Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Joana L. C. Sousa"'
Publikováno v:
Molbank, Vol 2023, Iss 2, p M1621 (2023)
2-Styrylchromones (2-SCs) are interesting compounds for their biological properties as well as versatility as starting materials for further transformations. Herein, we disclose a new 2-SC derivative—2,2’-[(1E,1’E)-{[hexa-2,4-diyne-1,6-diylbis(
Externí odkaz:
https://doaj.org/article/0f37984a471e46cf91e5d7c4b5753f17
Publikováno v:
Molbank, Vol 2023, Iss 1, p M1603 (2023)
Voriconazole (VN) is an antifungal drug indicated for the treatment of several fungal infections. Due to its side effects, some works involving late-stage functionalization of VN have been reported in the literature. Here, we disclose a new VN deriva
Externí odkaz:
https://doaj.org/article/fd7983c3f1084217a0727f67fd5f8199
Publikováno v:
Pharmaceuticals, Vol 16, Iss 12, p 1668 (2023)
Artur Silva’s research group has a long history in the field of medicinal chemistry. The development of new synthetic methods for oxygen (mostly polyphenols, e.g., 2- and 3-styrylchromones, xanthones, flavones) and nitrogen (e.g., pyrazoles, triazo
Externí odkaz:
https://doaj.org/article/d2cf383d693b476591911046ae89fb0c
Publikováno v:
Molecules, Vol 27, Iss 15, p 4904 (2022)
Betulinic acid (BA) was used as starting building block to create a library of novel BA-derived compounds containing O- and N-heterocycles. Firstly, BA was converted into methyl betulonate (BoOMe), which was used as intermediate in the developed meth
Externí odkaz:
https://doaj.org/article/8ab82faa076a4c6cae959bfdfb23f5b9
Autor:
Carina Proença, Marisa Freitas, Daniela Ribeiro, Eduardo F. T. Oliveira, Joana L. C. Sousa, Sara M. Tomé, Maria J. Ramos, Artur M. S. Silva, Pedro A. Fernandes, Eduarda Fernandes
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 1216-1228 (2017)
α-Glucosidase inhibitors are described as the most effective in reducing post-prandial hyperglycaemia (PPHG) from all available anti-diabetic drugs used in the management of type 2 diabetes mellitus. As flavonoids are promising modulators of this en
Externí odkaz:
https://doaj.org/article/df98cefa08f24afea7eda482159cb88f
Autor:
Joana L. C. Sousa, Cristiana Gonçalves, Ricardo M. Ferreira, Susana M. Cardoso, Carmen S. R. Freire, Armando J. D. Silvestre, Artur M. S. Silva
Publikováno v:
Antioxidants, Vol 10, Iss 2, p 148 (2021)
The present work aimed at the valorization of biomass derived compounds by their transformation into new added-value compounds with enhanced antioxidant properties. In this context, betulinic acid (BA) was decorated with polyphenolic fragments, and p
Externí odkaz:
https://doaj.org/article/1fec0189b3134914aade130d6f0331cb
Publikováno v:
Molecules, Vol 24, Iss 2, p 355 (2019)
Betulinic acid (BA) and its natural analogues betulin (BN), betulonic (BoA), and 23-hydroxybetulinic (HBA) acids are lupane-type pentacyclic triterpenoids. They are present in many plants and display important biological activities. This review focus
Externí odkaz:
https://doaj.org/article/faa5daf2106c41c98c7788c87c8b7881
Autor:
Joana L. C. Sousa, Patrícia A. B. Ramos, Carmen S. R. Freire, Artur M. S. Silva, Armando J. D. Silvestre
Publikováno v:
Applied Sciences, Vol 8, Iss 12, p 2575 (2018)
The chemical composition of lipophilic bark extracts from Pinus pinaster and Pinus pinea cultivated in Portugal was evaluated using gas chromatography-mass spectrometry. Diterpenic resin acids were found to be the main components of these lipophilic
Externí odkaz:
https://doaj.org/article/6cfd0e27e3504031aa79d538040cf807
Autor:
Hélio M. T. Albuquerque, Artur M. S. Silva, Telmo N. Francisco, Joana L. C. Sousa, Samuel Guieu
Publikováno v:
Synlett. 33:1505-1510
A mild synthesis of 3,5-disubstituted nitrobenzenes from readily available 3-formylchromones is reported. The developed methodology follows a cascade process, promoted by 1,8-diazabicyclo[5.4.0]undec-7-ene. The proposed mechanism involves an initial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad544fdfa95600a9cbe294198dd9ef6c
https://doi.org/10.1055/a-1875-2646
https://doi.org/10.1055/a-1875-2646
Autor:
Marisa Freitas, Ana Oliveira, Artur M. S. Silva, Eduarda Fernandes, Pedro A. Fernandes, Joana L. C. Sousa, Maria J. Ramos, Daniela Ribeiro, Carina Proença
Publikováno v:
Journal of Natural Products. 83:1541-1552
Liver fructose 1,6-bisphosphatase (FBPase) is a recognized regulatory enzyme of the gluconeogenesis pathway, which has emerged as a valid target to control gluconeogenesis-mediated overproduction of glucose. As such, the management of diabetes with F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caaf41f55bdcd4514063c1b6a319126c
https://doi.org/10.1021/acs.jnatprod.0c00014
https://doi.org/10.1021/acs.jnatprod.0c00014