Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Joana Paredes"'
Autor:
Irina Fonseca, Cíntia Horta, Ana Sofia Ribeiro, Barbara Sousa, Gaëlle Marteil, Mónica Bettencourt-Dias, Joana Paredes
Publikováno v:
Cell Death and Disease, Vol 14, Iss 2, Pp 1-12 (2023)
Abstract Polo-like kinase 4 (Plk4), the major regulator of centriole biogenesis, has emerged as a putative therapeutic target in cancer due to its abnormal expression in human carcinomas, leading to centrosome number deregulation, mitotic defects and
Externí odkaz:
https://doaj.org/article/0219254cd3364235a1c703b0b1589e7c
Autor:
Eduarda P. Martins, Céline S. Gonçalves, Marta Pojo, Rita Carvalho, Ana S. Ribeiro, Vera Miranda‐Gonçalves, Ricardo Taipa, Fernando Pardal, Afonso A. Pinto, Carlos Custódia, Cláudia C. Faria, Fátima Baltazar, Nuno Sousa, Joana Paredes, Bruno M. Costa
Publikováno v:
Molecular Oncology, Vol 16, Iss 14, Pp 2611-2631 (2022)
Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults. The prognosis of patients is very poor, with a median overall survival of ~ 15 months after diagnosis. Cadherin‐3 (also known as P‐cadherin), a cell–cell adhesio
Externí odkaz:
https://doaj.org/article/226b5a08c45b46729dda3b5a0bc6f9c5
Autor:
Lídia Faria, Sara Canato, Tito T. Jesus, Margarida Gonçalves, Patrícia S. Guerreiro, Carla S. Lopes, Isabel Meireles, Eurico Morais-de-Sá, Joana Paredes, Florence Janody
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 2 (2023)
Externí odkaz:
https://doaj.org/article/d764c050f338408c88e9525ea1c62e25
Publikováno v:
Bone Research, Vol 9, Iss 1, Pp 1-11 (2021)
Abstract The vast majority of patients with advanced breast cancer present skeletal complications that severely compromise their quality of life. Breast cancer cells are characterized by a strong tropism to the bone niche. After engraftment and colon
Externí odkaz:
https://doaj.org/article/85059fe4b4704847948a14ba971f2eba
Autor:
Cátia Branco, Joana Paredes
Publikováno v:
Acta Médica Portuguesa, Vol 35, Iss 2 (2022)
A reparação dos danos que ocorrem na molécula de ADN é fundamental para manter a integridade do genoma e a viabilidade celular. Défices nos mecanismos de reparação desta molécula cursam com um aumento do risco para instabilidade genética e c
Externí odkaz:
https://doaj.org/article/f49d22459b5e44ecb8fb39057a0252fb
Autor:
Francisco Conceição, Daniela M. Sousa, Joshua Loessberg-Zahl, Anke R. Vollertsen, Estrela Neto, Kent Søe, Joana Paredes, Anne Leferink, Meriem Lamghari
Publikováno v:
Materials Today Bio, Vol 13, Iss , Pp 100219- (2022)
Organ-on-a-chip models have emerged as a powerful tool to model cancer metastasis and to decipher specific crosstalk between cancer cells and relevant regulators of this particular niche. Recently, the sympathetic nervous system (SNS) was proposed as
Externí odkaz:
https://doaj.org/article/64a6963e6bbb47e1ab3fe636fe48d5c3
Autor:
Patrícia Carneiro, Ana Margarida Moreira, Joana Figueiredo, Rita Barros, Patrícia Oliveira, Maria Sofia Fernandes, Anabela Ferro, Raquel Almeida, Carla Oliveira, Fátima Carneiro, Fernando Schmitt, Joana Paredes, Sérgia Velho, Raquel Seruca
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-13 (2019)
Abstract Background E-cadherin has been awarded a key role in the aetiology of both sporadic and hereditary forms of gastric cancer. In this study, we aimed to identify molecular interactors that influence the expression and function of E-cadherin as
Externí odkaz:
https://doaj.org/article/f4d68857c4854fe6aa506e715a3e18f9
Publikováno v:
Surgical and Experimental Pathology, Vol 2, Iss 1, Pp 1-6 (2019)
Abstract Background Programmed cell death ligand 1 (PD-L1) is a predictive biomarker of the response of immunotherapy in some types of cancer. In the last years it was described its expression in breast cancer, namely in triple-negative breast cancer
Externí odkaz:
https://doaj.org/article/ed1d65f9a6ec4ef3a265ad05b3fb4d46
Autor:
Mafalda Santos, Marta Ferreira, Patrícia Oliveira, Nuno Mendes, Ana André, André F. Vieira, Joana B. Nunes, Joana Carvalho, Sara Rocha, Mafalda Azevedo, Daniel Ferreira, Inês Reis, João Vinagre, Joana Paredes, Alireza Heravi-Moussavi, Jorge Lima, Valdemar Máximo, Angela Burleigh, Calvin Roskelley, Fátima Carneiro, David Huntsman, Carla Oliveira
Publikováno v:
Biology, Vol 11, Iss 7, p 1046 (2022)
Transitions between epithelial and mesenchymal cellular states (EMT/MET) contribute to cancer progression. We hypothesize that EMT followed by MET promotes cell population heterogeneity, favouring tumour growth. We developed an EMT model by on and of
Externí odkaz:
https://doaj.org/article/7302372388394956b9b27c7225a965ca
Publikováno v:
Cells, Vol 11, Iss 6, p 934 (2022)
Breast cancer is the most common malignancy affecting women worldwide. Importantly, there have been significant improvements in prevention, early diagnosis, and treatment options, which resulted in a significant decrease in breast cancer mortality ra
Externí odkaz:
https://doaj.org/article/1747e7d86bf44212a26430e1be351d32