Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Joana M. Senra"'
Autor:
Ian J. Stratford, Stephen R. Wedge, Mark J. O'Connor, David G. Hirst, Cian M. McCrudden, Kim E. Cherry, Brian A. Telfer, Joana M. Senra
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Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1042a9f1e83738cbd73bc9d740c74824
https://doi.org/10.1158/1535-7163.22497210.v1
https://doi.org/10.1158/1535-7163.22497210.v1
Autor:
Katarzyna B. Leszczynska, Maria A. Hawkins, Ester M. Hammond, Rhea E. Leslie, Joana M. Senra, Somnath Mukherjee, Greg Dobrynin, Jonathan Ient, Adam J. Boumelha, Tim Maughan
Publikováno v:
Radiotherapy and Oncology
Background and Purpose Esophageal cancer has a persistently low 5-year survival rate and has recently been classified as a cancer of unmet need by Cancer Research UK. Consequently, new approaches to therapy are urgently required. Here, we tested the
Autor:
Joana M. Senra, Kaye J. Williams, James P B O'Connor, Duncan Forster, Marie-Claude Asselin, Ester M. Hammond
Publikováno v:
Clinical Oncology; Vol 26
Clinical Oncology
Clinical Oncology
Hypoxia was identified as a microenvironmental component of solid tumours over 60 years ago and was immediately recognised as a potential barrier to therapy through the reliance of radiotherapy on oxygen to elicit maximal cytotoxicity. Over the last
Autor:
Kim E Cherry, Brian A. Telfer, Stephen R. Wedge, Cian M. McCrudden, David G. Hirst, Mark J. O'Connor, Joana M. Senra, Ian J. Stratford
Publikováno v:
Molecular Cancer Therapeutics. 10:1949-1958
PARP-1 is a critical enzyme in the repair of DNA strand breaks. Inhibition of PARP-1 increases the effectiveness of radiation in killing tumor cells. However, although the mechanism(s) are well understood for these radiosensitizing effects in vitro,
Abstract 2562: Affinity-enhanced T-cell receptor (TCR) for adoptive T-cell therapy targeting MAGE-A4
Autor:
Joana M. Senra, Barbara Mino, Manoj Saini, Patrick Hwu, Elizabeht A. Mittendorf, Joseph P. Sanderson, Gwendolyn Binder-Scholl, Andrew B. Gerry, Nicholas J. Pumphrey, Ignacio I. Wistuba, Miguel Maroto, Carmen Behrens, David S. Hong, George S. Blumenschein, Luisa M. Solis, Boris Sepesi, Pamela Villalobos, Rafael G. Amado
Publikováno v:
Cancer Research. 78:2562-2562
Melanoma-associated antigens-A (MAGE-A) are members of an extensive family of cancer/testis (CT) antigens. Although emerging studies highlight the potential role of MAGE-A family members in promoting cancer growth, the biological function of MAGE-A4
Autor:
Maria Isabel Acosta, Joana M. Senra, Ester M. Hammond, Samantha Carrera, Petra J. de Verdier, Mohammad Althubiti, Salvador Macip
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 5, p e97938 (2014)
PLoS ONE, Vol 9, Iss 5, p e97938 (2014)
HIF-1 is a transcription factor that mediates the cellular responses to low oxygen environments, mainly as a result of having an oxygen-labile subunit, HIF-1α. HIF-1α has been carefully studied in the context of severe hypoxic stresses (
Autor:
Isabel M. Pires, Suzanne A. Eccles, Joana M. Senra, Amanda J. Harvey, Ester M. Hammond, Agnieke Wt Broos, Flore-Anne Poujade, Paul N. Span, Nina Jg Blokland
Publikováno v:
Cancer Biology & Therapy, 15, 10, pp. 1350-7
Cancer Biology & Therapy, 15, 1350-7
Pires, IM, Blokland, NJ, Broos, AW, Poujade, FA, Senra, JM, Eccles, SA, Span, PN, Harvey, AJ & Hammond, EM 2014, ' HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion. ', Cancer Biology and Therapy, vol. 15, no. 10, pp. 1350-1357 . https://doi.org/10.4161/cbt.29822
Cancer Biology & Therapy, 15, 1350-7
Pires, IM, Blokland, NJ, Broos, AW, Poujade, FA, Senra, JM, Eccles, SA, Span, PN, Harvey, AJ & Hammond, EM 2014, ' HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion. ', Cancer Biology and Therapy, vol. 15, no. 10, pp. 1350-1357 . https://doi.org/10.4161/cbt.29822
This article has been made available through the Brunel Open Access Publishing Fund. PTK6/Brk is a non-receptor tyrosine kinase overexpressed in cancer. Here we demonstrate that cytosolic PTK6 is rapidly and robustly induced in response to hypoxic co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69d83c265dda1dbc0b731285338914c0
https://hdl.handle.net/2066/138137
https://hdl.handle.net/2066/138137
Autor:
Joana M. Senra, Monica M. Olcina, Isabel M. Pires, Iosifina P. Foskolou, Ester M. Hammond, Anderson J. Ryan, Selvakumar Anbalagan, Yanyan Jiang
Publikováno v:
Molecular Cell
Summary ATM-mediated signaling in response to DNA damage is a barrier to tumorigenesis. Here we asked whether replication stress could also contribute to ATM signaling. We demonstrate that, in the absence of DNA damage, ATM responds to replication st
Publikováno v:
Tumor Microenvironment and Therapy. 1
Tumor hypoxia is a common feature associated with resistance to current anticancer therapies, such as radiotherapy and chemotherapy. Wee1 is a tyrosine kinase regarded as a gatekeeper of the G 2 /M cell cycle transition. Wee1 has recently been highli
Autor:
Joana M. Senra, Ian J. Stratford, Crispin J. Miller, John Simon Hall, Janet Taylor, Peter L. Stern, Rohan Iype, Yaoyong Li, Lucile Armenoult, Catharine M L West, Mark J. O'Connor, Kenneth K Oguejiofor
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86329 (2014)
PLoS ONE
Hall, J S, Iype, R, Senra, J, Taylor, J, Armenoult, L, Oguejiofor, K, Li, Y, Stratford, I, Stern, P L, O'Connor, M J, Miller, C J & West, C M L 2014, ' Investigation of radiosensitivity gene signatures in cancer cell lines ', PLoS ONE, vol. 9, no. 1, e86329 . https://doi.org/10.1371/journal.pone.0086329, https://doi.org/10.1371/journal.pone.0086329, https://doi.org/10.1371/journal.pone.0086329
PLoS ONE
Hall, J S, Iype, R, Senra, J, Taylor, J, Armenoult, L, Oguejiofor, K, Li, Y, Stratford, I, Stern, P L, O'Connor, M J, Miller, C J & West, C M L 2014, ' Investigation of radiosensitivity gene signatures in cancer cell lines ', PLoS ONE, vol. 9, no. 1, e86329 . https://doi.org/10.1371/journal.pone.0086329, https://doi.org/10.1371/journal.pone.0086329, https://doi.org/10.1371/journal.pone.0086329
Intrinsic radiosensitivity is an important factor underlying radiotherapy response, but there is no method for its routine assessment in human tumours. Gene signatures are currently being derived and some were previously generated by expression profi