Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Joana Freitas-Silva"'
Autor:
Diana I. S. P. Resende, Fernando Durães, Sidika Zubarioglu, Joana Freitas-Silva, Nikoletta Szemerédi, Madalena Pinto, Eugénia Pinto, Paulo Martins da Costa, Gabriella Spengler, Emília Sousa
Publikováno v:
Pharmaceuticals, Vol 17, Iss 2, p 209 (2024)
Global health faces a significant issue with the rise of infectious diseases caused by bacteria, fungi, viruses, and parasites. The increasing number of multi-drug resistant microbial pathogens severely threatens public health worldwide. Antibiotic-r
Externí odkaz:
https://doaj.org/article/2c95e70dd07d42b88d028f4c8d9b3104
Autor:
Bruno Horta, Joana Freitas-Silva, Jani Silva, Francisca Dias, Ana Luísa Teixeira, Rui Medeiros, Honorina Cidade, Madalena Pinto, Fátima Cerqueira
Publikováno v:
Molecules, Vol 28, Iss 5, p 2159 (2023)
Chalcones are synthetic and naturally occurring compounds that have been widely investigated as anticancer agents. In this work, the effect of chalcones 1–18 against the metabolic viability of cervical (HeLa) and prostate (PC-3 and LNCaP) tumor cel
Externí odkaz:
https://doaj.org/article/9d36e3b9a8c34cdfbe0a017349941095
Autor:
Joana Cardoso, Joana Freitas-Silva, Fernando Durães, Madalena Pinto, Emília Sousa, Eugénia Pinto
Publikováno v:
Medical Sciences Forum, Vol 14, Iss 1, p 46 (2022)
Systemic fungal infections caused by filamentous fungi, particularly in the immunocompromised population, represent a serious threat to public health. The increase in resistant strains to classic antifungal drugs, especially azoles, is a global healt
Externí odkaz:
https://doaj.org/article/962acf9e557846f98245c959008e6d3c
Autor:
Ana Jesus, Fernando Durães, Nikoletta Szemerédi, Joana Freitas-Silva, Paulo Martins Costa, Eugénia Pinto, Madalena Pinto, Gabriella Spengler, Emília Sousa, Honorina Cidade
Publikováno v:
Medical Sciences Forum, Vol 14, Iss 1, p 68 (2022)
The effective response of antibiotics is threatened by the proliferation of micro-organisms that manifest resistance mechanisms, leading to an increase of progressively untreatable infectious diseases around the world. One solution to this problem co
Externí odkaz:
https://doaj.org/article/c38fd0246cff49ce9111f0278e2027a8
Autor:
Ana Rita Neves, Fernando Durães, Joana Freitas-Silva, Nikoletta Szemerédi, Paulo Martins-da-Costa, Eugénia Pinto, Marta Correia-da-Silva, Gabriella Spengler, Emília Sousa
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 14468 (2022)
The overexpression of efflux pumps is one of the strategies used by bacteria to resist antibiotics and could be targeted to circumvent the antibiotic crisis. In this work, a series of trimethoxybenzoic acid derivatives previously described as antifou
Externí odkaz:
https://doaj.org/article/a07751b8ba6b4554be3822b0d6c29718
Autor:
Joana Cardoso, Joana Freitas-Silva, Fernando Durães, Diogo Teixeira Carvalho, Luís Gales, Madalena Pinto, Emília Sousa, Eugénia Pinto
Publikováno v:
Antibiotics, Vol 11, Iss 11, p 1488 (2022)
Fungal infections are one of the main causes of mortality and morbidity worldwide and taking into account the increasing incidence of strains resistant to classical antifungal drugs, the development of new agents has become an urgent clinical need. C
Externí odkaz:
https://doaj.org/article/d40f753d48ef4ff7bdae45a45c72545b
Autor:
Ana Jesus, Fernando Durães, Nikoletta Szemerédi, Joana Freitas-Silva, Paulo Martins da Costa, Eugénia Pinto, Madalena Pinto, Gabriella Spengler, Emília Sousa, Honorina Cidade
Publikováno v:
Marine Drugs, Vol 20, Iss 5, p 315 (2022)
The growing number of infectious diseases around the world threatens the effective response of antibiotics, contributing to the increase in antibiotic resistance seen as a global health problem. Currently, one of the main challenges in antimicrobial
Externí odkaz:
https://doaj.org/article/0809e97d96c5425baabaeaf2136bcd34
Autor:
Fernando Durães, Sara Cravo, Joana Freitas-Silva, Nikoletta Szemerédi, Paulo Martins-da-Costa, Eugénia Pinto, Maria Elizabeth Tiritan, Gabriella Spengler, Carla Fernandes, Emília Sousa, Madalena Pinto
Publikováno v:
Pharmaceuticals, Vol 14, Iss 11, p 1141 (2021)
Antimicrobial peptides are one of the lines of defense produced by several hosts in response to bacterial infections. Inspired by them and recent discoveries of xanthones as bacterial efflux pump inhibitors, chiral amides with a xanthone scaffold wer
Externí odkaz:
https://doaj.org/article/a7abe5ef10784e8cbb60ef22a03b49a7
Autor:
Fernando Durães, Andreia Palmeira, Bárbara Cruz, Joana Freitas-Silva, Nikoletta Szemerédi, Luís Gales, Paulo Martins da Costa, Fernando Remião, Renata Silva, Madalena Pinto, Gabriella Spengler, Emília Sousa
Publikováno v:
Pharmaceuticals, Vol 14, Iss 6, p 572 (2021)
The overexpression of efflux pumps is one of the causes of multidrug resistance, which leads to the inefficacy of drugs. This plays a pivotal role in antimicrobial resistance, and the most notable pumps are the AcrAB-TolC system (AcrB belongs to the
Externí odkaz:
https://doaj.org/article/7e42754966b94444b1c0227c2486c774
Autor:
Rui Medeiros, Bruno Horta, Joana Freitas-Silva, Jani Silva, Francisca Dias, Emília Sousa, Madalena Pinto, Fátima Cerqueira
Publikováno v:
Molecules, Vol 26, Iss 12, p 3721 (2021)
Xanthone derivatives have shown promising antitumor properties, and 1-carbaldehyde-3,4-dimethoxyxanthone (1) has recently emerged as a potent tumor cell growth inhibitor. In this study, its effect was evaluated (MTT viability assay) against a new pan
Externí odkaz:
https://doaj.org/article/484279c09cab49debe3b78b8ac61a35c