition of PAD4 prevents MM1.S cell-induced NETosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02208100057df69fca19cde9cebffe38
https://doi.org/10.1158/1535-7163.22521690
https://doi.org/10.1158/1535-7163.22521690
Autor:
Yulia Nefedova, James J. Burke, Dan T. Vogl, Luca Bernabei, Joann Strnad, Hui Deng, Cindy Lin, Marina Li
Multiple myeloma is a plasma cell malignancy, which grows in the bone marrow (BM). The major population of cells in the BM is represented by neutrophils and they can form neutrophil extracellular traps (NET). Here, we investigated whether multiple my
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6bf2879da3ec32038a94ae7882bbdca
https://doi.org/10.1158/1535-7163.c.6543114
https://doi.org/10.1158/1535-7163.c.6543114
Autor:
Yulia Nefedova, James J. Burke, Dan T. Vogl, Luca Bernabei, Joann Strnad, Hui Deng, Cindy Lin, Marina Li
Table S1 shows biochemical potency and selectivity of BMS-P5 for PAD4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096675b72ca6f481cd129d6b13ff7617
https://doi.org/10.1158/1535-7163.22521687
https://doi.org/10.1158/1535-7163.22521687
Autor:
Jianqing Li, Daniel Smith, John S. Tokarski, Lihong Cheng, John E. Macor, Javed Khan, Adriana Zupa-Fernandez, Anil Thankappan, Chunjian Liu, Charu Chaudhry, David S. Weinstein, Percy H. Carter, Kathleen M. Gillooly, Kim W. McIntyre, Yifan Zhang, Anjaneya Chimalakonda, Joann Strnad, James Lin, James R. Burke, David J. Shuster, Manoj Chiney, Paul A. Elzinga, Max Ruzanov, Louis J. Lombardo, Charles M. Langevine
Publikováno v:
Journal of Medicinal Chemistry. 64:677-694
A search for structurally diversified Tyk2 JH2 ligands from 6 (BMS-986165), a pyridazine carboxamide-derived Tyk2 JH2 ligand as a clinical Tyk2 inhibitor currently in late development for the treatment of psoriasis, began with a survey of six-membere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c717944d40cbaa5837d6bde470301607
https://doi.org/10.1021/acs.jmedchem.0c01698
https://doi.org/10.1021/acs.jmedchem.0c01698
Autor:
Cindy Lin, Joann Strnad, Yulia Nefedova, James J Burke, Hui Deng, Luca Bernabei, Dan T. Vogl, Marina Li
Publikováno v:
Mol Cancer Ther
Multiple myeloma is a plasma cell malignancy, which grows in the bone marrow (BM). The major population of cells in the BM is represented by neutrophils and they can form neutrophil extracellular traps (NET). Here, we investigated whether multiple my
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14896946cc0bc9148ce06cfa51d955e0
https://doi.org/10.1158/1535-7163.mct-19-1020
https://doi.org/10.1158/1535-7163.mct-19-1020
Autor:
Yanlei Zhang, Jeffrey Tredup, Mertzman Michael E, Nelly Aranibar, Kim W. McIntyre, Kathleen M. Gillooly, Jodi K. Muckelbauer, James R. Burke, Lihong Cheng, Joann Strnad, Celia D’Arienzo, Dawn Mulligan, Stephen T. Wrobleski, Charu Chaudhry, Adriana Zupa-Fernandez, Percy H. Carter, Dianlin Xie, Manoj Chiney, Elizabeth M. Heimrich, Moslin Ryan M, Christine Huang, Xiaoxia Yang, Shuqun Lin, David S. Weinstein, Tokarski John S, Chiehying Chang, Louis J. Lombardo, Huadong Sun, Steven H. Spergel
Publikováno v:
Journal of Medicinal Chemistry. 62:8953-8972
As a member of the Janus (JAK) family of nonreceptor tyrosine kinases, TYK2 plays an important role in mediating the signaling of pro-inflammatory cytokines including IL-12, IL-23, and type 1 interferons. The nicotinamide 4, identified by a SPA-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ce72d9f5c30b5b21e9d4c5dd0ac4218
https://doi.org/10.1021/acs.jmedchem.9b00443
https://doi.org/10.1021/acs.jmedchem.9b00443
Autor:
