Výsledky vyhledávání - "Joann, Aaron"

Akademický článek

Phase I Dose Escalation Study of Sodium Stibogluconate (SSG), a Protein Tyrosine Phosphatase Inhibitor, Combined with Interferon Alpha for Patients with Solid Tumors

Autor: Aung Naing, James M. Reuben, Luis H. Camacho, Hui Gao, Bang-Ning Lee, Evan N. Cohen, Claire Verschraegen, Saneese Stephen, Joann Aaron, David Hong, Jennifer Wheler, Razelle Kurzrock

Publikováno v: Journal of Cancer, Vol 2, Iss 1, Pp 81-89 (2011)

Purpose: Sodium stibogluconate (SSG), a small molecule inhibitor of protein tyrosine phosphatases, combined with IFN-alpha-2b (IFN-α) inhibited solid tumor cell line growth in vitro. We conducted a phase I clinical trial with SSG plus IFN-α in adva

Externí odkaz: https://doaj.org/article/fcd7991293204dc1a4077c7f412440e0

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Phase I Dose Escalation Study of Sodium Stibogluconate (SSG), a Protein Tyrosine Phosphatase Inhibitor, Combined with Interferon Alpha for Patients with Solid Tumors

Autor: Claire F. Verschraegen, David S. Hong, Bang Ning Lee, Jennifer J. Wheler, Evan N. Cohen, Razelle Kurzrock, James M. Reuben, Luis H. Camacho, Joann Aaron, Saneese Stephen, Aung Naing, Hui Gao

Publikováno v: Journal of Cancer, vol 2, iss 1
Journal of Cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8789a18bf0b28265b09102110b177f6
https://doi.org/10.7150/jca.2.81

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Patients with Advanced Head and Neck Cancers Have Similar Progression-Free Survival on Phase I Trials and Their Last Food and Drug Administration–Approved Treatment

Autor: Filip Janku, Merrill S. Kies, David S. Hong, Xuemei Wang, Siqing Fu, Razelle Kurzrock, Aung Naing, Ignacio Garrido-Laguna, Gerald S. Falchook, Joann Aaron

Publikováno v: Clinical Cancer Research. 16:4031-4037

Purpose: To compare clinical outcomes of metastatic head and neck cancer patients treated in phase I clinical trials with clinical outcomes of those patients who had their last Food and Drug Administration (FDA)–approved therapy in the setting of m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746de243d9a7a9c83b921982420494ac
https://doi.org/10.1158/1078-0432.ccr-10-0672

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Breast Cancer: Unique Communication Challenges and Strategies to Address them

Autor: Joann Aaron, Patricia A. Parker, Walter F. Baile

Publikováno v: The Breast Journal. 15:69-75

Women with breast cancer have become increasingly more involved on a national and local level in advocating for resources to fight cancer. However, in the context of the relationship with their physicians and other cancer caregivers, much remains to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f7d274f0088c8764e2b5def5886e57d
https://doi.org/10.1111/j.1524-4741.2008.00673.x

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Assessment and Prognostic Significance of Mitotic Index Using the Mitosis Marker Phospho-histone H3 in Low and Intermediate-grade Infiltrating Astrocytomas

Autor: Javier Gonzalez, Christopher E. Pelloski, Caterina Giannini, Howard Colman, Kenneth Aldape, Peter C. Burger, Kenneth R. Hess, Janet M. Bruner, Gregory N. Fuller, Joann Aaron, Lauren A. Langford, Li Huang

Publikováno v: American Journal of Surgical Pathology. 30:657-664

Distinguishing between grade II and grade III diffuse astrocytomas is important both for prognosis and for treatment decision-making. However, current methods for distinguishing between grades based on proliferative potential are suboptimal, making i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b91f76b9fa4a4ec2b05823801d46ac4f
https://doi.org/10.1097/01.pas.0000202048.28203.25

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Patient-physician communication in oncology: past, present, and future

Autor: Joann Aaron, Walter F. Baile

Publikováno v: Current Opinion in Oncology. 17:331-335

Contemporary oncology practice acknowledges the importance of partnering with the patient and family in dealing with the illness. Patients also value their physicians as important sources of support when they provide information about the illness, en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9bc5f134fa045ee4e94dbd98dcd4584
https://doi.org/10.1097/01.cco.0000167738.49325.2c

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A noncoding RNA regulates human protease-activated receptor-1 gene during embryogenesis

Autor: Nageswara R, Madamanchi, Zhao Y, Hu, Fengzhi, Li, Chris, Horaist, Sung-Kwon, Moon, Cam, Patterson, Marschall S, Runge, Johannes, Ruef, Pamela H, Fritz, Joann, Aaron

Publikováno v: Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1576:237-245

Activation of the human protease-activated receptor-1 (PAR-1) by thrombin leads to myriad functions essential for maintaining vascular integrity. Upregulation of PAR-1 expression is considered important in atherosclerosis, angiogenesis and tumor meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2fc4030686f376732df6880ab168d81
https://doi.org/10.1016/s0167-4781(02)00308-1

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Pediatric patients with refractory central nervous system tumors: experiences of a clinical trial combining bevacizumab and temsirolimus

Autor: Sarina A, Piha-Paul, Sang Joon, Shin, Tribhawan, Vats, Nandita, Guha-Thakurta, Joann, Aaron, Michael, Rytting, Eugenie, Kleinerman, Razelle, Kurzrock

Publikováno v: Anticancer research. 34(4)

Pre-clinical findings suggest that combination treatment with bevacizumab and temsirolimus could be effective against malignant pediatric central nervous system (CNS) tumors.Six pediatric patients were treated as part of a phase I trial with intraven

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::de2a778f40454bd1aa6ae320e1ef6cb9
https://pubmed.ncbi.nlm.nih.gov/24692729

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Targeting the molecular chaperone heat shock protein 90 (HSP90): lessons learned and future directions

Autor: Udai Banerji, Joann Aaron, David S. Hong, Goldy C. George, Bahareh Tavana, Razelle Kurzrock

Publikováno v: Cancer treatment reviews. 39(4)

Due to the critical role of heat shock protein 90 (HSP90) in regulating the stability, activity and intracellular sorting of its client proteins involved in multiple oncogenic processes, HSP90 inhibitors are promising therapeutic agents for cancer tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16473648892be651c91f911ac4953a47
https://pubmed.ncbi.nlm.nih.gov/23199899

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Electrocardiograms (ECGs) in phase I anticancer drug development: the MD Anderson Cancer Center experience with 8518 ECGs

Autor: David S. Hong, Razelle Kurzrock, H. Veasey-Rodrigues, Jennifer J. Wheler, E. C. Golden, Joann Aaron, Aung Naing, S. N. Fessahaye, Siqing Fu, Gerald Steven Falchook, Michael S. Ewer, Sijin Wen, Apostolia-Maria Tsimberidou

Publikováno v: Annals of oncology : official journal of the European Society for Medical Oncology. 23(11)

Background Cardiac sequelae from oncologic drugs are important in early cancer drug development. Prolongation of the corrected QT interval (QTc) by noncardiac drugs is the most common cause of drug development delays, nonapprovals and postmarketing w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ba2af7aa50343a778a507df7b6b521
https://pubmed.ncbi.nlm.nih.gov/22745218

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