Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Joane Litvak"'
Autor:
David Sperandio, Shailaja Kasibhatla, Alberto Estevez, Bill Maske, Emma J. Shelton, Jeffrey R. Spencer, Sui Xiong Cai, Ben Cebon, John Drewe, Chris Reed, Jason Oeh, Ling Qiu, Peter Sabbatini, Anthony Neri, Paul A. Sprengeler, Ben Tseng, Jennifer Zeitz, Cindy Brown, Robert Yee, John Herich, Vincent W.-F. Tai, Catherine Magill, John Eksterowicz, Doris Graupe, Joane Litvak, Darren Wong, Julia Lohman, Yong Ni, Seema Kantak, Keith Pararajasingham
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:4554-4558
As a continuation of our efforts to discover novel apoptosis inducers as anticancer agents using a cell-based caspase HTS assay, 2-phenyl-oxazole-4-carboxamide derivatives were identified. The structure–activity relationships of this class of molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d27287e8b70cbad29f2a44c5b17b6a6
https://doi.org/10.1016/j.bmcl.2006.06.018
https://doi.org/10.1016/j.bmcl.2006.06.018
Autor:
Andrew J. Staab, James M. Clark, Steve Weinheimer, Dennis Hernandez, James W. Janc, Joane Litvak, Emma J. Shelton, Jeffrey R. Spencer, Richard Goldsmith, Anthony R. Gangloff, Kenneth D. Rice, David Sperandio, Kap-Sun Yeung, Kyle Elrod, Brian Lee Venables, Nicholas A. Meanwell, Vivian R. Wang, Jason M. Hataye
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:3129-3133
Screening of a diverse set of bisbenzimidazoles for inhibition of the hepatitis C virus (HCV) serine protease NS3/NS4A led to the identification of a potent Zn(2+)-dependent inhibitor (1). Optimization of this screening hit afforded a 10-fold more po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2bf90718813bb49178a8c8937321ab
https://doi.org/10.1016/s0960-894x(02)00680-7
https://doi.org/10.1016/s0960-894x(02)00680-7
Autor:
Roopa Rai, John O. Link, Bradley A. Katz, Joane Litvak, Kenneth D. Rice, Kyle Elrod, Jeffrey R. Spencer, Erik Verner, Jason M. Hataye, Wendy B. Young, Steve Sideris, James W. Janc, Paul A. Sprengeler, Christine Luong, Richard L. Mackman, Mark Rice
Publikováno v:
Journal of Molecular Biology. 307:1451-1486
We describe a new serine protease inhibition motif in which binding is mediated by a cluster of very short hydrogen bonds (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce75ed01444d8ab3d61a2abe017c0228
https://doi.org/10.1006/jmbi.2001.4516
https://doi.org/10.1006/jmbi.2001.4516
Autor:
P.-W. Phuan, Zhijun Ye, R. P. Ubillas, Thien Truong, Donald E. Bierer, Jeffrey M. Dener, Yihong Zhou, M. Flores, Joane Litvak, Qing Lu, Larisa G. Dubenko, R. E. Gerber
Publikováno v:
Journal of Natural Products. 62:824-828
Irlbacholine and a series of related analogues were synthesized and their antifungal activities against Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus were assessed. The natural bisphosphocholine, irlbacholine, was the most pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::475a36344ba5edf11a0f786153b722c2
https://doi.org/10.1021/np980425n
https://doi.org/10.1021/np980425n
Autor:
C. D. Mendez, T. J. Carlson, S.R. King, Pingsheng Zhang, Joane Litvak, L. G. Dubenko, P. A. Imbach, Reimar C. Bruening, N. Waldeck, M. J. Reed, B. K. Noamesi, J. Luo, Qing Lu, Diana M. Fort, R. F. Hector, R. E. Gerber, Shivanand D. Jolad, Donald Bierer
Publikováno v:
Journal of Medicinal Chemistry. 41:894-901
Using an ethnobotanical approach in combination with in vivo-guided fractionation as a means for lead discovery, cryptolepine was isolated as an antihyperglycemic component of Cryptolepis sanguinolenta. Two syntheses of cryptolepine, including an una
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::515258107c52ac5b5e94dc612a02ebfa
https://doi.org/10.1021/jm9704816
https://doi.org/10.1021/jm9704816
Autor:
Donald Bierer, Michael S. Tempesta, Dung L. Thai, Joane Litvak, Larisa G. Dubenko, R. Eric Gerber, Thien V. Truong, Judy Chu
Publikováno v:
The Journal of Organic Chemistry. 60:7646-7653
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2ad862bb8440ef651694b995db454c1
https://doi.org/10.1021/jo00128a043
https://doi.org/10.1021/jo00128a043
Autor:
Emma J. Shelton, Vivian R. Wang, David Sperandio, Gangloff Anthony R, Rice Kenneth D, Joane Litvak
Publikováno v:
Tetrahedron Letters. 42:1441-1443
Tetrabutylammonium fluoride (TBAF) was found to be a mild and efficient catalyst for the synthesis of 3,5-disubstituted-1,2,4-oxadiazoles. Using 0.1–1.0 equivalents of TBAF in THF for 1–24 h at room temperature, alkanoyl- and aroyloxyamidines wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3aef08fa976e4efca697fd8e2593df51
https://doi.org/10.1016/s0040-4039(00)02288-7
https://doi.org/10.1016/s0040-4039(00)02288-7
Autor:
T. V. Truong, Dung L. Thai, D. E. Bierer, Joane Litvak, J. Chu, Larisa G. Dubenko, R. E. Gerber, Michael S. Tempesta
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db77c57bdab6dbd331e8bddb5a202929
https://doi.org/10.1002/chin.199614262
https://doi.org/10.1002/chin.199614262
Autor:
Larisa G. Dubenko, Joane Litvak, Raymond Cooper, Lisa Wang, Donald Bierer, Albert W. Garofalo
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80c312da244bcacb32d07e1517bfbade
https://doi.org/10.1002/chin.199933211
https://doi.org/10.1002/chin.199933211
Autor:
Emma J. Shelton, Gangloff Anthony R, David Sperandio, Rice Kenneth D, Vivian R. Wang, Joane Litvak
Publikováno v:
ChemInform. 32
Tetrabutylammonium fluoride (TBAF) was found to be a mild and efficient catalyst for the synthesis of 3,5-disubstituted-1,2,4-oxadiazoles. Using 0.1–1.0 equivalents of TBAF in THF for 1–24 h at room temperature, alkanoyl- and aroyloxyamidines wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93448dce363179ae86e05a5459d90086
https://doi.org/10.1002/chin.200121115
https://doi.org/10.1002/chin.200121115