Charu Chaudhry, Percy H. Carter, Moslin Ryan M, Celia D’Arienzo, James Lin, Jodi K. Muckelbauer, Luisa Salter-Cid, Tracy L. Taylor, Kim W. McIntyre, Chunjian Liu, James R. Burke, Paul A. Elzinga, Hyunsoo Park, Kathleen M. Gillooly, Chiehying Chang, Dianlin Xie, Jing Chen, Lihong Cheng, David S. Weinstein, Cliff Chen, Jeffrey Tredup, Huadong Sun, Peng Li, Louis J. Lombardo, Adriana Zupa-Fernandez, Joann Strnad, John S. Tokarski, Dauh-Rurng Wu, Nelly Aranibar
Publikováno v:
ACS Medicinal Chemistry Letters. 10:383-388
In sharp contrast to a previously reported series of 6-anilino imidazopyridazine based Tyk2 JH2 ligands, 6-((2-oxo-N1-substituted-1,2-dihydropyridin-3-yl)amino)imidazo[1,2-b]pyridazine analogs were found to display dramatically improved metabolic sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c61bca62d250bf5db34601de42b3c25b
https://doi.org/10.1021/acsmedchemlett.9b00035
https://doi.org/10.1021/acsmedchemlett.9b00035
Autor:
Dianlin Xie, Jing Chen, Celia D’Arienzo, Jodi K. Muckelbauer, Nelly Aranibar, John S. Sack, Jeffrey Tredup, Christine Huang, Charu Chaudhry, Joann Strnad, Percy H. Carter, John S. Tokarski, Adriana Zupa-Fernandez, Joseph B. Santella, Yuval Blat, Gardner Daniel S, James R. Burke, James Lin, David S. Weinstein, Moslin Ryan M, Yifan Zhang, Lihong Cheng, Chong-Hwan Chang, Donna L. Pedicord, Chunjian Liu, J. V. Duncia, Huadong Sun
Publikováno v:
MedChemComm. 8:700-712
As a member of the Janus (JAK) family of non-receptor tyrosine kinases, TYK2 mediates the signaling of pro-inflammatory cytokines including IL-12, IL-23 and type 1 interferon (IFN), and therefore represents an attractive potential target for treating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::552547d736fc9e5ccc4dd8b6c4e38854
https://doi.org/10.1039/c6md00560h
https://doi.org/10.1039/c6md00560h
Autor:
Jenny Xie, Sha Li, Adriana Zupa-Fernandez, Celia D’Arienzo, Xiaoxia Yang, Mark D. Cunningham, Moslin Ryan M, Xiadi Zhou, Kim W. McIntyre, Kathleen M. Gillooly, James R. Burke, Joann Strnad, Ian M. Catlett, Charu Chaudhry, Shawn M. Rose, Julie Carman, David S. Weinstein, Elizabeth M. Heimrich, Jinwen Huang, Luisa Salter-Cid, Jian Pang, Stephen T. Wrobleski, Dana Banas, Qihong Zhao, Lihong Cheng, Yifan Zhang, Anjaneya Chimalakonda
Publikováno v:
Science Translational Medicine. 11
TYK2 is a nonreceptor tyrosine kinase involved in adaptive and innate immune responses. A deactivating coding variant has previously been shown to prevent receptor-stimulated activation of this kinase and provides high protection from several common
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5548473043f7e0b73a9eff8ff661ebb4
https://doi.org/10.1126/scitranslmed.aaw1736
https://doi.org/10.1126/scitranslmed.aaw1736
Autor:
Max Ruzanov, David J. Shuster, Manoj Chiney, Kim W. McIntyre, James R. Burke, Celia D’Arienzo, Nelly Aranibar, Elizabeth M. Heimrich, Louis J. Lombardo, Dianlin Xie, Moslin Ryan M, Joann Strnad, Anjaneya Chimalakonda, Lihong Cheng, James Kempson, Adriana Zupa-Fernandez, Javed Khan, Charu Chaudhry, Huadong Sun, Shuqun Lin, Percy H. Carter, Steven H. Spergel, Christine Huang, Dawn Mulligan, Stephen T. Wrobleski, Kathleen M. Gillooly, Yanlei Zhang, Jeffrey Tredup, David S. Weinstein, Tokarski John S, William J. Pitts, Xiaoxia Yang
Publikováno v:
Journal of medicinal chemistry. 62(20)
Small molecule JAK inhibitors have emerged as a major therapeutic advancement in treating autoimmune diseases. The discovery of isoform selective JAK inhibitors that traditionally target the catalytically active site of this kinase family has been a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a281427643b3f6489276fb5c4ffe37
https://pubmed.ncbi.nlm.nih.gov/31603320
https://pubmed.ncbi.nlm.nih.gov/31603320