Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Joana Sederias"'
Autor:
Maria Carmela Piccirillo, Quincy Chu, Penelope Bradbury, Wei Tu, Courtney H. Coschi, Federica Grosso, Marie Florescu, Manlio Mencoboni, John R. Goffin, Maria Pagano, Fortunato Ciardiello, Fabiana Letizia Cecere, Mark Vincent, Roberto Ferrara, David E. Dawe, Desiree Hao, Christopher W. Lee, Alessandro Morabito, Cesare Gridelli, Luigi Cavanna, Mussawar Iqbal, Normand Blais, Natasha B. Leighl, Paul Wheatley-Price, Ming-Sound Tsao, Francesca Ugo, Hazem El-Osta, Piera Gargiulo, Pierre-Olivier Gaudreau, Dongsheng Tu, Joana Sederias, Pamela Brown-Walker, Francesco Perrone, Lesley Seymour, Scott A. Laurie
Publikováno v:
Journal of Thoracic Oncology. 18:813-819
Autor:
Roger Tsang, Samuel Weiss, Martin Smoragiewicz, Craig Harlos, Sarah Lapointe, Dongsheng Tu, Warren Mason, Joana Sederias, H. Artee Luchman, Lesley Seymour, Mary MacNeil, John P. Rossiter
Publikováno v:
Investigational New Drugs. 38:1137-1144
The PI3K/AKT/mTOR pathway activation plays a central role in glioblastoma multiforme (GBM) development and progression, and in resistance to anti-cancer therapies. Inhibition of the PI3K pathway has been shown to sensitize cultured glioma cells and t
Autor:
Jean Powers, John Lyons, Ashley M. DiPasquale, Donna E. Reece, Vishal Kukreti, Johan Lategan, Irwindeep Sandhu, Joana Sederias, Annette E. Hay, Nizar J. Bahlis, Hao Xu, Lesley Seymour, Alli Murugesan, Tom Kouroukis, Tony Reiman
Publikováno v:
Leukemia & Lymphoma. 57:1463-1466
Although outcomes for patients with multiple myeloma have improved, it remains an incurable malignancy for which new therapies are needed. At a cellular level the Aurora kinases regulate mitotic di...
Autor:
Grzegorz Korpanty, Bruce D. Keith, John R. Goffin, Jean-Pierre M. Ayoub, Scott A. Laurie, Mihaela Mates, Normand Blais, Christoper Lee, Frances A. Shepherd, Desiree Hao, Jeffrey Rothenstein, Donald Morris, Richard Gregg, Joana Sederias, Sara Kuruvilla, Vamsee Torri, Garth Nicholas, Dongsheng Tu, Penelope A. Bradbury, Glenwood D. Goss, Harriet Feilotter, Moustapha Tehfe, Barbara Melosky, Natasha B. Leighl, Lesley Seymour
Publikováno v:
Lung cancer (Amsterdam, Netherlands). 120
Objectives Pelareorep (reolysin), a Dearing strain of reovirus serotype 3, has demonstrated oncolytic activity as single agent and synergy with chemotherapy. We evaluated pelareorep, combined with standard second-line chemotherapy in patients with no
Autor:
Elizabeth Eisenhauer, Joana Sederias, J. Mazurka, Amit M. Oza, A. Doyle, H. Hirte, Christian K. Kollmannsberger, Laurie Elit, Kim N. Chi, W. Walsh, Lillian L. Siu
Publikováno v:
Ann Oncol
Background The purpose of the study was to assess the safety, tolerability, recommended phase II dose (RPTD), and preliminary antitumor activity of the combination of carboplatin–paclitaxel (Taxol)–temsirolimus. Materials and methods: Patients wi
Autor:
Haji Chalchal, R. Grimshaw, Elizabeth Eisenhauer, S. P. Ivy, Joana Sederias, Hal W. Hirte, Amit M. Oza, Susan Ellard, U. Lee, J. Biagi
Publikováno v:
Annals of Oncology. 22:335-340
Purpose Sunitinib is a multitargeted receptor tyrosine kinase inhibitor. We conducted a two-stage phase II study to evaluate the objective response rate of oral sunitinib in recurrent epithelial ovarian cancer. Patients and methods Eligibility requir
Autor:
Joana Sederias, Brian Colman
Publikováno v:
Aquatic Botany. 87:229-234
Germination and dormancy-breaking requirements have been investigated of Chara vulgaris , L. oospores harvested from surface sediments and from the plants of two lakes, Schumacher and Little Pearl in the locality of Timmins, northern Ontario. Oospore
Autor:
Rafal Wierzbicki, Grzegorz Korpanty, Nevin Murray, Bruce Keith, Sara Kuruvilla, Dongsheng Tu, Scott A. Laurie, Normand Blais, Richard Gregg, Joana Sederias, Donald Morris, Garth Nicholas, Penelope A. Bradbury, John R. Goffin, Asif Ahmed, Glenwood D. Goss, Frances A. Shepherd, Christopher W. Lee, Mustapha Tehfe, Lesley Seymour
Publikováno v:
Journal of Clinical Oncology. 34:e20512-e20512
e20512Background: Despite advances associated with the use of targeted therapy, cytotoxic chemotherapy and immunotherapy the treatment of advanced NSCLC remains challenging. In this study we evalua...
Autor:
Ming-Sound Tsao, John Mazurka, Walter H. Gotlieb, J. Biagi, Janet Dancey, Helen Mackay, Diane Provencher, Percy Ivy, Amit M. Oza, Elizabeth Eisenhauer, Katia Tonkin, Paul Hoskins, Prafull Ghatage, Joana Sederias, Laurie Elit, Suzanne Kamel-Reid
Purpose Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene, and loss of function mutations are common and appear to be important in the pathogenesis of endometrial carcinomas. Loss of PTEN causes deregulated phosphatidylinositol-3 kinas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2170ce3fc9b0d456c72e53842cb031de
https://europepmc.org/articles/PMC3158598/
https://europepmc.org/articles/PMC3158598/
Autor:
Helen Mackay, Elizabeth Eisenhauer, Percy Ivy, Gillian Thomas, Kenneth D. Swenerton, Amit M. Oza, Anna V. Tinker, Joana Sederias, Eric Winquist
Publikováno v:
Gynecologic oncology. 116(2)
Objective Vascular endothethial growth factor (VEGF) and stem cell factor (c-KIT) signaling may play a role in the development and progression of cervical carcinoma. Sunitinib malate is an oral, multi-targeted tyrosine kinase inhibitor that inhibits