The Notch ligand DLL1 exerts carcinogenic features in human breast cancer cells.

Autor: Joana Sales-Dias, Gabriela Silva, Márcia Lamy, Andreia Ferreira, Ana Barbas

Publikováno v: PLoS ONE, Vol 14, Iss 5, p e0217002 (2019)

ConclusionsThese findings provide further evidence that DLL1 exerts carcinogenic effects in BC cells. The dissimilar effects of DLL1 downregulation observed amongst MCF-7, BT474, and MDA-MB-231 cells is likely due to their distinctive genetic and bio

Externí odkaz: https://doaj.org/article/fabd4a42e3594afe8ba679ae15b999be

Development of Dl1.72, a Novel Anti-DLL1 Antibody with Anti-Tumor Efficacy against Estrogen Receptor-Positive Breast Cancer

Autor: Sara Alves, Ana Lemos, Maria Raquel Moita, Carolina Matos, Paula A. Videira, Ana T. Matias, Giacomo Domenici, Duarte C. Barral, Pedro M. F. Sousa, Andreia Ferreira, M. Guadalupe Cabral, Ana Barbas, Diogo Casal, Khrystyna Kucheryava, Joana Sales-Dias, Gabriela Silva, Cristina Casalou, Sofia Braga, Clara Barreto, Tiago M. Bandeiras, Catarina Brito

Publikováno v: Cancers, Vol 13, Iss 4074, p 4074 (2021)
Cancers
Volume 13
Issue 16
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

The Notch-signaling ligand DLL1 has emerged as an important player and promising therapeutic target in breast cancer (BC). DLL1-induced Notch activation promotes tumor cell proliferation, survival, migration, angiogenesis and BC stem cell maintenance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37579de6662437a53976b8c6f85321c0
https://www.mdpi.com/2072-6694/13/16/4074

Specific Eco-Evolutionary Contexts in the Mouse Gut Reveal Escherichia coli Metabolic Versatility

Autor: Helena Pereira, Karina B. Xavier, Catarina Pinto, Joana Sales-Dias, Miguel F. Pedro, Isabel Gordo, Jocelyne Demengeot, João Barroso-Batista

Publikováno v: SSRN Electronic Journal.

Members of the gut microbiota are thought to experience strong competition for nutrients. However, how such competition shapes their evolutionary dynamics and depends on intra- and interspecies interactions is poorly known. Here we tested the hypothe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27bda825cfbc7425f7b1d69be7bf43e4
https://doi.org/10.2139/ssrn.3433809

Mundane Objects and the Banality of Evil

Autor: Stewart Clegg, Miguel Pina e Cunha, Arménio Rego, Joana Sales Dias

Publikováno v: Journal of Management Inquiry. 22:325-340

In this article, we study one organization that played a pivotal role in the Cambodian genocide of the 1970s: the S-21 extermination center. We analyze, in particular, how processes of sociomateriality in the death camp contributed to create order an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f2cb1d99fb260c153b821e42e0a5ab4f
https://doi.org/10.1177/1056492612461949

Host AMPK Is a Modulator of Plasmodium Liver Infection

Autor: Joana Sales-Dias, Nil Gural, Margarida T. Grilo Ruivo, Iset Medina Vera, Patrícia Meireles, Maria M. Mota, Liliana Mancio-Silva, Sangeeta N. Bhatia

Publikováno v: Cell Reports
Cell Reports, Vol 16, Iss 10, Pp 2539-2545 (2016)
Elsevier

Summary Manipulation of the master regulator of energy homeostasis AMP-activated protein kinase (AMPK) activity is a strategy used by many intracellular pathogens for successful replication. Infection by most pathogens leads to an activation of host

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30675b2f1c58d52dd85a954a65a9550