Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Joana I. Soares"'
Autor:
Nikolai V. Lukoyanov, Joana I. Soares, Sérgio G. Almeida, Juliana M. Leite, Alisa N. Lukoyanova, Helena X. Baptista, Gisela H. Maia, Cátia S. Brazete
Publikováno v:
Brain Research Bulletin. 152:95-106
Studies in animal models of epilepsy revealed compromised serotonin (5-HT) transmission between the raphe nuclei and the brain limbic system. The goal of the present study was to evaluate the effects of epilepsy on the structural integrity of the dor
Autor:
Gisela H Maia, José L Quesado, Joana I Soares, Joana M do Carmo, Pedro A Andrade, José P Andrade, Nikolai V Lukoyanov
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84722 (2014)
Treating rats with kainic acid induces status epilepticus (SE) and leads to the development of behavioral deficits and spontaneous recurrent seizures later in life. However, in a subset of rats, kainic acid treatment does not induce overt behaviorall
Externí odkaz:
https://doaj.org/article/a8c82150fceb444d86aa2ef5cb3f469d
Publikováno v:
Journal of Comparative Neurology. 525:2690-2705
The septohippocampal cholinergic neurotransmission has long been implicated in seizures, but little is known about the structural features of this projection system in epileptic brain. We evaluated the effects of experimental epilepsy on the areal de
Autor:
Pedro Andrade, Nikolai V. Lukoyanov, Catarina Da Costa, Maria H. Ferreira, Gisela H. Maia, Joana I. Soares
Publikováno v:
Brain research. 1717
The brain cholinergic system may undergo structural and functional alterations both in human epilepsy and in respective animal models, but the causal relationships between these alterations and epilepsy remain to be established. In this study, we att
Autor:
José Paulo Andrade, Gisela H. Maia, Juliana F. Leite, Joana I. Soares, Liliana L. Luz, Pedro Andrade, Nikolai V. Lukoyanov
Publikováno v:
Behavioural Brain Research. 297:28-36
Mood disorders and major depression are frequently comorbid with epilepsy. While the nature of this comorbidity is not fully understood, multiple lines of evidence suggest that changes in serotonin (5-HT) neurotransmission may be an underlying mechan
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 22
Volume 20
Issue 22
The amygdala is a cerebral region whose function is compromised in temporal lobe epilepsy (TLE). Patients with TLE present cognitive and emotional dysfunctions, of which impairments in recognizing facial expressions have been clearly attributed to am
Publikováno v:
Neuroscience letters. 672
Prior studies showed that epilepsy can be associated with reorganization of the septohippocampal cholinergic fiber system. Using the kainate model of epilepsy, we wished to further examine the structural integrity of the mesopontine tegmental nuclei
Autor:
Tarja Malm, Asla Pitkänen, Mikko Hiltunen, Teemu Natunen, Joana I. Soares, Xavier Ekolle Ndode-Ekane, Pedro Andrade, Jukka Sallinen, Jari Nissinen, Katja M. Kanninen, Olena Shatillo
Publikováno v:
Epilepsy research. 136
Treatment of TBI remains a major unmet medical need, with 2.5 million new cases of traumatic brain injury (TBI) each year in Europe and 1.5 million in the USA. This single-center proof-of-concept preclinical study tested the hypothesis that pharmacol
Publikováno v:
Brain research bulletin. 134
Serotonin is implicated in the regulation of seizures, but whether or not it can potentiate the effects of epileptogenic factors is not fully established. Using the kainic acid model of epilepsy in rats, we tested the effects of serotonin depletion o
Autor:
Joana M. do Carmo, Pedro Andrade, Gisela H. Maia, José Paulo Andrade, Nikolai V. Lukoyanov, José L. Quesado, Joana I. Soares
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84722 (2014)
PLoS ONE
PLoS ONE
Treating rats with kainic acid induces status epilepticus (SE) and leads to the development of behavioral deficits and spontaneous recurrent seizures later in life. However, in a subset of rats, kainic acid treatment does not induce overt behaviorall